ProjectGammaProbe

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

Freehand SPECT for Sentinel Lymph Node Localization

Freehand SPECT for Sentinel Lymph Node Localization

In medical collaboration with:
Prof. Dr. Markus Schwaiger, Chefarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany
PD Dr. Andreas Buck, Oberarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany
Dr. Ken Herrmann, Assistenzarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany
Prof. Dr. Marion Kiechle, Chefarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany
Dr. Stefan Paepke, Leitender Oberarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany
Dr. Andreas Schnelzer, Oberarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany
Dr. Alexandra Ehlerding, Assistenzarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany
Prof. Dr. Helmuth Friess, Chefarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany
Dr. Marc Martignoni, Oberarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany
Dr. Jakob Saeckl, Assistenzarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany
Prof. Dr. Stefano Fanti, Chefarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy
Dr. Ivan Santi, Assistenzarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy
Dr. Lorenzo Fantini, Assistenzarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy

Scientific Director: Nassir Navab, Sibylle Ziegler

Contact Person(s): TobiasLasser, Asli Okur; Philipp Matthies

In industrial collaboration with:
Dr. Joerg Traub, CEO, SurgicEye GmbH, Munich, Germany
Dr. Thomas Wendler, CTO, SurgicEye GmbH, Munich, Germany

Keywords: Medical Imaging, Molecular Imaging, Computer-Aided Surgery, Medical Augmented Reality, IFL

Abstract

Nuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging.

Publications

2016
C. Bluemel, P. Matthies, K. Herrmann, S. P. Povoski
3D Scintigraphic Imaging and Navigation in Radioguided Surgery: Freehand SPECT Technology and its Clinical Applications
Expert Review of Medical Devices, 2016 (bib)
2015
T. Lasser, J. Gardiazabal, M. Wieczorek, P. Matthies, J. Vogel, B. Frisch, N. Navab
Towards 3D thyroid imaging using robotic mini gamma cameras
Bildverarbeitung für die Medizin, Lübeck, Germany, March 2015 (bib)
C. Vetter, T. Lasser, A. Okur, N. Navab
1D-3D Registration for Intra-operative Nuclear Imaging in Radio-guided Surgery
IEEE Transactions on Medical Imaging 34(2):608-617, 2015 (bib)
A. Hartl, D. I. Shakir, T. Lasser, S. I. Ziegler, N. Navab
Detection models for freehand SPECT reconstruction
Physics in Medicine and Biology 60(3):1031-1046, 2015 (bib)
2014
A. Okur, C. Hennersperger, J.B. Runyan, J. Gardiazabal, M. Keicher, S. Paepke, T. Wendler, N. Navab
fhSPECT-US Guided Needle Biopsy of Sentinel Lymph Nodes in the Axilla: Is it Feasible?
Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, Lecture Notes in Computer Science Volume 8673, 2014, pp 577-584 (bib)
I. Einspieler, A.R. Novotny, A. Okur, M. Essler, M. E. Martignoni
First Experience With Image-guided Resection of Paraganglioma
Clinical Nuclear Medicine, Volume 39, Issue:8, August 2014. (bib)
A. Okur, R. Voigt, R. Stauder, N. Navab
Investigation of performance log files of freehand SPECT acquisitions for usage characteristics and surgical phase determination
The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib)
P. Matthies, J. Gardiazabal, A. Okur, J. Vogel, T. Lasser, N. Navab
Mini Gamma Cameras for Intra-operative Nuclear Tomographic Reconstruction
Medical Image Analysis 18(8):1329-1336, 2014 (bib)
A. Okur, C. Gerngross, A. Schnelzer, A. Ehlerding, M. Keicher, S. Wiesner, S. Paepke, K. Scheidhauer, T. Wendler
First experience with fused ultrasound / freehand SPECT system for hybrid lymphatic mapping in breast cancer patients
52. Jahrestagung der Deutschen Gesellschaft fuer Nuklearmedizin, Hannover, Germany, Mar. 26 - 29, 2014. (bib)
A.L. Mihaljevic, A. Rieger, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring innovative freehand SPECT to the operating room: First experiences with sentinel lymph node biopsy in malignant melanoma
European Journal of Surgical Oncology (EJSO), Volume 40, Issue 1, January 2014. (bib)
2013
J. Gardiazabal, T. Reichl, A. Okur, T. Lasser, N. Navab
First flexible robotic intra-operative nuclear imaging for image-guided surgery
Information Processing in Computer Assisted Interventions (IPCAI), Heidelberg, Germany, June 26, 2013 (bib)
C. Bluemel, A. Schnelzer, A. Okur, A. Ehlerding, S. Paepke, K. Scheidhauer, M. Kiechle
Freehand SPECT for image-guided sentinel lymph node biopsy in breast cancer
European Journal of Nuclear Medicine and Molecular Imaging.
The original publication is available online at www.springerlink.com
(bib)
J. Vogel, T. Lasser, J. Gardiazabal, N. Navab
Trajectory optimization for intra-operative nuclear tomographic imaging
Medical Image Analysis 17(7):723-731, 2013. (bib)
2012
A. Schnelzer, A. Ehlerding, C. Bluemel, A. Okur, K. Scheidhauer, S. Paepke, M. Kiechle
Showcase of Intraoperative 3D Imaging of the Sentinel Lymph Node in a Breast Cancer Patient using the New Freehand SPECT Technology
Breast Care 2012;7:484-486 (bib)
J. Vogel, T. Reichl, J. Gardiazabal, N. Navab, T. Lasser
Optimization of Acquisition Geometry for Intra-operative Tomographic Imaging
Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nice, France, October 2012 (bib)
I. Einspieler, A. Okur, A.R. Novotny, M. E. Martignoni, K. Scheidhauer
Case Report - Image-guided Resection of Paraganglioma
32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib)
A. Rieger, J. Saeckl, R. Hein, A. Okur, T. Wendler, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring Innovative Freehand SPECT to the Operating Room - First Experiences with Sentinel Lymphonodectomy in Malignant Melanoma
32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib)
N. Navab, T. Blum, L. Wang, A. Okur, T. Wendler
First Deployments of Augmented Reality in Operating Rooms
IEEE Computer, Volume 45, Issue 7, pp. 48-55 (bib)
C. Bluemel, A. Schnelzer, A. Rieger, A. Ehlerding, A. Okur, C. Gerngross, M. E. Martignoni, K. Scheidhauer, M. Schwaiger
3D navigated (radio-guided) sentinel lymph node biopsy using freehand SPECT : final evaluation of Munich's pilot experience in the operating room
50. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Messe Bremen, Germany, April 2012 (bib)
A. Hartl, D. I. Shakir, R. Kojchev, N. Navab, S. I. Ziegler, T. Lasser
Freehand SPECT reconstructions using look up tables
SPIE Medical Imaging Conference, February 4 - February 9 2012, San Diego, USA (bib)
2011
C. Vetter, T. Lasser, T. Wendler, N. Navab
1D-3D Registration for Functional Nuclear Imaging
Medical Image Computing and Computer Assisted Intervention (MICCAI), Toronto, Canada, September 20-24 2011. (bib)
A. Okur, A. Ahmadi, A. Bigdelou, T. Wendler, N. Navab
MR in OR: First analysis of AR/VR visualization in 100 intra-operative Freehand SPECT acquisitions
The 10th IEEE and ACM International Symposium on Mixed and Augmented Reality (ISMAR), Basel, Switzerland, Oct. 26 - 29, 2011. (bib)
A. Hartl, T. Lasser, N. Navab, S. I. Ziegler
Impact of acquisition geometry and physical model on Freehand SPECT reconstructions
IEEE Medical Imaging Conference, October 23 - October 29 2011, Valencia, Spain (bib)
C. Bluemel, A. Schnelzer, A. Ehlerding, A. Okur, K. Scheidhauer, M. Kiechle, M. Schwaiger
Evaluation of freehand SPECT in sentinel lymph node biopsy of breast cancer
Proceedings of the Annual Congress of the European Association of Nuclear Medicine (EANM), Birmingham, UK, October 2011 (bib)
A. Rieger, J. Saeckl, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Wendler, J. Traub, H. Friess, M. E. Martignoni
First Experiences with Navigated Radio-Guided Surgery Using Freehand SPECT
Case Reports in Oncology, August 2011 (bib)
A. Okur, C. Bluemel, A. Ehlerding, K. Scheidhauer, A. Schnelzer
Meme kanseri cerrahisinde freehandSPECT ile ilk tecrube: Aksiller sentinel lenf nodu biyopsisinde uc boyutlu navigasyon ve kalite guvencesi
XI. Ulusal Meme Hastaliklari Kongresi, Antalya, Turkey, Oct. 5 - 9, 2011. (bib)
C. Lapa, J. Saeckl, A. Rieger, C. Bluemel, A. Okur, T. Wendler, M. E. Martignoni, K. Scheidhauer
Investigating added value of freehand SPECT in sentinel node biopsy of melanomas
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib)
C. Bluemel, A. Ehlerding, C. Lapa, A. Okur, T. Wendler, A. Schnelzer, K. Scheidhauer
Improvements in sentinel node biopsy of breast cancer using freehand SPECT
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib)
2010
T. Wendler, T. Lasser, S. I. Ziegler, K. Scheidhauer
Freehand SPECT/US: new approach for intraoperative hybrid imaging of sentinel nodes
Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib)
T. Wendler, D. Zaeuner, S. Wiesner, K. Scheidhauer
Fused SPECT/CT and real-time video visualization for intraoperative guidance in SLNB of head and neck malignancies
Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib)
K. Scheidhauer, A. Ehlerding, J. Saeckl, A. Rieger, K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Wendler
Feasibility evaluation of freehand SPECT for intraoperative 3D lymphatic mapping
Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib)
I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, S. Nicolini, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT 3D-imaging for sentinel lymph node mapping in breast cancer: preliminary preoperative study for future intraoperative use in the operating room
Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib)
M. C. Kreissl, T. Wendler, K. Herrmann, K. Scheidhauer
Freehand SPECT: First experiences with a new method of 3D-SLN mapping in melanoma
Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib)
I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT for sentinel lymph node biopsy: first clinical experience
Proceedings of EANM 2010, Vienna, Austria, October 2010 (bib)
A. K. Buck, A. Ehlerding, J. Saeckl, K. Herrmann, T. Wendler, M. E. Martignoni, A. Schnelzer, M. Schwaiger
Evaluation of feasibility of freehand SPECT in the operating room
Proceedings of EANM 2010, Vienna, Austria, October 2010 (bib)
A. Schnelzer, A. Ehlerding, T. Chen, T. Wendler, K. Scheidhauer, S. Paepke, M. Kiechle
Sentinel lymph node detection with intraoperative freehand SPECT in breast cancer patients
Proceedings of the Annual Meeting of the German Society of Gynecology and Obstetrics (DGGG) 2010, Munich, Germany, October 2010 (bib)
A. Ehlerding, A. Schnelzer, T. Wendler, K. Herrmann, T. Lasser, K. Scheidhauer, O. Kutter, T. Schuster, M. Schwaiger, A. K. Buck, S. I. Ziegler, N. Navab, S. Paepke, M. Kiechle
Vorstellung der Pilotstudie zur 3D-Darstellung des Wächterlymphknotens bei Brustkrebspatientinnen mittels Freehand-SPECT
Proceedings of Annual Meeting of the German Society of Senology (DGS), Hamburg, Germany, Jul. 2010 (bib)
T. Wendler, K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Lasser, J. Traub, A. Ehlerding, J. Saeckl, N. Navab, M. Kiechle, H. Friess, M. Schwaiger, S. I. Ziegler, A. K. Buck
Visione 3-D SPECT intraoperatoria: una nuova metodica per chirurgia radioguiata
Proceedings of SICO 2010, Milan, Italy, June 2010 (bib)
I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT for sentinel lymph node biopsy: first clinical experience
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib)
M. C. Kreissl, A. Okur, T. Chen, A. Bartel, T. Wendler, K. Scheidhauer
Pilot study of freehand SPECT for lymphatic mapping in melanoma in upper body
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib)
K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Wendler, A. K. Buck
Evaluation of feasibility of freehand SPECT in the operating room
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib)
T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, A. Ehlerding, K. Scheidhauer, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First Demonstration of 3D Lymphatic Mapping using freehand SPECT
Proceedings of the International Conference on Sentinel Node Biopsy and Radioguided Head & Neck Surgery (SNB), Copenhagen, Denmark, May 2010 (bib)
J. Saeckl, A. Ehlerding, K. Herrmann, T. Wendler, M. Schwaiger, M. Kiechle, H. Friess, A. K. Buck, A. Schnelzer, M. E. Martignoni
Evaluation of feasibility of freehand SPECT in the operating room
Proceedings of the International Conference on Sentinel Node Biopsy and Radioguided Head & Neck Surgery (SNB), Copenhagen, Denmark, May 2010 (bib)
A. K. Buck, A. Schnelzer, T. Wendler, K. Herrmann, T. Lasser, J. Traub, O. Kutter, T. Schuster, A. Ehlerding, K. Scheidhauer, M. Kiechle, N. Navab, S. I. Ziegler, M. Schwaiger
First demonstration of 3D lymphatic mapping in breast cancer using freehand SPECT
Proceedings of DGN Nuklearmedizin 2010, Leipzig, Germany, April 2010 (bib)
K. Herrmann, A. Schnelzer, T. Wendler, M. Hoyer, D. Weisgerber, T. Lasser, S. Paepke, M. E. Martignoni, M. Kiechle, N. Navab, S. I. Ziegler, M. Schwaiger
Evaluation of feasibility of freehand SPECT in the operating room
Proceedings of DGN Nuklearmedizin 2010, Leipzig, Germany, April 2010 (bib)
T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, A. Ehlerding, K. Scheidhauer, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First demonstration of 3-D lymphatic mapping in breast cancer using freehand SPECT
European Journal of Nuclear Medicine and Molecular Imaging, Springer Berlin/Heidelberg, 2010 Aug;37(8):1452-61. Epub 2010 Mar 31. (bib)
2009
J. Traub, K. Herrmann, T. Lasser, N. Navab, S. I. Ziegler, A. K. Buck, T. Wendler
Freehand SPECT/Ultrasound Fusion for Hybrid Image-guided Resection
Proceedings of RSNA 2009, Chicago, USA, December 2009 (bib)
T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
Clinical introduction of freehand SPECT for image-guided sentinel lymph node biopsy
Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib)
T. Wendler, X. Feng, K. Herrmann, T. Lasser, J. Traub, S. I. Ziegler, N. Navab, A. K. Buck
2D/3D registration of freehand SPECT and planar scintigraphy for clinical evaluation of 3D thyroid scintigraphy
Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib)
T. Wendler, K. Herrmann, T. Lasser, J. Traub, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First experience with freehand SPECT for lymphatic mapping in melanoma in upper body
Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib)
T. Wendler, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
Freehand SPECT / ultrasound fusion for hybrid image-guided resection
Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib)
T. Lasser, A. Duliu, T. Wendler, S. I. Ziegler, N. Navab
Interactive Reconstruction for Freehand SPECT: An Approach to Acquisition Guidance?
Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib)
X. Feng, K. Szajkowska, T. Lasser, S. I. Ziegler, N. Navab, T. Wendler
2D/3D registration of freehand SPECT and planar scintigraphy for clinical evaluation of 3D thyroid scintigraphy
Proceedings of World Congress in Medical Physics and Biomedical Engineering (WC 2009), Munich, Germany, September 2009 (bib)
J. Traub, K. Herrmann, T. Wendler, T. Lasser, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First clinical results of freehand SPECT for lymphatic mapping in breast cancer
Proceedings of the Molekulare Bildgebung (MOBI), Berlin, Germany, Jun. 2009 (bib)
T. Wendler, K. Herrmann, T. Lasser, J. Traub, M. Schwaiger, S. I. Ziegler, N. Navab, A. K. Buck
Freehand SPECT: first in-vivo evaluation and comparison to conventional lymphatic mapping
Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2009), Toronto, Canada, June 2009 (bib)
T. Wendler, X. Feng, T. Lasser, K. Herrmann, J. Traub, K. Scheidhauer, S. I. Ziegler, D. Lenhart, J. Grahneis, M. Schwaiger, N. Navab, A. K. Buck
Freehand SPECT for 3D thyroid scintigraphy: first patient report
Proceedings of DGN Nuklearmedizin 2009, Leipzig, Germany, April 2009 (bib)
K. Herrmann, T. Wendler, T. Chen, A. Bartel, T. Lasser, K. Scheidhauer, J. Traub, T. Schuster, S. I. Ziegler, M. Schwaiger, A. K. Buck, N. Navab
Freehand SPECT: first in-vivo use for lymphatic mapping and comparison to conventional imaging
Proceedings of DGN Nuklearmedizin 2009, Leipzig, Germany, April 2009 (bib)
2008
T. Wendler, T. Lasser, A. K. Buck, C. Özgür, M. Schwaiger, S. I. Ziegler, N. Navab
First in Vivo Use of a Fused Gamma Ultrasound System
Proceedings of RSNA 2008, Chicago, USA, December 2008 (bib)
T. Wendler, T. Lasser, S. I. Ziegler, N. Navab
Towards Confident 3D Tomographic Reconstruction for Asymmetric, Sparse Detector Geometries
Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib)
T. Lasser, T. Wendler, S. I. Ziegler, N. Navab
Towards Reproducibility of Freehand 3D Tomographic Nuclear Imaging
Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib)
T. Lasser, T. Wendler, J. Traub, S. I. Ziegler, N. Navab
Definition of optimal collimator geometries for 3D tomographic thyroid scintigraphy using navigated gamma probes
Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008 (bib)
T. Wendler, T. Lasser, A. K. Buck, J. Traub, M. Schwaiger, S. I. Ziegler, N. Navab
First case report of 3D tomographic thyroid scintigraphy with tracked gamma probes
Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008, Eur J Nuc Med Mol Imaging, vol. 35 (Suppl. 2), S129 (bib)
T. Wendler, J. Traub, T. Lasser, M. Feuerstein, J. Vogel, S. I. Ziegler, N. Navab
Combined ultrasound and gamma probe imaging for examination of thyroid nodules
Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib)
T. Wendler, A. Hartl, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
3D Intra-operative nuclear imaging for SLNB in neck
Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib)
N. Navab, J. Traub, A. K. Buck, S. I. Ziegler, T. Wendler
Navigated nuclear probes for intra-operative functional imaging
Proceedings of 5th IEEE International Symposium on Biomedical Imaging (ISBI 2008), Paris, France, May 14 - 17 2008, pp. 1395-1398 (bib)
2007
T. Wendler, M. Feuerstein, J. Traub, T. Lasser, J. Vogel, F. Daghighian, S. I. Ziegler, N. Navab
Real-time fusion of ultrasound and gamma probe for navigated localization of liver metastases
Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2007, LNCS 4792 (2), pp. 909-917 (bib)
T. Wendler, A. Hartl, T. Lasser, J. Traub, F. Daghighian, S. I. Ziegler, N. Navab
Towards intra-operative 3D nuclear imaging: reconstruction of 3D radioactive distributions using tracked gamma probes
Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2 2007, LCNS 4792 (2), pp. 252-260 (bib)
A. Hartl, T. Wendler, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
Towards intra-operative 3D nuclear imaging: development and evaluation of ad hoc models
Proceedings of Jahrestagung der deutschen Gesselschaft für Computer- und Roboterassistierte Chirurgie e.V. (CURAC 2007), Karlsruhe, Germany, October 2007 (bib)
T. Wendler, J. Traub, A. Hartl, T. Lasser, M. Burian, A. K. Buck, F. Daghighian, M. Schwaiger, S. I. Ziegler, N. Navab
Adding navigation to radio-guided surgery: new possibilities, new problems, new solutions
Proceedings of Russian Bavarian Conference on Biomedical Engineering (RBC Biomed 2007), Erlangen, Germany, July 2-3, 2007, pp. 96-100 (bib)
T. Wendler, A. Hartl, J. Traub, S. I. Ziegler, N. Navab
Intraoperative nuclear imaging using navigated gamma-probes for tumor localization
Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2007), Washington D.C., USA, June 2007 (bib)

Clinical Relevance

This project aims currently at applications in breast cancer and melanoma and in particular as assistance in sentinel lymph node biopsy (SLNB). The incidence of these cancer types in 2004 was 124 and 19,6 per 100.000 in the US. The mortality is 24 and 2,6 respectively. SLNB using lymphatic mapping and gamma-probes is part of current state-of-art staging modality in both this cancer types for tumors of grade T2 and T3, but also TX (app. half of the cases). A precise localization of these nodes is not necessary easy in regions with many nodes. The biopsy of a wrong node may imply a wrong prognosis and thus can play a fundamental role in the treatment. In breast the rate of success in localization is in average 89% but varies from 41% to 100%. This is not that dramatic in melanoma, however represents still a relevant problem when aiming at a conservative procedure. The introduced system allows a secure localization without changing the workflow and can be a great assistance and a clear improvement in effectiveness of the treatment.

Team

Contact Person(s)

Aslı Okur Kuru
Dipl.-Inf. Univ. Aslı Okur Kuru
Philipp Matthies
Dipl.-Phys. Univ. Philipp Matthies
Tobias Lasser
PD Tobias Lasser

Working Group

Aslı Okur Kuru
Dipl.-Inf. Univ. Aslı Okur Kuru
Benjamin Frisch
Dr. Benjamin Frisch
Nassir Navab
Prof. Dr. Nassir Navab
Philipp Matthies
Dipl.-Phys. Univ. Philipp Matthies
Sibylle Ziegler
Prof. Dr. Sibylle Ziegler
Tobias Lasser
PD Tobias Lasser

Alumni

Abtin Rasoulian
Abtin Rasoulian
Alexander Hartl
Alexander Hartl
Alexandru Duliu
Dipl.-Inf. Univ. Alexandru Duliu
Andreas Buck
Prof. Dr. Andreas Buck
Berenika Zaraska
Berenika Zaraska
Dzhoshkun Shakir
Dr. Dzhoshkun Shakir
Irene Faure de Pebeyre
Irene Faure de Pebeyre
Joerg Traub
Dr. Joerg Traub
MeiChuan Chen
M.Sc. MeiChuan Chen
Risto Kojcev
Risto Kojcev
Thomas Wendler
Dr. Thomas Wendler
Xinxing Feng
Xinxing Feng

Location



Klinikum rechts der Isar
der Technischen Universitüt München
Ismaninger Str. 22
81675 München

IFL Lab - Room: 01.3a-c
Tel.: +49 89 4140-6457
Fax: +49 89 4140-6458
Visit our lab at Klinikum rechts der Isar.



internal project page

Please contact TobiasLasser, Asli Okur; Philipp Matthies for available student projects within this research project.

Edit | Attach | Refresh | Diffs | More | Revision r1.8 - 13 Sep 2007 - 21:24 - ThomasWendler

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