|M. Paschali, F. Naeem, W. Simson, K. Steiger, M. Mollenhauer, N. Navab
Deep Learning Under the Microscope: Improving the Interpretability of Medical Imaging Neural Networks
The first two authors contributed equally.
The original manuscript is available currently online on arXiv. (bib)
|In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch and trained with weak supervision for WSI classification. MIL avoids label ambiguity and enhances our model's expressive power without guiding its attention. We utilize a fine-grained logit heatmap of the models activations to interpret its decision-making process. The proposed method is quantitatively and qualitatively evaluated on two challenging histology datasets, outperforming a variety of baselines. In addition, two expert pathologists were consulted regarding the interpretability provided by our method and acknowledged its potential for integration into several clinical applications.
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