Prostate Fusion Biopsy In medical collaboration with: Poliklinik und Klinik für Urologie, Klinikum Rechts der Isar Klinik für Nuklearmedizin, Klinikum Rechts der Isar Scientific Director: Nassir Navab and Christoph Hennersperger Contact Person(s): Beatrice Demiray

Keywords: Registration / Visualization, Segmentation, Medical Imaging, Computer-Aided Surgery, IFL

Abstract

Transrectal ultrasound (TRUS) guided biopsy remains the gold standard for diagnosis. However, it suffers from low sensitivity, leading to an elevated rate of false negative results. On the other hand, the recent advent of PET imaging using a novel dedicated radiotracer, Ga-labelled PSMA (Prostate Specific Membrane Antigen), combined with MR provides improved preinterventional identification of suspicious areas. Thus, MRI/TRUS fusion image-guided biopsy has evolved to be the method of choice to circumvent the limitations of TRUS-only biopsy. We propose a multimodal fusion image-guided biopsy framework that combines PET-MRI images with TRUS. Based on open-source software libraries, it is low cost, simple to use and has minimal overhead in clinical workflow. It is ideal as a research platform for the implementation and rapid bench to bedside translation of new image registration and visualization approaches.

Publications

2017
	O. Zettinig, J. Rackerseder, B. Lentes, T. Maurer, K. Westenfelder, M. Eiber, B. Frisch, N. Navab Preconditioned Intensity-Based Prostate Registration using Statistical Deformation Models IEEE International Symposium on Biomedical Imaging (ISBI), Melbourne, April 2017. (bib)
2015
	O. Zettinig, A. Shah, C. Hennersperger, M. Eiber, C. Kroll, H. Kübler, T. Maurer, F. Milletari, J. Rackerseder, C. Schulte-zu-Berge, E. Storz, B. Frisch, N. Navab Multimodal Image-Guided Prostate Fusion Biopsy based on Automatic Deformable Registration International Journal of Computer Assisted Radiology and Surgery / 6th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Barcelona, June 2015. The original publication is available online at link.springer.com (bib)
	A. Shah, O. Zettinig, E. Storz, T. Maurer, M. Eiber, N. Navab, B. Frisch Challenges in Multimodal Image-guided Targeted Prostate Biopsy Hamlyn Symposium on Medical Robotics, London, UK, June 2015 (bib)
	B. Frisch, E. Storz, O. Zettinig, A. Shah, H. Kübler, N. Navab, HP Wester, M. Schwaiger, M. Eiber, T. Maurer PET/MRI/TRUS image fusion guided prostate biopsy: development of a research platform and initial clinical results Society of Nucler Medicine and Medical Imaging Annual Meeting, Baltimore, USA, 2015 (bib)
	E. Storz, A. Shah, O. Zettinig, M. Eiber, H.-J. Wester, H. Kübler, J. Gschwend, M. Schwaiger, B. Frisch, T. Maurer PSMA-PET/MRI-guided fusion biopsy for the detection of prostate cancer Annual Congress of European Association of Urology (EAU), Madrid, March 2015 (bib)
2014
	A. Shah, O. Zettinig, T. Maurer, C. Precup, C. Schulte-zu-Berge, J. Weiss, B. Frisch, N. Navab An Open Source Multimodal Image-guided Prostate Biopsy Framework 3rd Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging (CLIP), 17th MICCAI, MIT, Boston, USA, September 2014. The original publication is available online at link.springer.com (bib)

Team

Contact Person(s)

M.Sc. Beatrice Demiray

Working Group

M.Sc. Beatrice Demiray

Alumni

Dr. Christoph Hennersperger

Julia Rackerseder

Dr. Oliver Zettinig

Location

Technische Universität München Institut für Informatik / I16 Boltzmannstr. 3 85748 Garching bei München Tel.: +49 89 289-17058 Fax: +49 89 289-17059

Visit our lab at Garching.

Klinikum rechts der Isar der Technischen Universitüt München Ismaninger Str. 22 81675 München IFL Lab - Room: 01.3a-c Tel.: +49 89 4140-6457 Fax: +49 89 4140-6458

Visit our lab at Klinikum rechts der Isar.



internal project page

Please contact Beatrice Demiray for available student projects within this research project.