TeachingWs08MISeminar

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

Hauptseminar: Molecular Imaging

by Tobias Lasser, Thomas Wendler and Prof. Dr. Nassir Navab

2 SWS, 4 ECTS

The seminar language is English.

Participation

If you are interested in taking part in the seminar please

  • send an e-mail to .

Please include last and first name, matriculation number, current semester, discipline (diploma, master, bachelor) including major, and a desired topic.

October 10th, 2008 will be the last withdrawal date to withdraw your registration. Not withdrawing before this date will result in a 5.0 grade for unacceptable or incomplete work.

Abstract

A new set of technologies, collectively termed "molecular imaging", is providing biologists with exciting new opportunities to study noninvasively and repetitively the mechanisms underlying normal development and disease in small-animal models. Using these imaging technologies, researchers can now measure, in living animals, dynamic biological processes such as metabolic activity, cell proliferation, apoptosis, receptor occupancy, reporter gene expression, and antigen modulation.
H. Herschman: Molecular Imaging: Looking at Problems, Seeing Solutions, Science 2003 302:605-608.

This seminar will allow its participants to gain insights into the developments in the field of molecular imaging. Topics will focus on new imaging modalities, ranging from emerging optical imaging technologies towards more unconventional imaging modalities with applications in pharmacokinetics, drug development and cancer diagnostics. The methods presented in this seminar are applicable in medical imaging. Every student will prepare a talk on the basis of the selected topics (see table below). A short problem statement of the topic as well as the basic references will be provided.

Proposed topics

  • multi-spectral optical imaging devices
  • non-contact fluorescence molecular tomography
  • mesoscopic fluorescence tomography
  • photo-acoustic imaging
  • terahertz imaging
  • thermal imaging
  • molecular tracers for nuclear imaging

Motivation

Multispectral Optical Imaging Examples of multispectral images: images of a mouse with implanted tumors at different wavelengths. Images: institute for biological and medical imaging (ibmi), HelmholtzZentrum München
non-contact FMT Examples of non-contact FMT images: mouse with implanted fluorescence in FMT and X-ray CT. Images: Deliolanis et al, Opt. Lett. 32(4)
Mesoscopic Fluorescence Tomography Examples of mesoscopic FT images: in-vivo reconstruction of Drosophila salivary glands. Images: institute for biological and medical imaging (ibmi), HelmholtzZentrum München
Photo-acoustic Tomography Examples of photo-acoustic tomography images: hybrid photo-acoustic fluorescence molecular tomography images. Images: institute for biological and medical imaging (ibmi), HelmholtzZentrum München
thermal_imaging.jpg Example of thermal images: (a) arms, (b) legs and (c) feet of a healthy proband. Images: Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development
terahertz_imaging.jpg Example of terahertz images: (left) normal light image of a liver preparate, (right) terahertz image of the same, note the increased details, blue is tumor, red is healthy tissue. Images: Lehrstuhl für Photonik und Teraherzt-Technologie, Universität Bochum
nuclear_imaging.jpg Example of nuclear images: Serotonin receptors in brain. Using proper molecular tracers, functions and biodistributions alike can be images. Images: Forschungszentrum Jülich

Timeline

You are required to meet the following deadlines for discussing your work with your supervisor:

  • 4-6 weeks before presentation: Outline
  • 2 weeks before presentation: Handout
  • 1 week before presentation: Presentation Slides


Literature for Seminar

For each topic references from current literature will be provided.

Schein requirements

As usual:
  • attendance of the Hauptseminar meetings
  • active class participation (discussions)
  • handout (8 - 16 pages) in LaTeX
  • presentation (approximately 60 minutes incl. discussion) in Powerpoint or PDF format

Templates


TeachingForm
Title: Molecular Imaging
Professor: Nassir Navab
Tutors: Tobias Lasser, Thomas Wendler
Type: Hauptseminar
Information: 2 SWS, 4 ECTS
Term: 2008WiSe
Abstract: In this seminar we present different molecular imaging methods. We will focus on specific and interesting modalities and algorithms in this field.


Edit | Attach | Refresh | Diffs | More | Revision r1.9 - 10 Oct 2008 - 11:31 - TobiasLasser

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