WolfgangWein

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

Wolfgang Wein Dr. Wolfgang Wein



ImFusion GmbH, Munich, Germany

Opportunities

We are currently looking for students for internships and student projects. Please check the job page at ImFusion for more details. Open projects right now are:

Short Profile

I am CEO of the R&D lab ImFusion and a senior research scientist in the field of medical image computing, working in the interdisciplinary cross-section of computer science, physics and medicine. Recent research focuses on improved 3D cone-beam X-Ray reconstruction techniques, including novel motion compensation approaches. Another area of interest (based on prior work at Siemens Corporate Research, Princeton), is ultrasound-based interventional navigation in various clinical specialties and all its associated computational challenges.

Dissertation


Title: Multimodal Integration of Medical Ultrasound for Treatment Planning and Interventions
Abstract:
Ultrasound is a popular, cost-effective and non-invasive medical imaging modality. If an ultrasound probe is equipped with a 3D position sensor, the acquired images can be obtained in their spatial context, a technique commonly denoted "3D freehand ultrasound".
Combining ultrasound and a pre-operative Computed Tomography (CT) scan of the same patient can be beneficial for a number of clinical applications. The core of this thesis is the development of novel methods for fully automatic alignment (i.e. registration) of 3D freehand ultrasound and CT data, based on the image content and the physical properties of both modalities.
In particular, a new method is proposed which simultaneously optimizes the linear combination of different ultrasonic effects simulated from CT, and the parameters for spatial alignment. This original concept allows local as well as global optimization of the simulation parameters, resulting in optimal registration of any modalities, where usual registration solutions do not succeed and explicit simulation of complex effects are necessary.
Furthermore, we introduce new techniques for 3D freehand ultrasound calibration and reconstruction, as well as visualization of fused CT and ultrasound data.
Two clinical applications are investigated in detail. We use a designated version of an automatic registration algorithm to integrate diagnostic ultrasound into radiation treatment planning for head and neck cancer. Our simultaneous optimization of simulation and registration is applied, in the context of treating liver and kidney metastases, for fusing CT with both diagnostic and interventional ultrasound of the abdomen. While diagnostic fusion helps doctors to assess indeterminate lesions in those organs, interventional fusion using our techniques allows for advanced image-guided navigation, in particular, for needle biopsies and radio-frequency ablations.
CTUSFusion.jpg
AbdominalFusion.jpg

Dissertation Download as PDF

Publications

2016
O. Zettinig, B. Fuerst, R. Kojcev, M. Esposito, M. Salehi, W. Wein, J. Rackerseder, B. Frisch, N. Navab
Toward Real-time 3D Ultrasound Registration-based Visual Servoing for Interventional Navigation
IEEE International Conference on Robotics and Automation (ICRA), Stockholm, May 2016 (bib)
2015
M. Salehi, A. Ahmadi, R. Prevost, N. Navab, W. Wein
Patient-specific 3D Ultrasound Simulation Based on Convolutional Ray-tracing and Appearance Optimization
MICCAI 2015, the 18th International Conference on Medical Image Computing and Computer Assisted Interventions (bib)
2014
M. Müller, L.E.S. Helljesen, R. Prevost, I. Viola, K. Nylund, O.H. Gilja, N. Navab, W. Wein
Deriving Anatomical Context from 4D Ultrasound
Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM), September 3-5 2014, Vienna, Austria (bib)
B. Fuerst, W. Wein, M. Müller, N. Navab
Automatic Ultrasound-MRI Registration for Neurosurgery using the 2D and 3D LC2 Metric
Medical Image Analysis, 2014(18), pp. 1312-1319. (bib)
2013
W. Wein, A. Ladikos, B. Fuerst, A. Shah, K. Sharma, N. Navab
Global Registration of Ultrasound to MRI using the LC2 Metric for Enabling Neurosurgical Guidance
Proceedings of the 16th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nagoya, Japan, September 2013 (bib)
W. Wein, A. Ladikos
Towards General Motion Recovery in Cone-Beam Computed Tomography
12th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, June 16-21 2013, Lake Tahoe, CA USA (bib)
2012
A. Ladikos, W. Wein
Geometric calibration using bundle adjustment for cone-beam computed tomography devices
SPIE Medical Imaging, February 2012, San Diego, USA. (bib)
O. K. Oye, W. Wein, D. M. Ulvang, K. Matre, I. Viola
Real Time Image-Based Tracking of 4D Ultrasound Data
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2012), Nice, France, October 2012 (bib)
A. Aichert, W. Wein, A. Ladikos, T. Reichl, N. Navab
Image-based tracking of the teeth for orthodontic augmented reality
Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nice, France, October 2012 (bib)
J. Beitzel, A. Ahmadi, A. Karamalis, W. Wein, N. Navab
Ultrasound Bone Detection Using Patient-Specific CT Prior
International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), San Diego, USA, September 1 2012. (bib)
V. Solteszova, L.E.S. Helljesen, W. Wein, O.H. Gilja, I. Viola
Lowest-Variance Streamlines for Filtering of 3D Ultrasound
Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM) 2012, Norrköping, Sweden, September 2012 (bib)
A. Karamalis, W. Wein, T. Klein, N. Navab
Ultrasound Confidence Maps using Random Walks
Medical Image Analysis, 16, 6, 1101 - 1112, 2012, DOI: http://dx.doi.org/10.1016/j.media.2012.07.005 (bib)
2011
L. Grady, S. Datta, O. Kutter, C. Duong, W. Wein, S. Little, X. Liu, M. Vannan
Regurgitation Quantification using 3D PISA in Volume Echocardiography
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2011), Toronto, Canada, September 2011 (bib)
W. Wein, A. Ladikos
Detecting Patient Motion in Projection Space for Cone-beam Computed Tomography
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2011), Toronto, Canada, September 2011 (bib)
W. Wein, A. Ladikos, A. Baumgartner
Self-calibration of geometric and radiometric parameters for cone-beam computed tomography
11th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, July 11-15 2011, Potsdam, Germany. (bib)
2010
O. Fluck, C. Vetter, W. Wein, A. Kamen, B. Preim, R. Westermann
A survey of medical image registration on graphics hardware
Computer Methods and Programs in Biomedicine, November 2010 (bib)
A. Karamalis, W. Wein, N. Navab
Fast Ultrasound Image Simulation using the Westervelt Equation
In Proc. International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), Beijing, China, September 20-24, 2010 (bib)
C. Weiss, M. Seitz, K. Herrmann, A. Graser, B. Kiefer, M. Requardt, J. Fehre, R. Nanke, M. Diallo, A. Kamen, W. Wein
MR-US Fusion for Targeted Prostate Biopsy
International Society for Magnetic Resonance in Medicine (ISMRM) conference, Stockholm, Sweden, May 2010 (bib)
W. Wein, O. Kutter, A. Aichert, D. Zikic, A. Kamen, N. Navab
Automatic non-linear mapping of pre-procedure CT volumes to 3D ultrasound
IEEE International Symposium on Biomedical Imaging (ISBI), Rotterdam, The Netherlands, April 14 - 17 2010. (bib)
2009
W. Wein, E. Camus, M. John, M. Diallo, C. Duong, A. Al-Ahmad, R. Fahrig, A. Khamene, C. Xu
Towards Guidance of Electrophysiological Procedures with Real-time 3D Intracardiac Echocardiography Fusion to C-arm CT
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2009), London, UK, September 2009 (bib)
O. Kutter, W. Wein, N. Navab
Multi-modal registration based Ultrasound Mosaicing
Medical Image Computing and Computer-Assisted Intervention (MICCAI), London, UK, September 20-24 2009 (bib)
N. Fritz, T. Meyer, T. Blum, H.U. Lemke, M. Ilzkovitz, Y. Nevatia, M. Nolden, I. Wegner, M. Weinlich, R. Breitkreutz, W. Wein, M. Lazerges, O. Angerer, N. Navab
CAMDASS: An Augmented Reality Medical Guidance System for Spaceflights
Proceedings of Computer Assisted Radiology and Surgery (CARS 2009), Berlin, Germany, June 2009 (bib)
O. Kutter, A. Karamalis, W. Wein, N. Navab
A GPU-Based Framework for Simulation of Medical Ultrasound
SPIE Medical Imaging, Orlando, Florida, USA, February 2009 (bib)
A. Karamalis, W. Wein, O. Kutter, N. Navab
Fast Hybrid Freehand Ultrasound Volume Reconstruction
In Proc. SPIE Medical Imaging, Orlando, Florida, USA, February 2009 (bib)
2008
C. Wachinger, W. Wein, N. Navab
Registration Strategies and Similarity Measures for Three-dimensional Ultrasound Mosaicing
Journal of the University Radiologists, Academic Radiology 15 (11), pp.1404-1415. Special issue of MICCAI 2007 (bib)
W. Wein, S. Brunke, A. Khamene, M.R. Callstrom, N. Navab
Automatic CT-Ultrasound Registration for Diagnostic Imaging and Image-guided Intervention
Medical Image Analysis 12(5), pp 577-585, October 2008 (bib)
W. Wein, J.-Z. Cheng, A. Khamene
Ultrasound based Respiratory Motion Compensation in the Abdomen
MICCAI 2008 Workshop on Image Guidance and Computer Assistance for Soft-Tissue Interventions, September 10 2008, New York City, USA. (bib)
F. Bender, M. Groher, A. Khamene, W. Wein, H. Heibel, N. Navab
3D Dynamic Roadmapping for Abdominal Catheterizations
Medical Image Computing and Computer-Assisted Intervention, MICCAI, 2008, New York, USA, September 6-10 2008 (bib)
W. Wein, A. Khamene
Image-Based Method for In-Vivo Freehand Ultrasound Calibration
SPIE Medical Imaging, 16-21 February 2008, San Diego, California USA (bib)
2007
W. Wein, A. Khamene, D.-A. Clevert, O. Kutter, N. Navab
Simulation and Fully Automatic Multimodal Registration of Medical Ultrasound
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007. Received the MICCAI 2007 Young Scientist Award. (bib)
W. Wein, M. Blume, U. Leischner, H.-U. Dodt, N. Navab
Quality-based Registration and Reconstruction of Optical Tomography Volumes
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007 (bib)
C. Wachinger, W. Wein, N. Navab
Three-Dimensional Ultrasound Mosaicing
Medical Image Computing and Computer-Assisted Intervention, MICCAI, 2007, Brisbane, Australia, October 29 - November 2 2007 (bib)
M. Blume, D. Zikic, W. Wein, N. Navab
A New and General Method for Blind Shift-Variant Deconvolution of Biomedical Images
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007 (bib)
C. Wachinger, W. Wein, N. Navab
Ultrasound Volume Stitching
6. Jahrestagung der Deutschen Gesellschaft für Computer-und Roboter-Assistierte Chirurgie (CURAC 2007), Karlsruhe, Germany, October 2007 (bib)
W. Wein, B. Röper, N. Navab
Integrating diagnostic B-mode ultrasonography into CT-based radiation treatment planning
IEEE Transactions on Medical Imaging, 26 (June 2007), pp. 866–879 (bib)
M.S. Burns, M. Haidacher, W. Wein, I. Viola, E. Gröller
Feature Emphasis and Contextual Cutaways for Multimodal Medical Visualization
EuroVis 2007 conference, Norrköping, Sweden, May 2007 (link) (bib)
M. John, Y. Sun, S. Kadoury, W. Wein, Y. Li, J. Resnick, G. Plambeck, A. Dempsey, A. Al-Ahmad, R. Fahrig, F. Sauer
Fusion of Intracardiac Ultrasound with 3D Cardiac C-arm CT from Animal Data for Electrophysiology
Bildverarbeitung für die Medizin, Munich, Germany, March 2007 (bib)
2006
D. Zikic, W. Wein, A. Khamene, D.-A. Clevert, N. Navab
Fast Deformable Registration of 3D-Ultrasound Using a Variational Approach
Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006 (bib)
W. Wein, F. Pache, B. Röper, N. Navab
Backward-Warping Ultrasound Reconstruction for Improving Diagnostic Value and Registration
Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006 (bib)
B. Röper, W. Wein, P. Kneschaurek, M. Molls, M. Dobritz, N. Navab
Image-based fusion of diagnostic ultrasound and planning CT for radiotherapy of head and neck cancer – a way towards improvement of regional target volume delineation
12. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), May 2006, Dresden, Germany (bib)
A. Khamene, P. Bloch, W. Wein, M. Svatos, F. Sauer
Automatic Registration of Portal Images and Volumetric CT for Patient Positioning in Radiation Therapy
Medical Image Analysis 10 (2006), pages 96-112 (bib)
A. Khamene, R. Chisu, W. Wein, N. Navab, F. Sauer
A Novel Projection Based Approach for Medical Image Registration
Third International Workshop on Biomedical Image Registration (WBIR), 9-11 July 2006, Utrecht, The Netherlands. (bib)
2005
W. Wein, B. Röper, N. Navab
Automatic Registration and Fusion of Ultrasound with CT for Radiotherapy
8th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), October 2005, Palm Springs, California USA. (bib)
W. Wein, B. Röper, N. Navab
2D/3D Registration Based on Volume Gradients
SPIE Medical Imaging, 12-17 February 2005, San Diego, California USA (bib)
2004
W. Wein, B. Röper, N. Navab
2D/3D Registration Based on Volume Gradients
CURAC, October 2004, Munich (bib)
G. Klinker, H. Najafi, T. Sielhorst, F. Sturm, F. Echtler, M. Isik, W. Wein, C. Truebswetter
FixIt: An Approach towards Assisting Workers in Diagnosing Machine Malfunctions
Proc. of the International Workshop on Design and Engineering of Mixed Reality Systems - MIXER 2004, Funchal, Madeira, CEUR Workshop Proceedings (bib)
2003
T. Reicher, Chr. Schwingenschlögl, W. Wein
Network Emulation for Application Development in Heterogeneous Networks
8th International Workshop on Mobile Multimedia Communications, Munich, Germany, Oct. 7, 2003. (bib)

Teaching

Wintersemester 2012/2013

Wintersemester 2011/2012

Wintersemester 2004/2005

Sommersemester 2004

  • Tutorial of lecture 3D Computer Vision?
  • Praktikum Intra-operative Imaging & Visualization?
  • Seminar Methods & Tools of Medical Imaging?

Wintersemester 2003/2004

  • Lecture Intra-operative Imaging & Visualization?

Supervision

Diploma Thesis

My Diploma Thesis with the title Intensity Based Rigid 2D-3D Registration Algorithms for Radiation Therapy .

Curriculum Vitae

  • 10/1999 - 01/2004: Computer science (minor physics) at Technische Universität München.
  • 02/2001 - 04/2001: Internship at the IT department of the Infineon maskhouse (MH DPT), Munich (evaluation of log files of litographic mask writers for statistical process control).
  • 02/2002 - 04/2002: Interdisciplinary project at the new experimental nuclear reactor FRM-II in Garching (development of a framework for network based instrument control of neutron scattering experiments).
  • 07/2002 - 09/2002: Participation in the IBM Extreme Blue Summer Internship in Boeblingen. I was working in the Life Science project and developed an integrated 2D/3D chemical structure editor.
  • 04/2003 - 10/2003: Internship at Siemens Corporate Research , Princeton, USA. Within the scope of my diploma thesis I was working on 2D/3D registration for patient positioning in radiation therapy.
  • 11/2003 - 02/2006: Ph.D. student at the new chair I16 of Prof. Nassir Navab, in collaboration with Siemens Corporate Research.
  • 03/2006 - 04/2010: Research Scientist at Siemens Corporate Research, Princeton NJ USA.
  • 05/2010 - 07/2012: CTO at White Lion Technologies AG, Munich, Germany.
  • 08/2012 - today: CEO at ImFusion GmbH, Munich, Germany.

UsersForm
Title: Dr.
Circumference of your head (in cm):  
Firstname: Wolfgang
Middlename:  
Lastname: Wein
Picture: weinwolfgangicon.png
Birthday:  
Nationality: Germany
Languages: English, German, Bavarian
Groups: Registration/Visualization, Reconstruction, Medical Imaging, Molecular Imaging, Computer-Aided Surgery
Expertise: Registration/Visualization, Medical Imaging, Molecular Imaging, Computer-Aided Surgery, 3D Information Presentation
Position: External Collaborator
Status: Alumni
Emailbefore: wein
Emailafter: cs.tum.edu
Room: MI 03.13.057
Telephone:  
Alumniactivity: CEO at ImFusion GmbH, Munich, Germany
Defensedate: 12 October 2007
Thesistitle: Multimodal Integration of Medical Ultrasound for Treatment Planning and Interventions
Alumnihomepage:  
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Personalvideotext01:  
Personalvideopreview01:  
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