C. Özgür, J. Bieniarz, T. Lasser, S. I. Ziegler, N. Navab, T. Wendler Phenomenological Models for intraoperative Positron Emission Surface Imaging using Handheld Probes Proceedings of World Congress in Medical Physics and Biomedical Engineering (WC 2009), Munich, Germany, September 2009 (bib)
	One of the major issues in cancer resection is to guarantee that the complete tumor is included within the extracted tissue. Today beyond the eye of the surgeon, the only intraoperative confirmatory technique is the use of frozen sections. Novel methods [1] have suggested lately the use of positron-emitting radiotracers for controlling resection borders by imaging the radiotracer distribution on the tumor bed. If successful, this method can provide information complementary to frozen sections, such as a better spatial resolution and the possibility of evaluating the borders iteratively. Furthermore, in some cases where frozen section biopsy is not standardized for specific tissues (like in bonny structures [2]), surface radio-activity imaging can be a break-through. Generating 3D surface images of the positron emission dis-tribution requires however proper models of the detection process if meant to be done using one dimensional handheld probes. In this paper, we introduce phenomelogical models for posi-tron detection using handheld beta probes as logical extensions of the methods proposed in [1]. These models were implemented, their parameters determined and validated experi-mentally. By introducing more a priori information in this yet experimental imaging modality we strongly believe that its quality can be boosted and thus it can be brought closer to application towards a securer cancer resection. (references: [1] Wendler T, Traub J, Ziegler S, Navab N (2006) Navigated three dimensional beta probe for optimal cancer resection, LNCS Proc. Vol. 4190, Medical Image Computing and Computer Assisted Intervention Society, Copenhagen, Denmark, 2006, pp 561–569 [2] Bui MM, Smith P, Agresta SV, Cheong D, Letson GD (2008) Practi-cal Issues of Intraoperative Frozen Section Diagnosis of Bone and Soft Tissue Lesions. Cancer Control 15(1):7–12.)
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