TeachingSs07MISeminar

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

Hauptseminar: Molecular Imaging

by Tobias Lasser, Thomas Wendler and Prof. Dr. Nassir Navab

2 SWS, 4 ECTS

The seminar language is English.

Deadlines and dates fixed now - see Timeline

Participation

If you are interested in taking part in the seminar please

  • send an e-mail to .

Please include last and first name, matriculation number, current semester, discipline (diploma, master, bachelor) including major, and a desired topic.

April 30th, 2007 will be the last withdrawal date to withdraw your registration. Not withdrawing before this date will result in a 5.0 grade for unacceptable or incomplete work.

Abstract

The term molecular imaging can be broadly defined as the in vivo characterization and measurement of biologic processes at the cellular and molecular level. In contradistinction to "classical" diagnostic imaging, it sets forth to probe the molecular abnormalities that are the basis of disease rather than to image the end effects of these molecular alterations.
R. Weissleder, U. Mahmood: Molecular Imaging, Radiology 2001 219:316-333.

A new set of technologies, collectively termed "molecular imaging", is providing biologists with exciting new opportunities to study noninvasively and repetitively the mechanisms underlying normal development and disease in small-animal models. Using these imaging technologies, researchers can now measure, in living animals, dynamic biological processes such as metabolic activity, cell proliferation, apoptosis, receptor occupancy, reporter gene expression, and antigen modulation.
H. Herschman: Molecular Imaging: Looking at Problems, Seeing Solutions, Science 2003 302:605-608.

This seminar will allow its participants to gain insights into the field of molecular imaging. Topics will range from tracers, nuclear probes over micro-bubble US, PET/CT, MR Spectroscopy and Diffuse Optical Tomography to applications in pharmacokinetics, drug development and cancer diagnostics.

Schein requirements

As usual:
  • attendance of the Hauptseminar meeting
  • active class participation (discussions)
  • handout (8 - 16 pages) in LaTeX
  • presentation (approximately 60 minutes + discussion) in Powerpoint or PDF format

Timeline

You are required to meet the following deadlines for discussing your work with your supervisor:

  • 4-6 weeks before presentation: Outline
  • 2 weeks before presentation: Handout
  • 1 week before presentation: Presentation Slides

The deadlines for the documents have been fixed. The e-mail has to be sent to your supervisor.

  • Outline of work per mail up to Thursday 3.5. 23:59
  • Presentation slides per mail up to Thursday 24.5. 23:59
  • Report per mail up to Thursday 28.6. 23:59

Note: the presentations will take place during the week of the 11th of June (exact date and time to be decided between participants and supervisors, proposed Friday 16th from 13:00 to 17:00). Eventually depending on the weather a visit to a beer-garden after the presentations is planned.

Templates

Detailed Overview

Tracer kinetic modelling by nuclear imaging

  • Motivation (what is a tracer, what is kinetic modelling, why do we want to do it)
  • Tracer principle in the case of nuclear imaging (idea, tracers, labels, radiation types)
  • Kinetic models in living organisms (compartment model, input function, determination of the input function)
  • Examples with PET (pharmacokinetics, what we do at KRI)
  model.jpg

Intraoperative imaging nuclear probes

  • Intraoperative non-imaging probes (motivation, beta and gamma probes, detectors, limitations)
  • Imaging probes (idea, limitations, detectors, applications, examples)
  • New applications, new sensors
  nucmed1.jpg

Molecular imaging using US

  • Motivation (US vs. other molecular imaging modalities)
  • Principles of US (frequency, detector, emitter, image formation)
  • Micro bubbles (idea, limitations, applications, examples)
  us.jpg

MRI spectroscopy

  • Principles of MRI (spin, magnetization, T1, T2, T2*)
  • Spectroscopy (Chemical shift and molecular finger prints)
  • Parameter estimation (well-posed and ill-posed problems, how to use a priori information and dictionaries)
  • Example applications (prostate cancer, etc)
  MRS.jpg

Reconstruction for Computed Tomography

  • Principles of X-ray CT
  • Reconstruction Techniques (FBP, ART, SART)
  brain.jpg

Diffuse Optical Tomography

  • Principles of Optical Tomography (diffusion, image reconstruction)
  • Probes (targetting, activatable, fluorescent markers)
  • Principles of Fluorescence Molecular Tomography (FMT)
  • Example applications with FMT (in-vivo small animal imaging)
  maus.jpg

Non-contact FMT imaging

  • Motivation
  • Diffusion modeling with arbitrary boundaries (Born ratio, Kirchhoff approximation)
  • Surface reconstruction for boundary modeling
  • Example applications (nc FMT)
  surfmouse.jpg



TeachingForm
Title: Molecular Imaging
Professor: Prof. Dr. Nassir Navab
Tutors: Tobias Lasser, Thomas Wendler
Type: Hauptseminar
Information: 2 SWS, 4 ECTS
Term: 2007SoSe
Abstract: This seminar will allow its participants to gain insights into the field of molecular imaging. Topics will range from tracers, nuclear probes over micro-bubble US, PET/CT, MR Spectroscopy and Diffuse Optical Tomography to applications in pharmacokinetics, drug development and cancer diagnostics.


Edit | Attach | Refresh | Diffs | More | Revision r1.12 - 05 Jun 2007 - 11:01 - AndreasKeil

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