Philipp Matthies

Dipl.-Phys. Univ. Philipp Matthies E-mail: Skype: Room 1: MI 03.13.058 Chair for Computer Aided Medical Procedures Technische Universität München Boltzmannstr. 3 85748 Garching b. München Germany Phone: +49 (89) 289-19401 (MI 03.13.058) Fax: +49 (89) 289-17059 Room 2: IFL (01.01.03a-c) Klinikum rechts der Isar Technische Universität München Ismaninger Str. 22 81675 München Germany Phone: +49 (89) 4140-6457 (IFL) Fax: +49 (89) 4140-6458 (IFL)

Research interests

• Intraoperative Radiation Therapy (ioRT)
  using low energy x-rays and advanced imaging and navigation
• Computer Aided Surgery / Image Guided Surgery
  Freehand SPECT
• Molecular Imaging
  SPECT, PET
• New Imaging Modalities
  3D intraoperative imaging using mini gamma cameras with semiconducting detectors
• Tracking
  Optical, electro-magnetic (EM)
• Modeling and Simulation
  Lookup tables for nuclear medicine detectors, Monte Carlo simulations using GATE

Student projects

• finished: Simulation-based Collimator Modeling and Optimization for Selective Internal Radiation Therapy (SIRT) by Milad Mesri (Bachelor thesis)
• finished: Count rate saturation effects in handheld gamma detectors – evaluation and influence on 3D intra-operative imaging (Master thesis/IDP)
• finished: Automation of Gamma Camera Calibrations by Beatrice Lentes (Software development project)
• finished: Development of a Matlab analyzation toolkit for 3D lookup tables by Shih Chen Hsuan (IDP)
• finished: Tracking and Visualization in ioRT by Ekaterina Mikaeva (Software development project)
• finished: Understanding and optimization of a low energy X-ray generator for intra-operative radiation therapy (Master thesis/IDP)
• finished: Integration of a gamma camera for 3D intra-operative functional imaging by Kanishka Sharma (Master thesis)
• finished: Radiation exposure and protection in radionuclide-guided surgery by Radu Diaconescu (IDP)
• finished: Evaluation of freehand SPECT image quality depending on different reconstruction parameters by Alexander Zhdanov (IDP)
• finished: Software and GUI for a gamma camera for intra-­operative functional imaging by Zijing Liu (Software development project)

Teaching

• Lecture Innovation Generation and Entrepreneurship in the Healthcare Domain (2016SoSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2016SoSe)
• Lecture Innovation Generation and Entrepreneurship in the Healthcare Domain (2015WiSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2015SoSe)
• Lecture Innovation Generation and Entrepreneurship in the Healthcare Domain (2014WiSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2014SoSe)
• Lecture Translational Technology Entrepreneurship (2014SoSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2013WiSe)
• Lecture Translational Technology Entrepreneurship (2013WiSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2013SoSe)
• Lecture Translational Technology Entrepreneurship (2013SoSe)
• Lecture Medical Technology Entrepreneurship (2012WiSe)
• Lecture Medical Technology Entrepreneurship (2012SoSe)
• Proseminar History of Computational Science, Vision, and Medical Science (2012SoSe)

Publications

2020
	A. K. Kogler, A. M. Polemi, S. Nair, S. Majewski, L. T. Dengel, C. L. Slingluff, B. Kross, S. J. Lee, J. E. McKisson?, J. McKisson?, A. G. Weisenberger, B. L. Welch, T. Wendler, P. Matthies, J. Traub, M. Witt, M. B. Williams Evaluation of camera-based freehand SPECT in preoperative sentinel lymph node mapping for melanoma patients EJNMMI Research 10. https://doi.org/10.1186/s13550-020-00729-8. (bib)
2019
	M. N. van Oosterom, P. Meershoek, , F. Pinto, P. Matthies, H. Simon, T. Wendler, N. Navab, C. J. H. van de Velde, H.G. van der Poel, F.W.B. van Leeuwen Extending the hybrid surgical guidance concept with freehand fluorescence tomography IEEE Trans Med Imaging;39(1):226-235. https://doi.org/10.1109/tmi.2019.2924254 (bib)
2018
	J. Neba, J. Wuestemann, P. Matthies, F. Pinto, A. Menzel, K. Schwenkenbecher, T. Barthel, O. S. Grosser, M. Lassmann Intraoperative molecular imaging investigation using a CZT detecor World Congress on Medical Physics and Biomedical Engineering, Prague, Czech Republic, June 2018 (bib)
	P. Matthies, J. Wuestemann, J. Neba, F. Pinto, O. S. Grosser First validation of semi-automatic liver segmentation algorithm World Congress on Medical Physics and Biomedical Engineering, Prague, Czech Republic, June 2018 (bib)
2017
	J. Wuestemann, F. Pinto, M. Mesri, P. Matthies, J. Neba, M. Pech, M. J. Tapner, M. C. Kreissl, M. Lassmann, O. S. Grosser Interventional Real-Time Quantification of 90Y-Microspheres Distribution in Selective Internal Radiotherapy European Association of Nuclear Medicine (EANM) Congress, Vienna, Austria, October 2017 (bib)
	P. Matthies, M. Mesri, F. Pinto, J. Wuestemann, O. S. Grosser Patient specific scatter reduction in SIRT gamma camera images International Conference on Monte Carlo Techniques for Medical Applications, Naples, Italy, October 2017 (bib)
2016
	J. Gardiazabal, P. Matthies, J. Vogel, B. Frisch, N. Navab, S. I. Ziegler, T. Lasser Flexible Mini Gamma Camera Reconstructions of Extended Sources using Step and Shoot and List Mode Medical Physics 43(12):6418-6428, 2016. (bib)
	C. Bluemel, P. Matthies, K. Herrmann, S. P. Povoski 3D Scintigraphic Imaging and Navigation in Radioguided Surgery: Freehand SPECT Technology and its Clinical Applications Expert Review of Medical Devices, 2016 (bib)
2015
	P. Matthies, B. Frisch, J. Vogel, T. Lasser, M. Friebe, N. Navab Inside-Out Tracking for Flexible Hand-held Nuclear Tomographic Imaging IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
	J. Gardiazabal, B. Frisch, P. Matthies, J. Vogel, S. I. Ziegler, N. Navab, T. Lasser List-Mode Reconstruction for Continuous Freehand SPECT Acquisitions IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
	J. Gardiazabal, J. Vogel, P. Matthies, M. Wieczorek, B. Frisch, N. Navab, S. I. Ziegler, T. Lasser Fully 3D thyroid imaging with mini gamma cameras Proceedings of Fully3D, Newport, USA, June 2015 (bib)
	T. Lasser, J. Gardiazabal, M. Wieczorek, P. Matthies, J. Vogel, B. Frisch, N. Navab Towards 3D thyroid imaging using robotic mini gamma cameras Bildverarbeitung für die Medizin, Lübeck, Germany, March 2015 (bib)
2014
	B. Frisch, M. Eiber, J. Gardiazabal, P. Matthies, T. Maurer, A. Okur, T. Lasser, N. Navab Challenges for Intra-Operative SPECT IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
	J. Gardiazabal, M. Esposito, P. Matthies, A. Okur, J. Vogel, S. Kraft, B. Frisch, T. Lasser, N. Navab Towards personalized interventional SPECT-CT imaging Proceedings of the 17th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Boston, USA, September 2014 (bib)
	P. Matthies, J. Gardiazabal, A. Okur, T. Lasser, N. Navab Accuracy evaluation of interventional nuclear tomographic reconstruction using mini gamma cameras The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib)
	P. Matthies, J. Gardiazabal, A. Okur, J. Vogel, T. Lasser, N. Navab Mini Gamma Cameras for Intra-operative Nuclear Tomographic Reconstruction Medical Image Analysis 18(8):1329-1336, 2014 (bib)
	M. Friebe, A. Katouzian, P. Matthies, S. O. Cho Miniaturized cold emission low energy X-ray tubes for MRI guided intraoperative radiation therapy - A technical feasibility study Poster presentation and book of abstracts, IGIC 2014, Magdeburg (bib)
	M. Friebe, H.-W. Henke, P. Matthies, A. Katouzian, G. Krombach MRI biopsy with semi-automated biopsy needle in Slicer 3D environment Poster presentation and book of abstracts, IGIC 2014, Magdeburg (bib)
	M. Friebe, P. Matthies, S. O. Cho Low Energy Radiation Therapy - feasibility of using a field emission miniature X-ray tube for intraoperative treatments under MRI guidance Oral presentation and book of abstracts, CARS 2014 annual meeting, Fukuoka (bib)
2013
	P. Matthies, K. Sharma, A. Okur, J. Gardiazabal, J. Vogel, T. Lasser, N. Navab First use of mini gamma cameras for intra-operative robotic SPECT reconstruction Proceedings of the 16th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nagoya, Japan, September 2013 (bib)
	P. Matthies, S. O. Cho, M. Friebe Integration of a low energy radiation source in MRI environment for intraoperative applications - a Feasibility Evaluation 25th International Conference of the International Society for Medical Innovation and Technology, iSMIT 2013 in Baden-Baden, Germany, September 05-07, 2013 (bib)
	P. Matthies, A. Okur, T. Wendler, N. Navab, M. Friebe Combination of intra-operative freehand SPECT imaging with MR images for guidance and navigation IEEE Engineering in Medicine and Biology (EMBC), Osaka, Japan, July 2013. (bib)
	A. Okur, D. I. Shakir, P. Matthies, A. Hartl, M. Essler, S. I. Ziegler, T. Lasser, N. Navab Freehand Tomographic Nuclear Imaging Using Tracked High-Energy Gamma Probes Bildverarbeitung für die Medizin 2013 (BVM), Heidelberg, Germany, March 2013. The original publication is available online at www.springerlink.com (bib)
2012
	D. I. Shakir, A. Okur, A. Hartl, P. Matthies, M. Essler, S. I. Ziegler, T. Lasser, N. Navab Towards Intra-operative PET for Head and Neck Cancer: Lymph Node Localization Using High-energy Probes Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nice, France, October 2012 (bib)

Short CV

• 12/2011 - present:
  Technische Universität München - Munich, Germany
  Ph.D. Student at the Chair for Computer Aided Medical Procedures & Augmented Reality.
  Research funded by CAMP and SFB 824 Project A2 (Navigierte intra-operative nuklearmedizinische Bildgebungssonden)

• 10/2005 - 07/2011:
  Technische Universität München - Munich, Germany
  Studies in Physics
  Graduated as Diplom-Physiker Univ. (equivalent to a M.Sc. in Physics), with distinction.
  Diplomarbeit (DA): Design and optimization of an intraoperative mini gamma camera for the use with Freehand SPECT
  

• 1996 - 2005
  Gymnasium am Mosbacher Berg - Wiesbaden, Germany

Research projects

Freehand SPECT for Sentinel Lymph Node Localization In medical collaboration with: Prof. Dr. Markus Schwaiger, Chefarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany PD Dr. Andreas Buck, Oberarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Ken Herrmann, Assistenzarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany Prof. Dr. Marion Kiechle, Chefarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Stefan Paepke, Leitender Oberarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Andreas Schnelzer, Oberarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Alexandra Ehlerding, Assistenzarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Prof. Dr. Helmuth Friess, Chefarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Marc Martignoni, Oberarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Jakob Saeckl, Assistenzarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany Prof. Dr. Stefano Fanti, Chefarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy Dr. Ivan Santi, Assistenzarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy Dr. Lorenzo Fantini, Assistenzarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy Scientific Director: Nassir Navab, Sibylle Ziegler Contact Person(s): TobiasLasser, Asli Okur; Philipp Matthies In industrial collaboration with: Dr. Joerg Traub, CEO, SurgicEye GmbH, Munich, Germany Dr. Thomas Wendler, CTO, SurgicEye GmbH, Munich, Germany

Intra-operative Imaging and Navigation for Minimal Invasiveness in Head and Neck Cancer In medical collaboration with: Prof. Dr. Markus Essler, Nuclear Medicine Dept., Klinikum rechts der Isar, TUM, Munich, Germany Scientific Director: Nassir Navab, Sibylle Ziegler Contact Person(s): Dzhoshkun Ismail Shakir

Going to work by bike

In about 40min from München Bogenhausen to Campus Garching. Only 1km street and then 15km Isar-Radweg.
Check out the GPS-Track I recorded here.

Coffee Consumption Histogram

6 3 7 6 8 4 7 5 4 6 1 1 7 8 9 10 11 12 13 14 15 16 17 19 Philipp Matthies Coffee Consumption Table