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Freehand SPECT for Sentinel Lymph Node LocalizationIn medical collaboration with:Prof. Dr. Markus Schwaiger, Chefarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany PD Dr. Andreas Buck, Oberarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Ken Herrmann, Assistenzarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany Prof. Dr. Marion Kiechle, Chefarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Stefan Paepke, Leitender Oberarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Andreas Schnelzer, Oberarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Alexandra Ehlerding, Assistenzarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Prof. Dr. Helmuth Friess, Chefarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Marc Martignoni, Oberarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Jakob Saeckl, Assistenzarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany Prof. Dr. Stefano Fanti, Chefarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy Dr. Ivan Santi, Assistenzarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy Dr. Lorenzo Fantini, Assistenzarzt, Nuklearmedicine, Asienda Ospidaliera S.Orsola-Malpighi, University of Bologna, Bologna, Italy Scientific Director: Nassir Navab, Sibylle Ziegler Contact Person(s): TobiasLasser, Asli Okur; Philipp Matthies In industrial collaboration with: Dr. Joerg Traub, CEO, SurgicEye GmbH, Munich, Germany Dr. Thomas Wendler, CTO, SurgicEye GmbH, Munich, Germany |
Abstract
Nuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging.Publications
| 2020 | |
| A. K. Kogler, A. M. Polemi, S. Nair, S. Majewski, L. T. Dengel, C. L. Slingluff, B. Kross, S. J. Lee, J. E. McKisson?, J. McKisson?, A. G. Weisenberger, B. L. Welch, T. Wendler, P. Matthies, J. Traub, M. Witt, M. B. Williams
Evaluation of camera-based freehand SPECT in preoperative sentinel lymph node mapping for melanoma patients EJNMMI Research 10. https://doi.org/10.1186/s13550-020-00729-8. (bib) |
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| 2016 | |
| T. Wendler, S. Paepke
Axillary sentinel node aspiration biopsy: towards minimally invasive lymphatic staging in breast cancer Clinical and Translational Imaging volume 4, pages377–384. https://doi.org/10.1007/s40336-016-0205-8 (bib) |
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| A. Markus, A. K. Ray, D. Bolla, J. Müller, P.-A. Diener, T. Wendler, R. Hornung
Sentinel lymph node biopsy in endometrial and cervical cancers using freehand SPECT—first experience Gynecological Surgery volume 13, pages499–506. https://doi.org/10.1007/s10397-016-0969-x (bib) |
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| M. N. van Oosterom, T. Engelen, N. S. van den Berg, G. H. KleinJan?, H.G. van der Poel, T. Wendler, C. J. H. van de Velde, N. Navab, F.W.B. van Leeuwen
Navigation of a robot-integrated fluorescence laparoscope in preoperative SPECT/CT and intraoperative freehand SPECT imaging data: a phantom study J Biomed Opt 21(8):86008. https://doi.org/10.1117/1.jbo.21.8.086008 (bib) |
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| G. H. KleinJan?, N. S. van den Berg, M. N. van Oosterom, T. Wendler, M. Miwa, A. Bex, K. Hendricksen, S. Horenblas, F.W.B. van Leeuwen
Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting J Nucl Med 57(10):1650-1653. https://doi.org/10.2967/jnumed.115.171645 (bib) |
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C. Bluemel, P. Matthies, K. Herrmann, S. P. Povoski
3D Scintigraphic Imaging and Navigation in Radioguided Surgery: Freehand SPECT Technology and its Clinical Applications Expert Review of Medical Devices, 2016 (bib) |
| 2015 | |
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T. Lasser, J. Gardiazabal, M. Wieczorek, P. Matthies, J. Vogel, B. Frisch, N. Navab
Towards 3D thyroid imaging using robotic mini gamma cameras Bildverarbeitung für die Medizin, Lübeck, Germany, March 2015 (bib) |
| C. Vetter, T. Lasser, A. Okur, N. Navab
1D-3D Registration for Intra-operative Nuclear Imaging in Radio-guided Surgery IEEE Transactions on Medical Imaging 34(2):608-617, 2015 (bib) |
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A. Hartl, D. I. Shakir, T. Lasser, S. I. Ziegler, N. Navab
Detection models for freehand SPECT reconstruction Physics in Medicine and Biology 60(3):1031-1046, 2015 (bib) |
| 2014 | |
| O. R. Brouwer, N. S. van den Berg, H. M. Mathéron, T. Wendler, H.G. van der Poel, S. Horenblas, R. A. Valdés-Olmos, F.W.B. van Leeuwen
Feasibility of intraoperative navigation to the sentinel node in the groin using preoperatively acquired single photon emission computerized tomography data: transferring functional imaging to the operating room J Urol 192(6):1810-6. https://doi.org/10.1016/j.juro.2014.03.127 (bib) |
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A. Okur, C. Hennersperger, J.B. Runyan, J. Gardiazabal, M. Keicher, S. Paepke, T. Wendler, N. Navab
fhSPECT-US Guided Needle Biopsy of Sentinel Lymph Nodes in the Axilla: Is it Feasible? Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, Lecture Notes in Computer Science Volume 8673, 2014, pp 577-584 (bib) |
| I. Einspieler, A.R. Novotny, A. Okur, M. Essler, M. E. Martignoni
First Experience With Image-guided Resection of Paraganglioma Clinical Nuclear Medicine, Volume 39, Issue:8, August 2014. (bib) |
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A. Okur, R. Voigt, R. Stauder, N. Navab
Investigation of performance log files of freehand SPECT acquisitions for usage characteristics and surgical phase determination The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib) |
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P. Matthies, J. Gardiazabal, A. Okur, J. Vogel, T. Lasser, N. Navab
Mini Gamma Cameras for Intra-operative Nuclear Tomographic Reconstruction Medical Image Analysis 18(8):1329-1336, 2014 (bib) |
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A. Okur, C. Gerngross, A. Schnelzer, A. Ehlerding, M. Keicher, S. Wiesner, S. Paepke, K. Scheidhauer, T. Wendler
First experience with fused ultrasound / freehand SPECT system for hybrid lymphatic mapping in breast cancer patients 52. Jahrestagung der Deutschen Gesellschaft fuer Nuklearmedizin, Hannover, Germany, Mar. 26 - 29, 2014. (bib) |
| A.L. Mihaljevic, A. Rieger, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring innovative freehand SPECT to the operating room: First experiences with sentinel lymph node biopsy in malignant melanoma European Journal of Surgical Oncology (EJSO), Volume 40, Issue 1, January 2014. (bib) |
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| 2013 | |
| J. Gardiazabal, T. Reichl, A. Okur, T. Lasser, N. Navab
First flexible robotic intra-operative nuclear imaging for image-guided surgery Information Processing in Computer Assisted Interventions (IPCAI), Heidelberg, Germany, June 26, 2013 (bib) |
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| C. Bluemel, A. Schnelzer, A. Okur, A. Ehlerding, S. Paepke, K. Scheidhauer, M. Kiechle
Freehand SPECT for image-guided sentinel lymph node biopsy in breast cancer European Journal of Nuclear Medicine and Molecular Imaging. The original publication is available online at www.springerlink.com (bib) |
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| J. Vogel, T. Lasser, J. Gardiazabal, N. Navab
Trajectory optimization for intra-operative nuclear tomographic imaging Medical Image Analysis 17(7):723-731, 2013. (bib) |
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| N. Aubry, E. Auffray, F. B. Mimoun, N. Brillouet, R. Bugalho, , O. Charles, D. Cortinovis, P. Courday, A. Cserkaszky, C. Damon, K. Doroud, J.-M. Fischer, G. Fornaro, J.-M. Fourmigue, B. Frisch, B. Fuerst, J. Gardiazabal, K. Gadow, E. Garutti, C. Gaston, A. Gil-Ortiz, E. Guedj, T. Harion, P. Jarron, J. Kabadanian, T. Lasser, R. Laugier, P. Lecoq, D. Lombardo, S. Mandai, E. Mas, T. Meyer, O. Mundler, N. Navab, C. Ortigão, M. Paganoni, D. Perrodin, M. Pizzichemi, J. O. Prior, T. Reichl, M. Reinecke, M. Rolo, H.-C. Schultz-Coulon, M. Schwaiger, W. Shen, A. Silenzi, J. C. Silva, , I. Somlai-Schweiger, R. Stamen, J. Traub, J. Varela, V. Veckalns, V. Vidal, J. Vishwas, T. Wendler, C. Xu, S. I. Ziegler, M. Zvolsky
EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography JINST 8 C04002. https://doi.org/10.1088/1748-0221/8/04/C04002 (bib) |
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| 2012 | |
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A. Schnelzer, A. Ehlerding, C. Bluemel, A. Okur, K. Scheidhauer, S. Paepke, M. Kiechle
Showcase of Intraoperative 3D Imaging of the Sentinel Lymph Node in a Breast Cancer Patient using the New Freehand SPECT Technology Breast Care 2012;7:484-486 (bib) |
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J. Vogel, T. Reichl, J. Gardiazabal, N. Navab, T. Lasser
Optimization of Acquisition Geometry for Intra-operative Tomographic Imaging Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nice, France, October 2012 (bib) |
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I. Einspieler, A. Okur, A.R. Novotny, M. E. Martignoni, K. Scheidhauer
Case Report - Image-guided Resection of Paraganglioma 32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib) |
| A. Rieger, J. Saeckl, R. Hein, A. Okur, T. Wendler, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring Innovative Freehand SPECT to the Operating Room - First Experiences with Sentinel Lymphonodectomy in Malignant Melanoma 32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib) |
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N. Navab, T. Blum, L. Wang, A. Okur, T. Wendler
First Deployments of Augmented Reality in Operating Rooms IEEE Computer, Volume 45, Issue 7, pp. 48-55 (bib) |
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C. Bluemel, A. Schnelzer, A. Rieger, A. Ehlerding, A. Okur, C. Gerngross, M. E. Martignoni, K. Scheidhauer, M. Schwaiger
3D navigated (radio-guided) sentinel lymph node biopsy using freehand SPECT : final evaluation of Munich's pilot experience in the operating room 50. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Messe Bremen, Germany, April 2012 (bib) |
| A. Hartl, D. I. Shakir, R. Kojchev, N. Navab, S. I. Ziegler, T. Lasser
Freehand SPECT reconstructions using look up tables SPIE Medical Imaging Conference, February 4 - February 9 2012, San Diego, USA (bib) |
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| 2011 | |
| C. Vetter, T. Lasser, T. Wendler, N. Navab
1D-3D Registration for Functional Nuclear Imaging Medical Image Computing and Computer Assisted Intervention (MICCAI), Toronto, Canada, September 20-24 2011. (bib) |
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| A. Okur, A. Ahmadi, A. Bigdelou, T. Wendler, N. Navab
MR in OR: First analysis of AR/VR visualization in 100 intra-operative Freehand SPECT acquisitions The 10th IEEE and ACM International Symposium on Mixed and Augmented Reality (ISMAR), Basel, Switzerland, Oct. 26 - 29, 2011. (bib) |
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| A. Hartl, T. Lasser, N. Navab, S. I. Ziegler
Impact of acquisition geometry and physical model on Freehand SPECT reconstructions IEEE Medical Imaging Conference, October 23 - October 29 2011, Valencia, Spain (bib) |
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| C. Bluemel, A. Schnelzer, A. Ehlerding, A. Okur, K. Scheidhauer, M. Kiechle, M. Schwaiger
Evaluation of freehand SPECT in sentinel lymph node biopsy of breast cancer Proceedings of the Annual Congress of the European Association of Nuclear Medicine (EANM), Birmingham, UK, October 2011 (bib) |
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A. Rieger, J. Saeckl, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Wendler, J. Traub, H. Friess, M. E. Martignoni
First Experiences with Navigated Radio-Guided Surgery Using Freehand SPECT Case Reports in Oncology, August 2011 (bib) |
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A. Okur, C. Bluemel, A. Ehlerding, K. Scheidhauer, A. Schnelzer
Meme kanseri cerrahisinde freehandSPECT ile ilk tecrube: Aksiller sentinel lenf nodu biyopsisinde uc boyutlu navigasyon ve kalite guvencesi XI. Ulusal Meme Hastaliklari Kongresi, Antalya, Turkey, Oct. 5 - 9, 2011. (bib) |
| C. Lapa, J. Saeckl, A. Rieger, C. Bluemel, A. Okur, T. Wendler, M. E. Martignoni, K. Scheidhauer
Investigating added value of freehand SPECT in sentinel node biopsy of melanomas Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib) |
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| C. Bluemel, A. Ehlerding, C. Lapa, A. Okur, T. Wendler, A. Schnelzer, K. Scheidhauer
Improvements in sentinel node biopsy of breast cancer using freehand SPECT Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib) |
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| 2010 | |
| T. Wendler, T. Lasser, S. I. Ziegler, K. Scheidhauer
Freehand SPECT/US: new approach for intraoperative hybrid imaging of sentinel nodes Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| T. Wendler, D. Zaeuner, S. Wiesner, K. Scheidhauer
Fused SPECT/CT and real-time video visualization for intraoperative guidance in SLNB of head and neck malignancies Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| K. Scheidhauer, A. Ehlerding, J. Saeckl, A. Rieger, K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Wendler
Feasibility evaluation of freehand SPECT for intraoperative 3D lymphatic mapping Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, S. Nicolini, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT 3D-imaging for sentinel lymph node mapping in breast cancer: preliminary preoperative study for future intraoperative use in the operating room Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| M. C. Kreissl, T. Wendler, K. Herrmann, K. Scheidhauer
Freehand SPECT: First experiences with a new method of 3D-SLN mapping in melanoma Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT for sentinel lymph node biopsy: first clinical experience Proceedings of EANM 2010, Vienna, Austria, October 2010 (bib) |
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| A. K. Buck, A. Ehlerding, J. Saeckl, K. Herrmann, T. Wendler, M. E. Martignoni, A. Schnelzer, M. Schwaiger
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of EANM 2010, Vienna, Austria, October 2010 (bib) |
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| A. Schnelzer, A. Ehlerding, T. Chen, T. Wendler, K. Scheidhauer, S. Paepke, M. Kiechle
Sentinel lymph node detection with intraoperative freehand SPECT in breast cancer patients Proceedings of the Annual Meeting of the German Society of Gynecology and Obstetrics (DGGG) 2010, Munich, Germany, October 2010 (bib) |
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| A. Ehlerding, A. Schnelzer, T. Wendler, K. Herrmann, T. Lasser, K. Scheidhauer, O. Kutter, T. Schuster, M. Schwaiger, A. K. Buck, S. I. Ziegler, N. Navab, S. Paepke, M. Kiechle
Vorstellung der Pilotstudie zur 3D-Darstellung des Wächterlymphknotens bei Brustkrebspatientinnen mittels Freehand-SPECT Proceedings of Annual Meeting of the German Society of Senology (DGS), Hamburg, Germany, Jul. 2010 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Lasser, J. Traub, A. Ehlerding, J. Saeckl, N. Navab, M. Kiechle, H. Friess, M. Schwaiger, S. I. Ziegler, A. K. Buck
Visione 3-D SPECT intraoperatoria: una nuova metodica per chirurgia radioguiata Proceedings of SICO 2010, Milan, Italy, June 2010 (bib) |
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| I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT for sentinel lymph node biopsy: first clinical experience Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib) |
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| M. C. Kreissl, A. Okur, T. Chen, A. Bartel, T. Wendler, K. Scheidhauer
Pilot study of freehand SPECT for lymphatic mapping in melanoma in upper body Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib) |
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| K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Wendler, A. K. Buck
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, A. Ehlerding, K. Scheidhauer, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First Demonstration of 3D Lymphatic Mapping using freehand SPECT Proceedings of the International Conference on Sentinel Node Biopsy and Radioguided Head & Neck Surgery (SNB), Copenhagen, Denmark, May 2010 (bib) |
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| J. Saeckl, A. Ehlerding, K. Herrmann, T. Wendler, M. Schwaiger, M. Kiechle, H. Friess, A. K. Buck, A. Schnelzer, M. E. Martignoni
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of the International Conference on Sentinel Node Biopsy and Radioguided Head & Neck Surgery (SNB), Copenhagen, Denmark, May 2010 (bib) |
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| A. K. Buck, A. Schnelzer, T. Wendler, K. Herrmann, T. Lasser, J. Traub, O. Kutter, T. Schuster, A. Ehlerding, K. Scheidhauer, M. Kiechle, N. Navab, S. I. Ziegler, M. Schwaiger
First demonstration of 3D lymphatic mapping in breast cancer using freehand SPECT Proceedings of DGN Nuklearmedizin 2010, Leipzig, Germany, April 2010 (bib) |
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| K. Herrmann, A. Schnelzer, T. Wendler, M. Hoyer, D. Weisgerber, T. Lasser, S. Paepke, M. E. Martignoni, M. Kiechle, N. Navab, S. I. Ziegler, M. Schwaiger
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of DGN Nuklearmedizin 2010, Leipzig, Germany, April 2010 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, A. Ehlerding, K. Scheidhauer, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First demonstration of 3-D lymphatic mapping in breast cancer using freehand SPECT European Journal of Nuclear Medicine and Molecular Imaging, Springer Berlin/Heidelberg, 2010 Aug;37(8):1452-61. Epub 2010 Mar 31. (bib) |
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| 2009 | |
| J. Traub, K. Herrmann, T. Lasser, N. Navab, S. I. Ziegler, A. K. Buck, T. Wendler
Freehand SPECT/Ultrasound Fusion for Hybrid Image-guided Resection Proceedings of RSNA 2009, Chicago, USA, December 2009 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
Clinical introduction of freehand SPECT for image-guided sentinel lymph node biopsy Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Wendler, X. Feng, K. Herrmann, T. Lasser, J. Traub, S. I. Ziegler, N. Navab, A. K. Buck
2D/3D registration of freehand SPECT and planar scintigraphy for clinical evaluation of 3D thyroid scintigraphy Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Wendler, K. Herrmann, T. Lasser, J. Traub, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First experience with freehand SPECT for lymphatic mapping in melanoma in upper body Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Wendler, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
Freehand SPECT / ultrasound fusion for hybrid image-guided resection Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Lasser, A. Duliu, T. Wendler, S. I. Ziegler, N. Navab
Interactive Reconstruction for Freehand SPECT: An Approach to Acquisition Guidance? Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| X. Feng, K. Szajkowska, T. Lasser, S. I. Ziegler, N. Navab, T. Wendler
2D/3D registration of freehand SPECT and planar scintigraphy for clinical evaluation of 3D thyroid scintigraphy Proceedings of World Congress in Medical Physics and Biomedical Engineering (WC 2009), Munich, Germany, September 2009 (bib) |
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| J. Traub, K. Herrmann, T. Wendler, T. Lasser, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First clinical results of freehand SPECT for lymphatic mapping in breast cancer Proceedings of the Molekulare Bildgebung (MOBI), Berlin, Germany, Jun. 2009 (bib) |
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| T. Wendler, K. Herrmann, T. Lasser, J. Traub, M. Schwaiger, S. I. Ziegler, N. Navab, A. K. Buck
Freehand SPECT: first in-vivo evaluation and comparison to conventional lymphatic mapping Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2009), Toronto, Canada, June 2009 (bib) |
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| T. Wendler, X. Feng, T. Lasser, K. Herrmann, J. Traub, K. Scheidhauer, S. I. Ziegler, D. Lenhart, J. Grahneis, M. Schwaiger, N. Navab, A. K. Buck
Freehand SPECT for 3D thyroid scintigraphy: first patient report Proceedings of DGN Nuklearmedizin 2009, Leipzig, Germany, April 2009 (bib) |
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| K. Herrmann, T. Wendler, T. Chen, A. Bartel, T. Lasser, K. Scheidhauer, J. Traub, T. Schuster, S. I. Ziegler, M. Schwaiger, A. K. Buck, N. Navab
Freehand SPECT: first in-vivo use for lymphatic mapping and comparison to conventional imaging Proceedings of DGN Nuklearmedizin 2009, Leipzig, Germany, April 2009 (bib) |
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| 2008 | |
| T. Wendler, T. Lasser, A. K. Buck, C. Özgür, M. Schwaiger, S. I. Ziegler, N. Navab
First in Vivo Use of a Fused Gamma Ultrasound System Proceedings of RSNA 2008, Chicago, USA, December 2008 (bib) |
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| T. Wendler, T. Lasser, S. I. Ziegler, N. Navab
Towards Confident 3D Tomographic Reconstruction for Asymmetric, Sparse Detector Geometries Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib) |
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| T. Lasser, T. Wendler, S. I. Ziegler, N. Navab
Towards Reproducibility of Freehand 3D Tomographic Nuclear Imaging Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib) |
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| T. Lasser, T. Wendler, J. Traub, S. I. Ziegler, N. Navab
Definition of optimal collimator geometries for 3D tomographic thyroid scintigraphy using navigated gamma probes Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008 (bib) |
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| T. Wendler, T. Lasser, A. K. Buck, J. Traub, M. Schwaiger, S. I. Ziegler, N. Navab
First case report of 3D tomographic thyroid scintigraphy with tracked gamma probes Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008, Eur J Nuc Med Mol Imaging, vol. 35 (Suppl. 2), S129 (bib) |
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| T. Wendler, J. Traub, T. Lasser, M. Feuerstein, J. Vogel, S. I. Ziegler, N. Navab
Combined ultrasound and gamma probe imaging for examination of thyroid nodules Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib) |
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| T. Wendler, A. Hartl, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
3D Intra-operative nuclear imaging for SLNB in neck Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib) |
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| N. Navab, J. Traub, A. K. Buck, S. I. Ziegler, T. Wendler
Navigated nuclear probes for intra-operative functional imaging Proceedings of 5th IEEE International Symposium on Biomedical Imaging (ISBI 2008), Paris, France, May 14 - 17 2008, pp. 1395-1398 (bib) |
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| 2007 | |
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T. Wendler, M. Feuerstein, J. Traub, T. Lasser, J. Vogel, F. Daghighian, S. I. Ziegler, N. Navab
Real-time fusion of ultrasound and gamma probe for navigated localization of liver metastases Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2007, LNCS 4792 (2), pp. 909-917 (bib) |
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T. Wendler, A. Hartl, T. Lasser, J. Traub, F. Daghighian, S. I. Ziegler, N. Navab
Towards intra-operative 3D nuclear imaging: reconstruction of 3D radioactive distributions using tracked gamma probes Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2 2007, LCNS 4792 (2), pp. 252-260 (bib) |
| A. Hartl, T. Wendler, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
Towards intra-operative 3D nuclear imaging: development and evaluation of ad hoc models Proceedings of Jahrestagung der deutschen Gesselschaft für Computer- und Roboterassistierte Chirurgie e.V. (CURAC 2007), Karlsruhe, Germany, October 2007 (bib) |
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T. Wendler, J. Traub, A. Hartl, T. Lasser, M. Burian, A. K. Buck, F. Daghighian, M. Schwaiger, S. I. Ziegler, N. Navab
Adding navigation to radio-guided surgery: new possibilities, new problems, new solutions Proceedings of Russian Bavarian Conference on Biomedical Engineering (RBC Biomed 2007), Erlangen, Germany, July 2-3, 2007, pp. 96-100 (bib) |
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T. Wendler, A. Hartl, J. Traub, S. I. Ziegler, N. Navab
Intraoperative nuclear imaging using navigated gamma-probes for tumor localization Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2007), Washington D.C., USA, June 2007 (bib) |
Clinical Relevance
This project aims currently at applications in breast cancer and melanoma and in particular as assistance in sentinel lymph node biopsy (SLNB). The incidence of these cancer types in 2004 was 124 and 19,6 per 100.000 in the US. The mortality is 24 and 2,6 respectively. SLNB using lymphatic mapping and gamma-probes is part of current state-of-art staging modality in both this cancer types for tumors of grade T2 and T3, but also TX (app. half of the cases). A precise localization of these nodes is not necessary easy in regions with many nodes. The biopsy of a wrong node may imply a wrong prognosis and thus can play a fundamental role in the treatment. In breast the rate of success in localization is in average 89% but varies from 41% to 100%. This is not that dramatic in melanoma, however represents still a relevant problem when aiming at a conservative procedure. The introduced system allows a secure localization without changing the workflow and can be a great assistance and a clear improvement in effectiveness of the treatment.Team
Contact Person(s)
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Working Group
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Alumni
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Klinikum rechts der Isar der Technischen Universitüt München Ismaninger Str. 22 81675 München IFL Lab - Room: 01.3a-c Tel.: +49 89 4140-6457 Fax: +49 89 4140-6458 |
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internal project page
Please contact TobiasLasser, Asli Okur; Philipp Matthies for available student projects within this research project.
