Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

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L. Peter, O. Pauly, S. Jansen, P. Smethurst, W. Ouwehand , N. Navab
Automatic Event Detection within Thrombus Formation Based on Binary Integer Programming
MICCAI Workshop on Medical Computer Vision, Nice, France, October 2012 (bib)

After a blood vessel injury, blood platelets progressively aggregate on the damaged site to stop the resulting blood loss. This natural mechanism called thrombosis can however be prone to malfunctions and lead to the complete obstruction of the blood vessel. Thrombosis disorders play a crucial role in coronary artery diseases and the identification of genetic risk predispositions would therefore considerably help their diagnosis and therapy. In vitro experiments are conducted in this purpose by perfusing blood from several donors over a surface of collagen fibres, which results in the progressive attachment of platelets. Based on the segmentation over time of these aggregates called thrombi, we propose in this paper an automatic method combining tracking and event detection which allows the extraction of characteristics of interest for each thrombus growth individually, in order to find a potential correlation between these growth features and blood donors genetic disorders. We demonstrate the benefits of our approach and the accuracy of its results through an experimental validation.
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