Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

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B. Frisch, et al.
First Results with an Interventional Handheld PET
IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)

Radioguided surgery has proven to be a valuable tool for the interventional localisation of radioactive hotspots, guiding the physician to target tissue sampling for a biopsy or to identify cancerous tissue for resection. It is however mostly restricted to the use of low-energy gamma-emitting radiotracers. Indeed, while Positron Emission Tomography (PET) is an established functional imaging method for cancer diagnosis and staging, it is limited by its most common design in a gantry-based setup as well as the long time to acquire sufficient data to reconstruct an image, preventing its use as an intra-operative device. We develop a system which, composed of an external detector plate held by a mechanic arm and a handheld light-weight detector coupled to an ultrasound transducer, would allow for the live acquisition of multimodal PET/US images in an interventional environment. The detectors are based on matrices of 4x4 LYSO:Ce crystals coupled to arrays of 4x4 SiPMs?. In the plate, 256 matrices are grouped by 4 and read out by 64-channel ASICs, of which 16 are hosted by each front-end board. The endoscope consists in 2 matrices read out in a similar way. A PCIe data acquisition card concentrates event data for coincidence sorting. The position of both detectors is recorded with an optical tracking system. An iterative ML-EM algorithm reconstructs the image. We present energy spectra and reconstructed images acquired on a phantom where four cylindrical sources filled with FDG can be clearly identified.
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