Univ.-Professor Dr. Michael Friebe Dipl.-Ing., M.Sc. E-mail: Image Guided Surgery / Catheter Technologies Faculty of Electrical Engineering, Institute of Medical Engineering Otto-von-Guericke-Universität Magdeburg http://www.inka-md.de IDTM Ingenieurgesellschaft mbH + FVW Investments http://www.idtmt.de http://www.fvw-investments.com Rudolf-Diesel-Industry-Fellow TUM-IAS (http://www.tum-ias.de) TUM-IAS Building, Room 2.004 Lichtenbergstraße 2 a 85748 Garching Phone +49.89.289.10653 Fax +49.89.289.10699 SKYPE "mfriebe"

Biography

• Born 1964, married, two sons
• Dipl.-Ing. Nachrichtentechnik, Stuttgart; Master of Science - Management, San Francisco; Dr. rer. medic. Medizinphysik, Witten
• 5 years in San Francisco (UCSF / UC RIL / TOSHIBA MRI) as MRI R&D and Project Engineer / Product Manager
• Entrepreneur since 1993 -- founded NEUROMED AG, the largest independent radiology / Imaging services provider in Central Europe
• Started 10 more companies in Germany and other neighboring countries -- all involved with Medical Imaging technologies between 1993 and 2001
• 2001 trade sale of NEUROMED AG to UMS AG
• Started TOMOVATION GmbH in 2003, investment / development and trading company in Medical Imaging (TOMOgraphy + InnoVATION)
• 2008 sale of the company to ALLIANCE Medical, Inc., Warwick UK - Michael left Alliance in 2011 as Managing Director Central Europe
• Since 2003 investment in 7 Medical Technology companies with FVW Investments (www.fvw-investments.com) + m2f investment (www.m2f-investment.com), two early stage investment companies
• Since 2004 2 trade sales and 4 technology licensing arrangements
• Former board member of US publicly traded companies (INTRAOPMEDICAL, Inc.; BIOPHAN, Inc.; Mobile PET Systems, Inc.)
• Currently Vice-Chairman of SURGICEYE GmbH (http://www.surgiceye.com)
• Board member of Eckert&Ziegler BEBIG SA from Senefe, Belgium (http://www.ezag.de)
• Member of the Business Angel Network Germany (BAND) and introduced in the „Business Angel Heaven of Fame“ in 2006
• Germany's Business Angel of the year 2011
• since Oct 2012 Rudolf-Diesel-Industry-Fellow of the Institute for advanced Studies and affiliated Professor at CAMP
• Guest Professor in Healthcare Innovation Generation at KAIST, Daejeong, Korea; QTU Brisbane, Australia
• since 2014 Honorary Professor of Biomedical Engineering at MISR University (http://www.must.edu.eg), Cairo (6th of October City), Egypt
• appointed (Dec. 2014) full Professor of Catheter Technologies and Image Guided Surgeries at the Otto-von-Guericke-University in Magdeburg, Germany (http://www.ovgu.de/friebe and http://www.inka-md.de)

Teaching

• Lecture Medical Imaging Entrepreneurship (2010WiSe)
• Lecture Medical Imaging Entrepreneurship (2011SoSe)
• Lecture Medical Imaging Entrepreneurship (2011WiSe)
• Lecture Medical Technology Entrepreneurship (2012SoSe)
• Lecture Medical Technology Entrepreneurship (2012WiSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2013SoSe)
• Lecture Translational Technology Entrepreneurship (2013SoSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2013WiSe)
• Lecture Translational Technology Entrepreneurship (2013WiSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2014SoSe)
• Lecture Translational Technology Entrepreneurship (2014SoSe)
• Lecture Innovation Generation and Entrepreneurship in the Healthcare Domain (2014WiSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2015SoSe)
• Lecture Innovation Generation and Entrepreneurship in the Healthcare Domain (2015WiSe)
• Lecture Innovation Generation and Entrepreneurship in the Healthcare Domain (2016SoSe)
• Lecture Image Guided Surgeries - From Bench to Bedside and Back (2016SoSe)
• Lecture Innovation Generation in the Healthcare Domain (2017SoSe)
• Lecture Medical Imaging Entrepreneurship (2017WiSe)
• Lecture Innovation Generation in the Healthcare Domain (2018SoSe)
• Lecture Medical Imaging Entrepreneurship (2018WiSe)
• Lecture Innovation Generation in the Healthcare Domain (2019SoSe)
• Lecture Innovation Generation in the Healthcare Domain (2020WiSe)
• Lecture Innovation Generation in the Healthcare Domain (2021SoSe)
• Lecture Innovation Generation in the Healthcare Domain (2021WiSe)

Patents and Patent Applications (German only)

• > 30 PCT, EP, and US applications
• DE102014008734 -- Fernüberwachungssystem für supraleitende Magnetsysteme
• DE102014104529 -- Operationstisch
• DE102014101763 -- Injektionssystem für MRT Anwendungen
• DE102013110375 -- Applikator und Depot für eine radioaktive Strahlenquelle zur Brachytherapie
• DE102013109853 -- Applikator für die Magnetresonanztomographie
• DE102013109486 -- Navigationsaufsatz
• DE102013001989 -- Handheld Hybrid-, Diagnose- und Niederenergiebestrahlungssystem
• DE102012008765 -- Hybrides Bildgebungssystem für intraoperative und diagnostische Anwendungen
• DE102012000769 -- System für die geriatrische Notfall- und Vitalparameterkommunikation
• DE102011018604 -- Medikamenteninfusor für die Anwendung in stark magnetischen Feldern
• DE102008057255 -- Kathetereinrichtung
• DE102008019304 -- Kathetereinrichtung für perkutane Eingriffe
• DE112007001370 -- Verfahren und System zur Versorgung eines abgeschirmten medizinischen Systems
• DE102007021844 -- Daten-Energie-Hybridleitung für die Anwendung in der MRT
• DE102007016674 -- Katheter bzw. Führungsdraht mit positivem und negativem Kontrast ...
• DE102007013535 -- Patientengrid mit dedizierten Markern zur Bestimmung der Ortskoordinaten in einem MRT
• DE102007003609 -- Infusionschlauch für eine Pumpvorrichtung und Pumpvorrichtung zur Anwendung in der MRT
• DE102006024919 -- Verfahren und Messgerät zur Erfassung von Störfeldern an einem Installationsort für MRT
• DE102006006952 -- MRT-System
• DE102005052226 -- Stent zum Einführen in menschliche Körperhöhle, insbesondere in ...
• DE102005046077 -- Magnetresonanztomograph und Verfahren zur Anzeige einer Einstichstelle ...
• DE000004317028 -- Verfahren zur Akquisition und Auswertung von Daten in einem Kernspin-Tomographen
• DE000004216983 -- Einrichtung für die minimal invasive Therapie und Mikrotherapie

Publications

2015
	P. Matthies, B. Frisch, J. Vogel, T. Lasser, M. Friebe, N. Navab Inside-Out Tracking for Flexible Hand-held Nuclear Tomographic Imaging IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
2014
	E. Nasanova, M. Durst, C. Gringen, E. Farreif, M. Friebe, A. Haase, M. Schwaiger, R. Schulte Compensating for Metabolic Dynamics in 13C Chemical Shift Separation Presentation ISMRM/ESMRMB 2014, Toulouse (bib)
	E. Nasanova, M. Durst, C. Gringen, E. Farreif, M. Friebe, A. Haase, M. Schwaiger, R. Schulte Reconstruction of Carbon-13 Metabolic MR Images Using Constrained Optimization Presentation ISMRM/ESMRMB 2014, Toulouse (bib)
	M. Friebe, A. Katouzian, P. Matthies, S. O. Cho Miniaturized cold emission low energy X-ray tubes for MRI guided intraoperative radiation therapy - A technical feasibility study Poster presentation and book of abstracts, IGIC 2014, Magdeburg (bib)
	M. Friebe, H.-W. Henke, P. Matthies, A. Katouzian, G. Krombach MRI biopsy with semi-automated biopsy needle in Slicer 3D environment Poster presentation and book of abstracts, IGIC 2014, Magdeburg (bib)
	M. Friebe, P. Matthies, S. O. Cho Low Energy Radiation Therapy - feasibility of using a field emission miniature X-ray tube for intraoperative treatments under MRI guidance Oral presentation and book of abstracts, CARS 2014 annual meeting, Fukuoka (bib)
2013
	P. Matthies, S. O. Cho, M. Friebe Integration of a low energy radiation source in MRI environment for intraoperative applications - a Feasibility Evaluation 25th International Conference of the International Society for Medical Innovation and Technology, iSMIT 2013 in Baden-Baden, Germany, September 05-07, 2013 (bib)
	M. Friebe, J. Traub Translational research with students - first experience from a new lecture format in image guided surgeries - innovation creation?! 25th International Conference of the International Society for Medical Innovation and Technology, iSMIT 2013 in Baden-Baden, Germany, September 05-07, 2013 (bib)
	P. Matthies, A. Okur, T. Wendler, N. Navab, M. Friebe Combination of intra-operative freehand SPECT imaging with MR images for guidance and navigation IEEE Engineering in Medicine and Biology (EMBC), Osaka, Japan, July 2013. (bib)
	S. Bock, S. Dahl, M. Schneider, A. Hartmann, M. Kramer, H.-W. Henke, M. Friebe, G. Krombach Entwicklung eines MR-kompatiblen Kathetersystems zur bildgesteuerten intramyokardialen Injektion Poster Presentation DRG 2013, Hamburg (bib)
2012
	M. Friebe, T. Wendler, J. Traub, B. Tombach, N. Navab 3D handheld SPECT combined with serially acquired MRI reference images - feasibility study for intraoperative applications Proceedings of the 9th Interventional MRI Symposium Boston, September 2012 (bib)
	M. Friebe, H. Adleff, T. Guschauwski, B. Tombach OSMOFUSOR - osmotically driven fully MRI compatible infusor / drug applicator Proceedings of the 9th Interventional MRI Symposium Boston, September 2012 (bib)

additional Publications (selected)

• Keyhole Sequence with Rotational Update as a means of fast, high Quality LOW-FIELD Interventional MR Imaging; M. Friebe, M. Busch, D. Grönemeyer, R. Seibel, S. Hellwig; SMRM Proceedings Volume 1, 1993: 161
• High-Field non-invasive in-vivo thermometry sequence using spin-echo keyhole techniques; M. Friebe, M. Busch, M. Schaldach, M. Koch, D. Grönemeyer; RSNA Chicago Scientific Program 1993:271
• 3 dimensional keyhole sequence with rotational k-space updating for fast, high quality low-field MR imaging; M. Busch, M. Friebe, S. Hellwig, D. Grönemeyer, R. Seibel; RSNA Chicago Scientific Program 1993:348
• Keyhole Sequence in two Dimensions for high speed fluoroscopic imaging (PHREAK); M. Busch, M. Friebe, S. Hellwig, D. Grönemeyer, R. Seibel; Journal Mag. Res. Imag. 1994 Suppl. 4(P) :38
• Low back pain treatment by Interventional MRI-Guidance; DHW Groenemeyer, RMM Seibel, G. Schmid, M. Friebe, M. Deli, M. Busch; Journal Mag. Res. Imag. 1994 Suppl. 4(P) :39
• Interventional MRI-Guidance, Competition for CT in the Field of Micro-Therapy K-space manipulations and reduced acquisition schemes for Low-Field IVMRI sequences; M. Busch, M. Friebe, S. Hellwig, H. Lerchner, D. Grönemeyer. R. Seibel; SMRM Proceedings Volume 1, 1994:789
• Low-Field NMR Thermometry with diffusion sensitized keyhole and weighted K-space sequencing schemes; M. Friebe, M. Busch, M. Schaldach, M. Koch, D. Grönemeyer, R. Seibel; SMRM Proceedings Volume 1, 1994:1575
• System design, physical parameters, user environment – requirements for interventional MRI; M. Friebe, M. Busch, S. Hellwig, M. Deli, D. Grönemeyer, R. Seibel; European Radiology 1995 Suppl. (5):234
• Future of advanced guidance techniques by interventional CT and MRI; Grönemeyer D, Seibel RM, Melzer A, Schmidt A, Deli M, Friebe M, Busch M; Minim Invasive Ther Allied Technol 1995; 4:251-9.
• MRI imaging of substrates in resonant stents; E. Immel, G. Lorenz, M. Friebe, A. Melzer; ESMRMB 2005, Basel, abstract 446
• Visualization of intraluminal tissue in inductively coupled MR resonant stents, vena cava filters and porcine heart valve stents; E. Immel, J. Spillner, A. Melzer, G. Schaefers, T. Bertsch, G. Lorenz, M. Friebe; Minimal Invasive Therapy & Allied Technologies Volume 14 Number 4-5 2005, #059, p311
• Status QUO: Standards for Mr Safety Testing and Labeling of Devices; G. Schaefers, M. Friebe, A. Melzer; Europac 01/2005; 7. DOI:10.1016/j.eupc.2005.08.111
• Development of a novel, balloon expandable endovascular stent design with an integrated resonance circuit for active visualization in MRI; Christoph K. Naber, Frank Breuckmann, Erwin Immel, Stephanie Aker, Gernot M. Kaiser, Michael Friebe, Andreas Melzer, Raimund Erbel, Harald H. Quick; World Congress of Cardiology 2006, Barcelona
• Improved design of a resonant balloon expandable alloy stent for MR visualization with inductive signal coupling; E. Immel, C. K. Naber, H. H. Quick, F. Breuckmann, S. Aker, G. M. Kaiser, D. Baumgart, C. Thonack, R. Erbel, M. Friebe, F. Götz, A. Melzer; Abstract and EPOS presentation ESMRMB 2006, Warsaw
• MRT-gesteuerte perkutane intramyokardiale Injektion von Kontrastmittelgemisch nach Myokardinfarkt: Katheterentwicklung und experimentelle Ergebnisse ; G. Krombach, C. Hohl, S. Kinzel, J. Pfeffer, M. Friebe, RW Günther, A. Bücker; Abstract and presentation, Experimentelle Radiologie 2006, Kiel
• MR guided angioplasty of peripheral arteries: delivery of substances into the vessel wall; G. Krombach, M. Wehner, A. Perez-Bouza, S. Kinzel, M. Friebe, L. Kaimann, T. Plum, D. Schibur, R. Guenther, C. Hohl; Abstract and presentation ISMRM 2007, Berlin
• Development of a catheter for MRI-guided intramyocardial injection; G. Krombach, A. Buecker, J. Pfeffer, C. Hohl, J. Temur, M. Friebe, S. Kinzel, R. Guenther; Abstract and presentation ISMRM 2007, Berlin
• PSPICE Simulation of the MRI resonance behavior of intravascular implants; D. Sachtler, M. Friebe, U. Jorczyk; Abstract and presentation DRG 2007, Berlin
• Simulation des elektrischen Verhaltens MR-kompatibler Implantate unter Verwendung von PSpice; D Sachtler, M Friebe, U Jorczyk; ROFO-FORTSCHR RONTGENSTRAHL 01/2007; 179. DOI:10.1055/s-2007-977002
• Evaluation and comparison of water and carbon dioxide for colonic distension at dark-lumen MR colonography; C.U. Herborn, C. Gocke, M. Joeckel, M. Friebe, M. Goye; Abstract and presentation ECR 2008, Vienna
• Intraoperative fMRI - cortex stimulator hardware and passive paradigm - StimuLink; T. Gasser, M. Friebe; Abstract and presentation ESMRMB 2008 Valencia
• Autonomous navigation assistant for MRI guided interventions; M. Friebe, D. Sachtler, S. Hellwig, G. Sakas, U. Jorczyck, M. Schlüter; Abstract and presentation ESMRMB 2008 Valencia
• Magnetic resonance-guided angioplasty with delivery of contrast-media doped solutions to the vessel wall: an experimental study in swine; Krombach GA, Wehner M, Perez-Bouza A, Kaimann L, Kinzel S, Plum T, Schibur D, Friebe M, Günther RW, Hohl C (2008). Invest Radiol.43:530-7 (IF 5,289)
• Interventionelle MRT bei 3 Tesla: Durchführbarkeit endovaskulärer Interventionen; GA Krombach, S Schmitz, M Friebe, T Plum, M Distelmaier, M Hellmann, RW Günther, C Hohl; ROFO-FORTSCHR RONTGENSTRAHL 01/2008; 180. DOI:10.1055/s-2008-1073817
• Evaluation of an Interactive Breath-Hold Control System in CT-Guided Lung Biops; F. Schoth, C. Plumhans, N. Kraemer, A. Mahnken, M. Friebe, R. Günther, G. Krombach; RöFo-08-2009-1174-IR.R1
• MR guided angioplasty of peripheral arteries at 3T for delivery of drug containing solutions to the vessel wall; G.A. Krombach, A. Perez-Bouza, M. Friebe, R.W. Günther, C. Hohl; ECR 2010, B-600, S. 356
• Registration Free SPECT and Ultrasound Imaging; S. Wiesner, P. Dressel, M. Friebe, M. Freesmeyer, N. Navab, T. Wendler, J. Traub; Abstract and presentation SMIT 2011 Tel Aviv
• Clinical Potential of DECLIPSE SPECT providing intraoperative 3D imaging for image guided tumor surgery; S. Wiesner, M. Friebe, N. Navab, T. Wendler, J. Traub; Abstract and presentation SMIT 2011 Tel Aviv
• Metal and electronic free full MRI compatible medical infusor; M. Friebe, H.Adleff; Abstract and presentation ESMRMB 2011 Leipzig
• Medical Imaging Entrepreneurship - a dedicated lecture to stimulate and excite science students; Friebe M., Navab N.; SMIT 2011
• 3D handheld SPECT combined with serially acquired MRI reference images - feasibility study for intraoperative applications; M. Friebe, T. Wendler, J. Traub, B. Tombach, N. Navab; 9th interventional MRI symposium Boston
• OSMOFUSOR - osmotically driven fully MRI compatible infusor / drug applicator; M. Friebe, H. Adleff, T. Guschauwski, B. Tombach; 9th interventional MRI symposium Boston
• Development of a passive-trackable catheter system to perform MR-guided minimal invasive intramyocardial injections – in vivo and consecutive ex vivo study; Bock S., Dahl S., Tacke S., Schneider M., Hartmann A., Kramer M., Henke HW, Friebe M., Krombach G.; abstract and presentation 10th Interventional MRI Symposium 2014, Leipzig