O. Zettinig, T. Mansi, B. Georgescu, E. Kayvanpour, F. Sedaghat-Hamedani, A. Amr, J. Haas, H. Steen, B. Meder, H. Katus, N. Navab, A. Kamen, D. Comaniciu Fast Data-Driven Calibration of a Cardiac Electrophysiology Model from Images and ECG Proceedings of the 16th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nagoya, Japan, September 2013. The original publication is available online at link.springer.com (bib)
	Recent advances in computational electrophysiology (EP) models make them attractive for clinical use. We propose a novel data-driven approach to calibrate an EP model from standard 12-lead electrocardiograms (ECG), which are in contrast to invasive or dense body surface measurements widely available in clinical routine. With focus on cardiac depolarization, we first propose an efficient forward model of ECG by coupling a mono-domain, Lattice-Boltzmann model of cardiac EP to a boundary element formulation of body surface potentials. We then estimate a polynomial regression to predict myocardium, left ventricle and right ventricle endocardium electrical diffusion from QRS duration and ECG electrical axis. Training was performed on 4,200 ECG simulations, calculated in ca. 3s each, using different diffusion parameters on 13 patient geometries. This allowed quantifying diffusion uncertainty for given ECG parameters due to the ill-posed nature of the ECG problem. We show that our method is able to predict myocardium diffusion within the uncertainty range, yielding a prediction error of less than 5ms for QRS duration and 2deg for electrical axis. Prediction results compared favorably with those obtained with a standard optimization procedure, while being 60 times faster. Our data-driven model can thus constitute an efficient preliminary step prior to more refined EP personalization.
	This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each authors copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.