Interdiziplinäres Projekt (IDP) Mathematik oder Medizin: Workflow analysis of beta-probe guided surgery

Advisor: Nassir Navab
Supervision by: Joerg Traub, Tobias Sielhorst and Thomas Wendler

Abstract

In minimally invasive tumor resection, the desirable goal is to perform a minimal but complete removal of cancerous cells. In the last decades interventional nuclear medicine probes supported the detection of remaining tumor cells. However, scanning the patient with an intraoperative probe and applying the treatment are not done simultaneously. In the past we extended the one dimensional signal of a nuclear probe to a four dimensional signal including the spatial information of the distal end of the probe (current status). This signal can be then used to guide the surgeon in the resection of residual tissue and thus increase its spatial accuracy while allowing minimal impact on the patient. The next step is to prepare clinical experiments and integrate the solution into the clinical workflow. The student in charge of this project will contribute in that step by analysing the clinical workflow of beta-probe-guided surgery according with the perpective of our group (CAMP research on workflow).

Task

Workflow analysis of beta-probe-assisted cancer surgeries (for more details see abstract above or live demo at Klinikum rechts der Isar).

Requirements

• Basic knowledge: Statistics and ad-hoc software.
• Recommendable knowledge: C++, Matlab.
• Interest in medical technology (You will work most of the time at Klinikum rechts der Isar at NaNuLab).

What you get out of it

• Experience with different fields of research in computer science: Augmented Reality, Computer Graphics, Visualization, Software Engineering
• Knowledge about clinical/surgical workflow, medical technology
• Research on an exciting topic within an interdisciplinary and international team
• Finally the DHP grade in your minor

Literature

	J. Vogel, T. Reichl, J. Gardiazabal, N. Navab, T. Lasser Optimization of Acquisition Geometry for Intra-operative Tomographic Imaging Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nice, France, October 2012 (bib)
	D. I. Shakir, A. Hartl, F. R. Schneider, J. Pulko, S. I. Ziegler, N. Navab, T. Lasser Two new ad-hoc models of detection physics and their evaluation for navigated beta probe surface imaging Proceedings of SPIE Visualization, Image-Guided Procedures, and Modeling Conference, San Diego, CA, USA, February 2012 (bib)
	D. I. Shakir, T. Lasser, A. Drzezga, S. I. Ziegler, N. Navab Evaluation of Navigated Beta-Probe Surface Imaging on a Realistic 3D Phantom Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), Valencia, Spain, October 2011 (bib)
	D. I. Shakir, A. Hartl, N. Navab, S. I. Ziegler Evaluation of an ad hoc model of detection physics for navigated beta-probe surface imaging Proceedings of SPIE Visualization, Image-Guided Procedures, and Modeling Conference, Lake Buena Vista (Orlando Area), FL, USA, February 2011 (bib)
	D. I. Shakir, N. Navab, S. I. Ziegler Acquisition Model for Iterative Reconstruction of Navigated Beta-Probe Surface Images Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), Knoxville, TN, USA, November 2010 (bib)
	D. I. Shakir, J. Bieniarz, S. Pirsig, T. Wendler, N. Navab, S. I. Ziegler A first study on biological feasibility of intraoperative control of tumor resection borders with navigated beta-probe surface imaging Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, UT, USA, June 2010 (bib)
	C. Özgür, J. Bieniarz, T. Lasser, S. I. Ziegler, N. Navab, T. Wendler Phenomenological Models for intraoperative Positron Emission Surface Imaging using Handheld Probes Proceedings of World Congress in Medical Physics and Biomedical Engineering (WC 2009), Munich, Germany, September 2009 (bib)
	T. Wendler, A. Hartl, T. Lasser, J. Traub, S. I. Ziegler, N. Navab Tracking-based statistical correction for radio-guided cancer surgery Proceedings of World Molecular Imaging Congress (WMIC 2008), Nice, France, September 2008 (bib)
	A. Hartl, T. Wendler, J. Traub, T. Lasser, S. I. Ziegler, N. Navab Confident radioactivity surface reconstruction for control of resection borders Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib)
	N. Navab, J. Traub, A. K. Buck, S. I. Ziegler, T. Wendler Navigated nuclear probes for intra-operative functional imaging Proceedings of 5th IEEE International Symposium on Biomedical Imaging (ISBI 2008), Paris, France, May 14 - 17 2008, pp. 1395-1398 (bib)
	N. Navab, J. Traub, T. Sielhorst, M. Feuerstein, C. Bichlmeier Action- and Workflow-Driven Augmented Reality for Computer-Aided Medical Procedures IEEE Computer Graphics and Applications, vol. 27, no. 5, pp. 10-14, Sept/Oct, 2007 (bib)
	T. Wendler, J. Traub, A. Hartl, T. Lasser, M. Burian, A. K. Buck, F. Daghighian, M. Schwaiger, S. I. Ziegler, N. Navab Adding navigation to radio-guided surgery: new possibilities, new problems, new solutions Proceedings of Russian Bavarian Conference on Biomedical Engineering (RBC Biomed 2007), Erlangen, Germany, July 2-3, 2007, pp. 96-100 (bib)
	T. Wendler, J. Traub, S. I. Ziegler, N. Navab Validation of navigated beta-probe imaging with PET/CT-generated activity surfaces. New approach in radio-guided resection for FDG-positive tumors Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2007), Washington D.C., USA, June 2007; Meeting Abstracts 48: 46P-b. (bib)
	O. Kishenkov, T. Wendler, J. Traub, S. I. Ziegler, N. Navab Method for projecting functional 3D information onto anatomic surfaces: Accuracy improvement for navigated 3D beta-probes Proceedings of Bildverarbeitung fuer die Medizin (BVM 2007), Munich, Germany, March 2007, pp.66-70 (bib)
	T. Wendler, J. Traub, S. I. Ziegler, N. Navab Navigated three dimensional beta probe for optimal cancer resection Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 1-6 2006, LNCS 4190 (1), pp. 565-569 (bib)
	R. Stauder, D. Ostler, T. Vogel, D. Wilhelm, S. Koller, M. Kranzfelder, N. Navab Surgical data processing for smart intraoperative assistance systems Innovative Surgical Sciences, 2(3), 145-152, 2017 (bib)
	R. Stauder, E. Kayis, N. Navab Learning-based Surgical Workflow Detection from Intra-Operative Signals arXiv:1706.00587 [cs.LG], 2017 (bib)
	A. Okur, R. Stauder, H. Feußner, N. Navab Quantitative Characterization of Components of Computer Assisted Interventions arXiv:1702.00582 [cs.OH], 2017 (bib)
	R. Stauder, D. Ostler, M. Kranzfelder, S. Koller, H. Feußner, N. Navab The TUM LapChole dataset for the M2CAI 2016 workflow challenge arXiv:1610.09278 [cs.CV], 2016 (bib)
	R. DiPietro?, R. Stauder, E. Kayis, A. Schneider, M. Kranzfelder, H. Feußner, G. D. Hager, N. Navab Automated Surgical-Phase Recognition Using Rapidly-Deployable Sensors MICCAI Workshop on Modeling and Monitoring of Computer Assisted Interventions (M2CAI), Munich, Germany, October 2015 (bib)
	R. Stauder, A. Okur, N. Navab Detecting and Analyzing the Surgical Workflow to Aid Human and Robotic Scrub Nurses The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib)
	R. Stauder, A. Okur, L. Peter, A. Schneider, M. Kranzfelder, H. Feußner, N. Navab Random Forests for Phase Detection in Surgical Workflow Analysis The 5th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Fukuoka, Japan, June 2014 (bib)
	R. Stauder, V. Belagiannis, L. Schwarz, A. Bigdelou, E. Soehngen, S. Ilic, N. Navab A User-Centered and Workflow-Aware Unified Display for the Operating Room MICCAI Workshop on Modeling and Monitoring of Computer Assisted Interventions (M2CAI), Nice, France, October 2012 (bib)
	N. Padoy, T. Blum, A. Ahmadi, H. Feußner, M.O. Berger, N. Navab Statistical Modeling and Recognition of Surgical Workflow Medical Image Analysis (2010), Volume 16, Issue 3, April 2012 (published online December 2010), pp. 632-641. The original publication is available online at www.elsevier.com. (bib)
	T. Blum, H. Feußner, N. Navab Modeling and Segmentation of Surgical Workflow from Laparoscopic Video Medical Image Computing and Computer-Assisted Intervention (MICCAI 2010), Beijing, China, September 2010 (bib)
	T. Blum, N. Navab, H. Feußner Methods for Automatic Statistical Modeling of Surgical Workflow 7th International Conference on Methods and Techniques in Behavioral Research (Measuring Behavior 2010), Eindhoven, The Netherlands, August 2010 (bib)
	A. Ahmadi, F. Pisana, E. DeMomi?, N. Navab, G. Ferrigno User friendly graphical user interface for workflow management during navigated robotic-assisted keyhole neurosurgery Computer Assisted Radiology (CARS), 24th International Congress and Exhibition, Geneva, CH, June 2010 (bib)
	N. Padoy, D. Mateus, D. Weinland, M.O. Berger, N. Navab Workflow Monitoring based on 3D Motion Features ICCV Workshop on Video-oriented Object and Event Classification, Kyoto, Japan, September 2009 (IBM Best Paper Award) (bib)
	A. Ahmadi, N. Padoy, K. Rybachuk, H. Feußner, S.M. Heining, N. Navab Motif Discovery in OR Sensor Data with Application to Surgical Workflow Analysis and Activity Detection MICCAI Workshop on Modeling and Monitoring of Computer Assisted Interventions (M2CAI), London, UK, September 2009 (bib)
	A. Ahmadi, T. Klein, N. Navab Advanced Planning and Ultrasound Guidance for Keyhole Neurosurgery in ROBOCAST Russian Bavarian Conference (RBC), Munich, GER, July 2009 (bib)
	A. Ahmadi, T. Klein, N. Navab, R. Roth, R.R. Shamir, L. Joskowicz, E. DeMomi?, G. Ferrigno, L. Antiga, R.I. Foroni Advanced Planning and Intra-operative Validation for Robot-Assisted Keyhole Neurosurgery In ROBOCAST International Conference on Advanced Robotics (ICAR), Munich, GER, June 2009 (bib)
	T. Blum, N. Padoy, H. Feußner, N. Navab Workflow Mining for Visualization and Analysis of Surgeries International Journal of Computer Assisted Radiology and Surgery, Volume 3, Number 5, November 2008, pp. 379-386. The original publication is available online at www.springerlink.com. (bib)
	A. Ahmadi, N. Padoy, S.M. Heining, H. Feußner, M. Daumer, N. Navab Introducing Wearable Accelerometers in the Surgery Room for Activity Detection 7. Jahrestagung der Deutschen Gesellschaft f{\"u}r Computer-und Roboter-Assistierte Chirurgie (CURAC 2008) (bib)
	T. Blum, N. Padoy, H. Feußner, N. Navab Modeling and Online Recognition of Surgical Phases using Hidden Markov Models Medical Image Computing and Computer-Assisted Intervention (MICCAI 2008), New York, USA, September 2008, pp. 627-635. The original publication is available online at www.springerlink.com. (bib)
	N. Padoy, T. Blum, H. Feußner, M.O. Berger, N. Navab On-line Recognition of Surgical Activity for Monitoring in the Operating Room Proceedings of the 20th Conference on Innovative Applications of Artificial Intelligence (IAAI 2008) held in conjunction with the 23rd AAAI Conference on Artificial Intelligence, Chicago, Illinois, USA, July 2008, pp. 1718-1724 (bib)
	U.F. Klank, N. Padoy, H. Feußner, N. Navab An Automatic Approach for Feature Generation in Endoscopic Images International Journal of Computer Assisted Radiology and Surgery, Volume 3, Number 3-4, Saptember 2008, pp. 331-339 (bib)
	T. Blum, N. Padoy, H. Feußner, N. Navab Workflow Mining for Visualization and Analysis of Surgeries Proceedings of Computer Assisted Radiology and Surgery (CARS 2008), Barcelona, Spain, June 2008, pp. 134-135 (bib)
	N. Padoy, T. Blum, I. Essa, H. Feußner, M.O. Berger, N. Navab A Boosted Segmentation Method for Surgical Workflow Analysis Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007, pp. 102-109. The original publication is available online at www.springerlink.com. (bib)
	N. Navab, J. Traub, T. Sielhorst, M. Feuerstein, C. Bichlmeier Action- and Workflow-Driven Augmented Reality for Computer-Aided Medical Procedures IEEE Computer Graphics and Applications, vol. 27, no. 5, pp. 10-14, Sept/Oct, 2007 (bib)
	N. Padoy, M. Horn, H. Feußner, M.O. Berger, N. Navab Recovery of Surgical Workflow: a Model-based Approach Proceedings of Computer Assisted Radiology and Surgery (CARS 2007), 21st International Congress and Exhibition, Berlin, Germany, June 2007 (bib)
	T. Sielhorst, R. Stauder, M. Horn, T. Mussack, A. Schneider, H. Feußner, N. Navab Simultaneous replay of automatically synchronized videos of surgeries for feedback and visual assessment Journal of Computer Assisted Radiology and Surgery (CARS 2007), 21st International Congress and Exhibition, Berlin, Germany, Volume 2, Supplement 1, pp. 433-434 (bib)
	T. Blum, T. Sielhorst, N. Navab Advanced Augmented Reality Feedback for Teaching 3D Tool Manipulation New Technology Frontiers in Minimally Invasive Therapies, 2007, pp. 223-236 (bib)
	A. Ahmadi, T. Sielhorst, R. Stauder, M. Horn, H. Feußner, N. Navab Recovery of surgical workflow without explicit models Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006, pp. 420-428 (bib)
	T. Sielhorst, T. Blum, N. Navab Synchronizing 3D movements for quantitative comparison and simultaneous visualization of actions Fourth IEEE and ACM International Symposium on Mixed and Augmented Reality (ISMAR 2005), Vienna, Austria, October 2005, pp. 38-47. The original publication is available online at ieee.org. (bib)

Contact

If you are interested in this project, please send an email to Thomas Wendler, Joerg Traub or Tobias Sielhorst. Alternative projects in the field of medical navigation systems, molecular imaging and augmented reality visualization are available on request.