IVUSSimulation

Intravascular Ultrasound Simulation from Histology In medical collaboration with: Department of Radiology - Klinikum Rechts der Isar Scientific Director: Prof. Dr. Nassir Navab Contact Person(s): Silvan Kraft

Keywords: Medical Imaging, Ultrasound, IFL

Abstract

We introduce a framework to simulate intravascular ultrasound (IVUS) from histological sections. These sections were previously acquired along with real IVUS radiofrequency signals using single-element 40MHz transducer. After labeling and registering the section to the corresponding IVUS image, a virtual phantom was created, incorporating nuclei scatterer patterns. A finite differences simulation of the acoustic signal was performed, resulting in backscattered radiofrequency signals. These were used to process a B-mode image, which in turn was compared to the real IVUS image of the same section. A high image quality with a very promising correlation to the original IVUS images was achieved.

Pictures

Figure 1: Numeric framework for simulating the propagation of ultrasound through tissue

Figure 2: Comparison of the real intravascular Ultrasound B-mode image to a simulated image

Clinical Relevance

Over 8 millions people die from strokes or cardiac diseases each year. Over half of these are caused by atherosclerosis. Intravascular Ultrasound (IVUS) is an excellent tool for diagnosing atherosclerosis, as stenosis and calcified tissues are clearly visible. However critical structures as vulnerable plaques are hard to identify with conventional means. Simulating IVUS and developing acoustic models for relevant tissue types will help in a better understanding of the physical processes within tissues and their interaction with acoustic waves. These will eventually lead to improved tissue characterization methods.

Team

Contact Person(s)

Dipl.-Ing. Univ. Silvan Kraft

Working Group

Dr. Amin Katouzian

Dr. Athanasios Karamalis

Dr. Christoph Hennersperger

Debdoot Sheet

Dr. Peter Noel

Location

Technische Universität München Institut für Informatik / I16 Boltzmannstr. 3 85748 Garching bei München Tel.: +49 89 289-17058 Fax: +49 89 289-17059

Visit our lab at Garching.

Klinikum rechts der Isar der Technischen Universitüt München Ismaninger Str. 22 81675 München IFL Lab - Room: 01.3a-c Tel.: +49 89 4140-6457 Fax: +49 89 4140-6458

Visit our lab at Klinikum rechts der Isar.



internal project page

Please contact Silvan Kraft for available student projects within this research project.