Master's thesis: In vivo micro-CT imaging for the non-invasive assessment of tumor mouse models in preclinical anticancer drug research

Thesis by: Kristina Erhard
Advisor: Nassir Navab
Supervision by: Tobias Lasser, Thomas Pöschinger

Abstract

In this master’s thesis our focus is set on the implementation of advanced techniques in micro-CT imaging of lung, liver, and kidney cancer development and therapy. Micro-CT is a useful imaging modality for the assessment of anatomical and/or functional features of tumor growth in the whole animal and in a non-invasive manner. In specific, methods shall be implemented for the reduction of motion artifacts arising during imaging of a breathing living animal (respiratory-gated micro-CT imaging), and for the derivation of functional perfusion parameters during anti-angiogenic treatment of tumors (dynamic contrast-enhanced (DCE) micro-CT imaging).