Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

C. Ulas, PA. Gómez, JI. Sperl, C. Preibisch, MI. Menzel, A. Haase, B. Menze
A Robust Reconstruction Method for Quantitative Perfusion MRI: Application to Brain Dynamic Susceptibility Contrast (DSC) Imaging
Proceedings of the International Society of Magnetic Resonance in Medicine (ISMRM), Hawaii, USA, April 2017 (bib)

We propose a robust reconstruction model for dynamic perfusion magnetic resonance imaging (MRI) from undersampled k-space data. Our method is based on a joint penalization of the pixel-wise incoherence on temporal differences and patch-wise dissimilarities between spatio-temporal neighborhoods of perfusion image series. We evaluate our method on dynamic susceptibility contrast (DSC)-MRI brain perfusion datasets and demonstrate that the proposed reconstruction model can achieve up to 8-fold acceleration by yielding improved spatial reconstructions and providing highly accurate matching of perfusion time-intensity curves, thus leading to more precise quantification of clinically relevant perfusion parameters over two existing reconstruction methods.
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