X. Feng, K. Szajkowska, T. Lasser, S. I. Ziegler, N. Navab, T. Wendler 2D/3D registration of freehand SPECT and planar scintigraphy for clinical evaluation of 3D thyroid scintigraphy Proceedings of World Congress in Medical Physics and Biomedical Engineering (WC 2009), Munich, Germany, September 2009 (bib)
	Thyroid planar scintigraphy is a standard technique in Nuclear Medicine. The clear information it provides it has allowed it to live for decades. Freehand SPECT has been introduced lately as a 3D imaging modality for small anatomies []. In this work, the freehand SPECT technology is applied for the first time for 3D thyroid scintigraphy. A first trial in 10 thyroid patients (40-78y, mean 61) was performed for the purposes of testing and evaluation of this technology in a pilot study setup. For validation a 2D/3D registration method was designed and implemented in order to compared conventional 2D thyroid scintigraphy with the new 3D freehand SPECT images. Further the accuracy of the 2D/3D registration appli-cation was evaluated with a synthetic 3D thyroid shape and known rigid transformation. The 2D/3D registration for the synthetic data were bold and the ones of the patient data sets reveal that the freehand SPECT is a promising approach that may open new doors in Nuclear Medicine.
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