Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

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N. Deliolanis, T. Lasser, D. Hyde, A. Soubret, J. Ripoll, V. Ntziachristos
Free-space fluorescence molecular tomography utilizing 360° geometry projections
Optics Letters 32(4):382-384, January 2007 (bib)

Fluorescence tomography of diffuse media can yield optimal three-dimensional imaging when multiple projections over 360° geometries are captured, compared with limited projection angle systems such as implementations in the slab geometry. We demonstrate how it is possible to perform noncontact, 360° projection fluorescence tomography of mice using CCD-camera-based detection in free space, i.e., in the absence of matching fluids. This approach achieves high spatial sampling of photons propagating through tissue and yields a superior information content data set compared with fiber-based 360° implementations. Reconstruction feasibility using 36 projections in 10° steps is demonstrated in mice.
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