Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

M. Feuerstein, H. Heibel, J. Gardiazabal, N. Navab, M. Groher
Reconstruction of 3-D Histology Images by Simultaneous Deformable Registration
Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2011), Toronto, Canada, September 2011.
The original publication is available online at

The reconstruction of histology sections into a 3-D volume receives increased attention due to its various applications in modern medical image analysis. To guarantee a geometrically coherent reconstruction, we propose a new way to register histological sections \emph{simultaneously} to previously acquired reference images and to neighboring slices in the stack. To this end, we formulate two potential functions and associate them to the same Markov random field through which we can efficiently find an optimal solution. Due to our simultaneous formulation and the absence of any segmentation step during the reconstruction we can dramatically reduce error propagation effects. This is illustrated by experiments on carefully created synthetic as well as real data sets.
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