AsliOkur

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

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Dr. Aslı Okur Kuru

Picture of me Dr. rer. nat.
Aslı Okur Kuru


currently at
Arthrex GmbH
Erwin-Hielscher-Str. 9
81249 München, Germany


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Dissertation

Challenges in Deployment of Advanced Radioguided Surgery Solutions

Abstract:

Radioguided surgery is a well-established clinical discipline. However, the devices or systems are not necessarily optimized for the particular needs of the target clinical application. This thesis addresses several challenges associated with the deployment of new technologies or concepts for radioguided surgery in different clinical scenarios on the concrete example of Freehand SPECT, a novel 3D nuclear imaging and navigation system. This includes the analysis of the clinical workflow, definition of the supporting functions of the technology and its modification towards integrated applications.

Download: http://mediatum.ub.tum.de?id=1485240

Research Interests

  • Radioguided Surgery
  • Nuclear Imaging
  • Surgical Workflow
  • Intraoperative Usability
  • Medical Augmented Reality

Education

  • 1996 - 2004
    Deutsche Schule Istanbul - Istanbul, Turkey

Teaching

Student Projects

Publications

2017
A. Okur, R. Stauder, H. Feußner, N. Navab
Quantitative Characterization of Components of Computer Assisted Interventions
arXiv:1702.00582 [cs.OH], 2017 (bib)
2015
B. Frisch, T. Maurer, A. Okur, T. Weineisen, , H. Kübler, N. Navab, HP Wester, M. Schwaiger, M. Eiber
Freehand SPECT for 111In-PSMA-I&T radioguided lymphadenectomy in prostate cancer patients
Society of Nucler Medicine and Medical Imaging Annual Meeting, Baltimore, USA, 2015 (bib)
T. Maurer, T. Weineisen, HP Wester, , A. Okur, G. Weirich, H. Kübler, M. Schwaiger, J. Gschwend, B. Frisch, M. Eiber
PSMA-radioguided surgery: Introducing molecular surgery in patients with recurrent prostate cancer
2015 Annual Meeting of the American Urological Association, New Orleans, USA, 2015 (bib)
T. Maurer, G. Weirich, , T. Weineisen, B. Frisch, A. Okur, N. Navab, M. Schwaiger, HP Wester, J. Gschwend, M. Eiber
PSMA-radioguided surgery for metastatic lymph nodes in prostate cancer
European Urology, in press, available online 6 May 2015 (bib)
T. Maurer, T. Weineisen, HP Wester, , A. Okur, G. Weirich, H. Kübler, M. Schwaiger, J. Gschwend, B. Frisch, M. Eiber
Introduction of PSMA-radioguided surgery in patients with recurrent prostate cancer: taking salvage lymphadenectomy to the next level?
Annual Congress of European Association of Urology (EAU), Madrid, March 2015 (bib)
C. Vetter, T. Lasser, A. Okur, N. Navab
1D-3D Registration for Intra-operative Nuclear Imaging in Radio-guided Surgery
IEEE Transactions on Medical Imaging 34(2):608-617, 2015 (bib)
2014
T. Maurer, G. Weirich, T. Weineisen, HP Wester, B. Frisch, A. Okur, H. Kübler, M. Schwaiger, J. Gschwend, M. Eiber
Initial experience with PSMA-radioguided surgery in prostate cancer patients
3rd Meeting of the EAU Section of Urological Imaging, Lisbon, Portugal, 2014 (bib)
B. Frisch, M. Eiber, J. Gardiazabal, P. Matthies, T. Maurer, A. Okur, T. Lasser, N. Navab
Challenges for Intra-Operative SPECT
IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
A. Okur, C. Hennersperger, J.B. Runyan, J. Gardiazabal, M. Keicher, S. Paepke, T. Wendler, N. Navab
fhSPECT-US Guided Needle Biopsy of Sentinel Lymph Nodes in the Axilla: Is it Feasible?
Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, Lecture Notes in Computer Science Volume 8673, 2014, pp 577-584 (bib)
J. Gardiazabal, M. Esposito, P. Matthies, A. Okur, J. Vogel, S. Kraft, B. Frisch, T. Lasser, N. Navab
Towards personalized interventional SPECT-CT imaging
Proceedings of the 17th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Boston, USA, September 2014 (bib)
I. Einspieler, A.R. Novotny, A. Okur, M. Essler, M. E. Martignoni
First Experience With Image-guided Resection of Paraganglioma
Clinical Nuclear Medicine, Volume 39, Issue:8, August 2014. (bib)
R. Stauder, A. Okur, N. Navab
Detecting and Analyzing the Surgical Workflow to Aid Human and Robotic Scrub Nurses
The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib)
A. Okur, R. Voigt, R. Stauder, N. Navab
Investigation of performance log files of freehand SPECT acquisitions for usage characteristics and surgical phase determination
The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib)
P. Matthies, J. Gardiazabal, A. Okur, T. Lasser, N. Navab
Accuracy evaluation of interventional nuclear tomographic reconstruction using mini gamma cameras
The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib)
R. Stauder, A. Okur, L. Peter, A. Schneider, M. Kranzfelder, H. Feußner, N. Navab
Random Forests for Phase Detection in Surgical Workflow Analysis
The 5th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Fukuoka, Japan, June 2014 (bib)
P. Matthies, J. Gardiazabal, A. Okur, J. Vogel, T. Lasser, N. Navab
Mini Gamma Cameras for Intra-operative Nuclear Tomographic Reconstruction
Medical Image Analysis 18(8):1329-1336, 2014 (bib)
A. Okur, C. Gerngross, A. Schnelzer, A. Ehlerding, M. Keicher, S. Wiesner, S. Paepke, K. Scheidhauer, T. Wendler
First experience with fused ultrasound / freehand SPECT system for hybrid lymphatic mapping in breast cancer patients
52. Jahrestagung der Deutschen Gesellschaft fuer Nuklearmedizin, Hannover, Germany, Mar. 26 - 29, 2014. (bib)
A.L. Mihaljevic, A. Rieger, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring innovative freehand SPECT to the operating room: First experiences with sentinel lymph node biopsy in malignant melanoma
European Journal of Surgical Oncology (EJSO), Volume 40, Issue 1, January 2014. (bib)
2013
P. Matthies, K. Sharma, A. Okur, J. Gardiazabal, J. Vogel, T. Lasser, N. Navab
First use of mini gamma cameras for intra-operative robotic SPECT reconstruction
Proceedings of the 16th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nagoya, Japan, September 2013 (bib)
P. Matthies, A. Okur, T. Wendler, N. Navab, M. Friebe
Combination of intra-operative freehand SPECT imaging with MR images for guidance and navigation
IEEE Engineering in Medicine and Biology (EMBC), Osaka, Japan, July 2013. (bib)
J. Gardiazabal, T. Reichl, A. Okur, T. Lasser, N. Navab
First flexible robotic intra-operative nuclear imaging for image-guided surgery
Information Processing in Computer Assisted Interventions (IPCAI), Heidelberg, Germany, June 26, 2013 (bib)
C. Bluemel, A. Schnelzer, A. Okur, A. Ehlerding, S. Paepke, K. Scheidhauer, M. Kiechle
Freehand SPECT for image-guided sentinel lymph node biopsy in breast cancer
European Journal of Nuclear Medicine and Molecular Imaging.
The original publication is available online at www.springerlink.com
(bib)
A. Okur, D. I. Shakir, P. Matthies, A. Hartl, M. Essler, S. I. Ziegler, T. Lasser, N. Navab
Freehand Tomographic Nuclear Imaging Using Tracked High-Energy Gamma Probes
Bildverarbeitung für die Medizin 2013 (BVM), Heidelberg, Germany, March 2013.
The original publication is available online at www.springerlink.com
(bib)
2012
A. Schnelzer, A. Ehlerding, C. Bluemel, A. Okur, K. Scheidhauer, S. Paepke, M. Kiechle
Showcase of Intraoperative 3D Imaging of the Sentinel Lymph Node in a Breast Cancer Patient using the New Freehand SPECT Technology
Breast Care 2012;7:484-486 (bib)
D. I. Shakir, A. Okur, A. Hartl, P. Matthies, M. Essler, S. I. Ziegler, T. Lasser, N. Navab
Towards Intra-operative PET for Head and Neck Cancer: Lymph Node Localization Using High-energy Probes
Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nice, France, October 2012 (bib)
A. Bigdelou, R. Stauder, T. Benz, A. Okur, T. Blum, R. Ghotbi, N. Navab
HCI Design in the OR: A Gesturing Case-study
MICCAI 2012 Workshop on Modeling and Monitoring of Computer Assisted Interventions (M2CAI), Nice, France, October 2012 (bib)
I. Einspieler, A. Okur, A.R. Novotny, M. E. Martignoni, K. Scheidhauer
Case Report - Image-guided Resection of Paraganglioma
32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib)
A. Rieger, J. Saeckl, R. Hein, A. Okur, T. Wendler, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring Innovative Freehand SPECT to the Operating Room - First Experiences with Sentinel Lymphonodectomy in Malignant Melanoma
32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib)
N. Navab, T. Blum, L. Wang, A. Okur, T. Wendler
First Deployments of Augmented Reality in Operating Rooms
IEEE Computer, Volume 45, Issue 7, pp. 48-55 (bib)
A. Bigdelou, A. Okur, M.-E. Hoffmann, B. Azizi, N. Navab
Towards systematic usability evaluations for the OR: an introduction to OR-Use framework
Information Processing in Computer Assisted Interventions (IPCAI), Pisa, Italy, June 27, 2012 (bib)
C. Bluemel, A. Schnelzer, A. Rieger, A. Ehlerding, A. Okur, C. Gerngross, M. E. Martignoni, K. Scheidhauer, M. Schwaiger
3D navigated (radio-guided) sentinel lymph node biopsy using freehand SPECT : final evaluation of Munich's pilot experience in the operating room
50. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Messe Bremen, Germany, April 2012 (bib)
2011
A. Okur, A. Ahmadi, A. Bigdelou, T. Wendler, N. Navab
MR in OR: First analysis of AR/VR visualization in 100 intra-operative Freehand SPECT acquisitions
The 10th IEEE and ACM International Symposium on Mixed and Augmented Reality (ISMAR), Basel, Switzerland, Oct. 26 - 29, 2011. (bib)
C. Bluemel, A. Schnelzer, A. Ehlerding, A. Okur, K. Scheidhauer, M. Kiechle, M. Schwaiger
Evaluation of freehand SPECT in sentinel lymph node biopsy of breast cancer
Proceedings of the Annual Congress of the European Association of Nuclear Medicine (EANM), Birmingham, UK, October 2011 (bib)
A. Rieger, J. Saeckl, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Wendler, J. Traub, H. Friess, M. E. Martignoni
First Experiences with Navigated Radio-Guided Surgery Using Freehand SPECT
Case Reports in Oncology, August 2011 (bib)
A. Okur, C. Bluemel, A. Ehlerding, K. Scheidhauer, A. Schnelzer
Meme kanseri cerrahisinde freehandSPECT ile ilk tecrube: Aksiller sentinel lenf nodu biyopsisinde uc boyutlu navigasyon ve kalite guvencesi
XI. Ulusal Meme Hastaliklari Kongresi, Antalya, Turkey, Oct. 5 - 9, 2011. (bib)
C. Lapa, J. Saeckl, A. Rieger, C. Bluemel, A. Okur, T. Wendler, M. E. Martignoni, K. Scheidhauer
Investigating added value of freehand SPECT in sentinel node biopsy of melanomas
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib)
C. Bluemel, A. Ehlerding, C. Lapa, A. Okur, T. Wendler, A. Schnelzer, K. Scheidhauer
Improvements in sentinel node biopsy of breast cancer using freehand SPECT
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib)
2010
M. C. Kreissl, A. Okur, T. Chen, A. Bartel, T. Wendler, K. Scheidhauer
Pilot study of freehand SPECT for lymphatic mapping in melanoma in upper body
Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib)

Research

Intra-operative Human Computer Interaction and Usability Evaluations

Intra-operative Human Computer Interaction and Usability Evaluations

Computerized medical systems play a vital role in the operating room, yet surgeons often face challenges when interacting with these systems during surgery. In this project we are aiming at analyzing and understanding the Operating Room specific aspects which affect the end user experience. Beside operating room specific usability evaluation approaches in this project we also try to improve the preliminary intra-operative user interaction methodologies.
Advanced Robotics for Multi-Modal Interventional Imaging (RoBildOR)

Advanced Robotics for Multi-Modal Interventional Imaging (RoBildOR)

This project aims at developing advanced methods for robotic image acquisitions, enabling more flexible, patient- and process-specific functional and anatomical imaging with the operating theater. Using robotic manipulations, co-registered and dynamic imaging can be provided to the surgeon, allowing for optimal implementation of preoperative planning. In particular, this projects is the first one developing concepts for intraoperative SPECT-CT, and introduces intraoperative robotic Ultrasound imaging based on CT trajectory planning, enabling registration with angiographic data. With distinguished partners from Bavarian industry, this project has a fundamental contribution in developing safe, reliable, flexible, and multi-modal imaging technologies for the operating room of the future.
Freehand SPECT for Sentinel Lymph Node Localization

Freehand SPECT for Sentinel Lymph Node Localization

Nuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging.
In-PSMA Radioguided Surgery

In-PSMA Radioguided Surgery

With the advent of 68Ga-HBED-PSMA PET hybrid imaging techniques, even small and atypical localized metastatic lesions of prostate cancer can be visualized. However, these lesions might not be easy to localize intraoperatively. The aim of project is to evaluate intraoperative detection of metastatic lesions using a gamma probe and freehand SPECT after injection of radioactive-labelled PSMA-ligands in correlation with postoperative histological findings.


UsersForm
Title: Dr.
Circumference of your head (in cm):  
Firstname: Aslı
Middlename:  
Lastname: Okur Kuru
Picture: asli-thumbnail.JPG
Birthday: 1985/05/09
Nationality: Germany
Languages: English, German, Turkish
Groups: Surgical Workflow, Reconstruction, Medical Imaging, Molecular Imaging, Computer-Aided Surgery, Medical Augmented Reality, IFL
Expertise: Surgical Workflow, Medical Imaging, Molecular Imaging, Computer-Aided Surgery, Medical Augmented Reality
Position: Scientific Staff
Status: Alumni
Emailbefore: asli.okur
Emailafter: tum.de
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Alumniactivity: Arthrex GmbH
Defensedate: 4 December 2019
Thesistitle: Challenges in Deployment of Advanced Radioguided Surgery Solutions
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