phdDcomex

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

* Contact details: bjoern.menze@tum.de, ivan.ezhov@tum.de
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PhD position on the 'Inverse Biophysical Modeling and Machine Learning in Personalized Oncology' within EU Horizon2020 project

Description. Understanding the dynamics of brain tumor progression is essential for optimal treatment planning. Cast in a mathematical formulation, it can be viewed as an evaluation of a system of partial differential equations, wherein the underlying physiological processes that govern the growth of the tumor, such as diffusion and proliferation of tumor cells, are considered. To personalize the model, i.e. find a relevant set of parameters, with respect to the tumor dynamics of a particular patient, the model can be informed from empirical data, e.g., medical images obtained from different diagnostic modalities, such as magnetic-resonance imaging (MRI) or positron-emission tomography (PET).

We seek PhD? candidates to further develop computational approaches for solving the inverse problem in the context of brain tumor modeling with the aim to improve radiotherapy planning.

Keywords. Computational physiology, statistical inference, physics-informed deep learning

Prerequisites. Python/C++, ability to understand some math (probability theory, partial differential equations).

Related publications:
1. Menze, Bjoern H., et al. "A generative approach for image-based modeling of tumor growth." IPMI 2011.
2. Lipkova, Jana, et al. "Personalized radiotherapy Design for Glioblastoma: integrating mathematical tumor models, multimodal scans, and Bayesian inference." IEEE TMI 38.8 (2019): 1875-1884.
3. Ezhov, Ivan, et al. "Neural parameters estimation for brain tumor growth modeling." MICCAI 2019.


If interested, please send us (contact details above) your updated CV with references and transcripts.

  • Credit to Jana Lipkova:
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