Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

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Prostate Fusion Biopsy

Prostate Fusion Biopsy

In medical collaboration with:
Poliklinik und Klinik für Urologie, Klinikum Rechts der Isar
Klinik für Nuklearmedizin, Klinikum Rechts der Isar

Scientific Director: Nassir Navab and Christoph Hennersperger

Contact Person(s): Beatrice Demiray

Keywords: Registration / Visualization, Segmentation, Medical Imaging, Computer-Aided Surgery, IFL


Transrectal ultrasound (TRUS) guided biopsy remains the gold standard for diagnosis. However, it suffers from low sensitivity, leading to an elevated rate of false negative results. On the other hand, the recent advent of PET imaging using a novel dedicated radiotracer, Ga-labelled PSMA (Prostate Specific Membrane Antigen), combined with MR provides improved preinterventional identification of suspicious areas. Thus, MRI/TRUS fusion image-guided biopsy has evolved to be the method of choice to circumvent the limitations of TRUS-only biopsy. We propose a multimodal fusion image-guided biopsy framework that combines PET-MRI images with TRUS. Based on open-source software libraries, it is low cost, simple to use and has minimal overhead in clinical workflow. It is ideal as a research platform for the implementation and rapid bench to bedside translation of new image registration and visualization approaches.


O. Zettinig, J. Rackerseder, B. Lentes, T. Maurer, K. Westenfelder, M. Eiber, B. Frisch, N. Navab
Preconditioned Intensity-Based Prostate Registration using Statistical Deformation Models
IEEE International Symposium on Biomedical Imaging (ISBI), Melbourne, April 2017. (bib)
O. Zettinig, A. Shah, C. Hennersperger, M. Eiber, C. Kroll, H. Kübler, T. Maurer, F. Milletari, J. Rackerseder, C. Schulte-zu-Berge, E. Storz, B. Frisch, N. Navab
Multimodal Image-Guided Prostate Fusion Biopsy based on Automatic Deformable Registration
International Journal of Computer Assisted Radiology and Surgery / 6th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Barcelona, June 2015.
The original publication is available online at
A. Shah, O. Zettinig, E. Storz, T. Maurer, M. Eiber, N. Navab, B. Frisch
Challenges in Multimodal Image-guided Targeted Prostate Biopsy
Hamlyn Symposium on Medical Robotics, London, UK, June 2015 (bib)
B. Frisch, E. Storz, O. Zettinig, A. Shah, H. Kübler, N. Navab, HP Wester, M. Schwaiger, M. Eiber, T. Maurer
PET/MRI/TRUS image fusion guided prostate biopsy: development of a research platform and initial clinical results
Society of Nucler Medicine and Medical Imaging Annual Meeting, Baltimore, USA, 2015 (bib)
E. Storz, A. Shah, O. Zettinig, M. Eiber, H.-J. Wester, H. Kübler, J. Gschwend, M. Schwaiger, B. Frisch, T. Maurer
PSMA-PET/MRI-guided fusion biopsy for the detection of prostate cancer
Annual Congress of European Association of Urology (EAU), Madrid, March 2015 (bib)
A. Shah, O. Zettinig, T. Maurer, C. Precup, C. Schulte-zu-Berge, J. Weiss, B. Frisch, N. Navab
An Open Source Multimodal Image-guided Prostate Biopsy Framework
3rd Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging (CLIP), 17th MICCAI, MIT, Boston, USA, September 2014.
The original publication is available online at


Contact Person(s)

Beatrice Demiray
M.Sc. Beatrice Demiray

Working Group

Beatrice Demiray
M.Sc. Beatrice Demiray


Christoph Hennersperger
Dr. Christoph Hennersperger
Julia Rackerseder
Julia Rackerseder
Oliver Zettinig
Dr. Oliver Zettinig


Technische Universität München
Institut für Informatik / I16
Boltzmannstr. 3
85748 Garching bei München

Tel.: +49 89 289-17058
Fax: +49 89 289-17059
Visit our lab at Garching.

Klinikum rechts der Isar
der Technischen Universitüt München
Ismaninger Str. 22
81675 München

IFL Lab - Room: 01.3a-c
Tel.: +49 89 4140-6457
Fax: +49 89 4140-6458
Visit our lab at Klinikum rechts der Isar.

internal project page

Please contact Beatrice Demiray for available student projects within this research project.

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