ResearchIssueMolecularImaging
Research in Molecular Imaging
Table of Content
Contact Person and Group Coordination
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Nassir Navab |
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Research Projects in Molecular Imaging
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Multispectral ReconstructionMultispectral imaging is an emerging modality for use in dermatological diagnosis which has the potential to offer quantitative measurements of the skin tissue, thus providing a more accurate diagnosis tool for a wide range of afflictions. Multispectral images are sequences of images taken at different wavelengths and due to their improved spectral discrimination, can offer insight into the distribution of collagen, melanin, and hemoglobin within skin lesions.The main motivation of this project is to provide dermatologists with a multispectral imaging system that allows quantification of skin lesions as well as tracking of disease progression in an automated fashion. To this end, both multispectral images are being acquired provide quantitative metrics of the skin, as well the size and geometry of the lesions. |
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Towards Deforming Motion Compensation Algorithms in Positron-Emission-TomographySubject of this project is the development of dedicated reconstruction algorithms for PET which take patient movements into account. Positron-emission-tomography (PET) is nowadays a well-established tool for diagnosing, staging and monitoring diseases in patients. However, due to the long acquisition times which are necessary for a PET scan, patient movements are often unavoidable. Patient motion during data acquisition can cause image blurring and even severe artifacts in the reconstructed image, thus posing a significant problem for further diagnosis and treatment. To date, available algorithms have been tested only on synthetic data since they rely on general transformation data of the patient which are currently not practically available. We aim at developing algorithms that work on partial transformation data that will be delivered e. g. by new laser cameras or com-bined PET/MRT machines. |
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EndoTOFPET-USThe project addresses and combines several objectives of the topics Health 2010.1.2-1, such as novel multimodality imaging tools, including a single-photon (quantum) counting PET detector head for the purpose of detecting and quantifying morphologic and functional markers and of developing new biomarkers of tumoural processes at the preclinical and clinical levels. Moreover the endoscopic approach, combined with an unprecedented PET timing resolution will allow more sensitive, more precise, lower radiation dose and less invasive imaging and intervention on small internal structures and lesions towards earlier detection and patient-tailored treatment of asymptomatic cancer types. |
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Kooperationsprojekt SFB 824 (3. Förderperiode) & BFSThe SFB824 (Sonderforschungsbereich 824: Central project for histopathology, immunohistochemistry and analytical microscopy) represents an interdisciplinary consortium which aims at the development of novel imaging technologies for the selection and monitoring of cancer therapy as an important support for personalized medicine. Z2, the central unit for comparative morphomolecular pathology and computational validation, provides integration, registration and quantification of data obtained from both macroscopic and (sub-)cellular in-vivo as well as ex-vivo imaging modalities with tissue-based morphomolecular readouts as the basis for the development and establishment of personalized medicine. In order to develop novel imaging technologies, co-annotation and validation of image data acquired by preclinical or diagnostic imaging platforms via tissue based quantitative morphomolecular methods is crucial. Light sheet microscopy will continue to close the gap between 3D data acquired by in-vivo imaging and 2D histological slices especially focusing on tumor vascularization. The Multimodal ImagiNg Data Flow StUdy Lab (MINDFUL) is a central system for data management in preclinical studies developed within SFB824. Continuing the close collaboration of pathology, computer sciences and basic as well as translational researchers from SFB824 will allow the Z2 to develop and subsequently provide a broad variety of registration and analysis tools for joint imaging and tissue based image standardization and quantification.The goal of the BFS Project: ImmunoProfiling using Neuronal Networks (IPN2) is to develop a method based on neuronal networks and recent advances in Deep Learning to allow characterization of a patient's tumor as ″hot″ or ″cold″ tumor depending on the identified ImmunoProfile. Recent research has shown that many tumors are infiltrated by immuno-competent cells, as well as that the amount, type and location of the infiltrated lymph nodes in primary tumors provide valuable prognostic information. In contrast to a ″cold tumor″, a ″hot tumor″ is characterized by an active immune system which the tumor has identified as threat. This identification provides the basis for selecting the therapy best suitable for the individual patient. |
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Advanced Robotics for Multi-Modal Interventional Imaging (RoBildOR)This project aims at developing advanced methods for robotic image acquisitions, enabling more flexible, patient- and process-specific functional and anatomical imaging with the operating theater. Using robotic manipulations, co-registered and dynamic imaging can be provided to the surgeon, allowing for optimal implementation of preoperative planning. In particular, this projects is the first one developing concepts for intraoperative SPECT-CT, and introduces intraoperative robotic Ultrasound imaging based on CT trajectory planning, enabling registration with angiographic data. With distinguished partners from Bavarian industry, this project has a fundamental contribution in developing safe, reliable, flexible, and multi-modal imaging technologies for the operating room of the future. |
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Developing Image Processing Techniques for Cryo Electron TomographyCryo-ET has recently emerged as a leading technique to investigate the three-dimensional(3D) structure of biological specimens at close-to-native state. It also bridges the gap between low-resolution imaging techniques (e.g. light microscopy) and high-resolution techniques (e.g. single particle electron microscopy). The technique consists of acquiring many two-dimensional (2D) projections of the structure under scrutiny at various tilt angles under cryogenic conditions. The 3D structure is recovered through a number of steps including projection alignment, reconstruction and de-nosing. The resolution of the reconstructed tomogram, however, is a affected by the low signal to noise ratio (SNR) of the projection images (typically 0.1 to 0.01) and the limited angular coverage (typically 60 to 70 ) resulting in wedge-shaped missing information in Fourier space, the so-called missing wedge; making the reconstruction process very challenging and demanding. |
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Real-time fusion of ultrasound and gamma probe for navigated localization of malignancyIntra-operative localization of non-superficial cancerous lesions in non-hollow organs like liver, kidney, etc is currently facilitated by intra-operative ultrasound (IOUS) and palpation. This yields a high rate of false positives due to benign abnormal regions and thus unnecessary resections with increased complications and morbidity. In this project we integrate functional nuclear information from gamma probes with IOUS, to provide a synchronized, real-time visualization that facilitates the detection of active tumors and metastases intra-operatively. The bet of this project is that the inclusion of an advanced, augmented visualization provides more reliability and confidence on classifying lesions prior to the resection. |
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Freehand SPECT for Sentinel Lymph Node LocalizationNuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging. |
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Intra-operative Beta Probe Surface Imaging and Navigation for Optimal Tumor ResectionIn minimally invasive tumor resection, the goal is to perform a minimal but complete removal of cancerous cells. In the last decades interventional beta probes supported the detection of remaining tumor cells. However, scanning the patient with an intraoperative probe and applying the treatment are not done simultaneously. The main contribution of this work is to extend the one dimensional signal of a nuclear probe to a four dimensional signal including the spatial information of the distal end of the probe. This signal can be then used to guide the surgeon in the resection of residual tissue and thus increase its spatial accuracy while allowing minimal impact on the patient. |
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PicoSEC - Endoscopic PET and Ultrasound ImagingPICOSEC (Pico-second Silicon photomultiplier-Electronics- & Crystal research) is an European Marie Curie training project. It aims to bring together early career researchers and experienced colleagues from across Europe, to take part in a structured, integrated and multidisciplinary training program for young researchers in an R&D project geared to develop a new class of ultra-fast photon detectors in PET and HEP. This R&D will be the core activity of a TOF-PET development for clinical applications and would open new perspectives in medical imaging and hence in the quality of patient treatment. The Consortium is composed of public and private organizations and based on a common research program, aiming to increase the skills exchange between public and private sectors.The overall project is divided in to different work packages that focus on specific aims while working towards common project goal. Our work package (WP) 5 has been assigned with the following tasks, 1. Provide tracking solutions for flexible endoscopy, trans-rectal ultrasound probe (TRUS), and endoscopic imaging devices, and evaluate their robustness and accuracy. 2. Based on tracking and imaging data, reconstruct volumes of interest from flexible endoscopic or TRUS detectors. 3. For orientation, guidance to specific regions of interest, and, where appropriate, through specific scanning protocols, provide navigation solutions. |
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In-PSMA Radioguided SurgeryWith the advent of 68Ga-HBED-PSMA PET hybrid imaging techniques, even small and atypical localized metastatic lesions of prostate cancer can be visualized. However, these lesions might not be easy to localize intraoperatively. The aim of project is to evaluate intraoperative detection of metastatic lesions using a gamma probe and freehand SPECT after injection of radioactive-labelled PSMA-ligands in correlation with postoperative histological findings. |
Related Publications
| 2020 | |
| A. K. Kogler, A. M. Polemi, S. Nair, S. Majewski, L. T. Dengel, C. L. Slingluff, B. Kross, S. J. Lee, J. E. McKisson?, J. McKisson?, A. G. Weisenberger, B. L. Welch, T. Wendler, P. Matthies, J. Traub, M. Witt, M. B. Williams
Evaluation of camera-based freehand SPECT in preoperative sentinel lymph node mapping for melanoma patients EJNMMI Research 10. https://doi.org/10.1186/s13550-020-00729-8. (bib) |
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| 2016 | |
| T. Wendler, S. Paepke
Axillary sentinel node aspiration biopsy: towards minimally invasive lymphatic staging in breast cancer Clinical and Translational Imaging volume 4, pages377–384. https://doi.org/10.1007/s40336-016-0205-8 (bib) |
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| A. Markus, A. K. Ray, D. Bolla, J. Müller, P.-A. Diener, T. Wendler, R. Hornung
Sentinel lymph node biopsy in endometrial and cervical cancers using freehand SPECT—first experience Gynecological Surgery volume 13, pages499–506. https://doi.org/10.1007/s10397-016-0969-x (bib) |
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| M. N. van Oosterom, T. Engelen, N. S. van den Berg, G. H. KleinJan?, H.G. van der Poel, T. Wendler, C. J. H. van de Velde, N. Navab, F.W.B. van Leeuwen
Navigation of a robot-integrated fluorescence laparoscope in preoperative SPECT/CT and intraoperative freehand SPECT imaging data: a phantom study J Biomed Opt 21(8):86008. https://doi.org/10.1117/1.jbo.21.8.086008 (bib) |
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| G. H. KleinJan?, N. S. van den Berg, M. N. van Oosterom, T. Wendler, M. Miwa, A. Bex, K. Hendricksen, S. Horenblas, F.W.B. van Leeuwen
Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting J Nucl Med 57(10):1650-1653. https://doi.org/10.2967/jnumed.115.171645 (bib) |
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C. Bluemel, P. Matthies, K. Herrmann, S. P. Povoski
3D Scintigraphic Imaging and Navigation in Radioguided Surgery: Freehand SPECT Technology and its Clinical Applications Expert Review of Medical Devices, 2016 (bib) |
| 2015 | |
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T. Lasser, J. Gardiazabal, M. Wieczorek, P. Matthies, J. Vogel, B. Frisch, N. Navab
Towards 3D thyroid imaging using robotic mini gamma cameras Bildverarbeitung für die Medizin, Lübeck, Germany, March 2015 (bib) |
| C. Vetter, T. Lasser, A. Okur, N. Navab
1D-3D Registration for Intra-operative Nuclear Imaging in Radio-guided Surgery IEEE Transactions on Medical Imaging 34(2):608-617, 2015 (bib) |
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A. Hartl, D. I. Shakir, T. Lasser, S. I. Ziegler, N. Navab
Detection models for freehand SPECT reconstruction Physics in Medicine and Biology 60(3):1031-1046, 2015 (bib) |
| 2014 | |
| O. R. Brouwer, N. S. van den Berg, H. M. Mathéron, T. Wendler, H.G. van der Poel, S. Horenblas, R. A. Valdés-Olmos, F.W.B. van Leeuwen
Feasibility of intraoperative navigation to the sentinel node in the groin using preoperatively acquired single photon emission computerized tomography data: transferring functional imaging to the operating room J Urol 192(6):1810-6. https://doi.org/10.1016/j.juro.2014.03.127 (bib) |
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A. Okur, C. Hennersperger, J.B. Runyan, J. Gardiazabal, M. Keicher, S. Paepke, T. Wendler, N. Navab
fhSPECT-US Guided Needle Biopsy of Sentinel Lymph Nodes in the Axilla: Is it Feasible? Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, Lecture Notes in Computer Science Volume 8673, 2014, pp 577-584 (bib) |
| I. Einspieler, A.R. Novotny, A. Okur, M. Essler, M. E. Martignoni
First Experience With Image-guided Resection of Paraganglioma Clinical Nuclear Medicine, Volume 39, Issue:8, August 2014. (bib) |
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A. Okur, R. Voigt, R. Stauder, N. Navab
Investigation of performance log files of freehand SPECT acquisitions for usage characteristics and surgical phase determination The 7th Hamlyn Symposium on Medical Robotics, London, UK, July 2014 (bib) |
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P. Matthies, J. Gardiazabal, A. Okur, J. Vogel, T. Lasser, N. Navab
Mini Gamma Cameras for Intra-operative Nuclear Tomographic Reconstruction Medical Image Analysis 18(8):1329-1336, 2014 (bib) |
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A. Okur, C. Gerngross, A. Schnelzer, A. Ehlerding, M. Keicher, S. Wiesner, S. Paepke, K. Scheidhauer, T. Wendler
First experience with fused ultrasound / freehand SPECT system for hybrid lymphatic mapping in breast cancer patients 52. Jahrestagung der Deutschen Gesellschaft fuer Nuklearmedizin, Hannover, Germany, Mar. 26 - 29, 2014. (bib) |
| A.L. Mihaljevic, A. Rieger, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring innovative freehand SPECT to the operating room: First experiences with sentinel lymph node biopsy in malignant melanoma European Journal of Surgical Oncology (EJSO), Volume 40, Issue 1, January 2014. (bib) |
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| 2013 | |
| J. Gardiazabal, T. Reichl, A. Okur, T. Lasser, N. Navab
First flexible robotic intra-operative nuclear imaging for image-guided surgery Information Processing in Computer Assisted Interventions (IPCAI), Heidelberg, Germany, June 26, 2013 (bib) |
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| C. Bluemel, A. Schnelzer, A. Okur, A. Ehlerding, S. Paepke, K. Scheidhauer, M. Kiechle
Freehand SPECT for image-guided sentinel lymph node biopsy in breast cancer European Journal of Nuclear Medicine and Molecular Imaging. The original publication is available online at www.springerlink.com (bib) |
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| J. Vogel, T. Lasser, J. Gardiazabal, N. Navab
Trajectory optimization for intra-operative nuclear tomographic imaging Medical Image Analysis 17(7):723-731, 2013. (bib) |
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| N. Aubry, E. Auffray, F. B. Mimoun, N. Brillouet, R. Bugalho, , O. Charles, D. Cortinovis, P. Courday, A. Cserkaszky, C. Damon, K. Doroud, J.-M. Fischer, G. Fornaro, J.-M. Fourmigue, B. Frisch, B. Fuerst, J. Gardiazabal, K. Gadow, E. Garutti, C. Gaston, A. Gil-Ortiz, E. Guedj, T. Harion, P. Jarron, J. Kabadanian, T. Lasser, R. Laugier, P. Lecoq, D. Lombardo, S. Mandai, E. Mas, T. Meyer, O. Mundler, N. Navab, C. Ortigão, M. Paganoni, D. Perrodin, M. Pizzichemi, J. O. Prior, T. Reichl, M. Reinecke, M. Rolo, H.-C. Schultz-Coulon, M. Schwaiger, W. Shen, A. Silenzi, J. C. Silva, , I. Somlai-Schweiger, R. Stamen, J. Traub, J. Varela, V. Veckalns, V. Vidal, J. Vishwas, T. Wendler, C. Xu, S. I. Ziegler, M. Zvolsky
EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography JINST 8 C04002. https://doi.org/10.1088/1748-0221/8/04/C04002 (bib) |
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| 2012 | |
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A. Schnelzer, A. Ehlerding, C. Bluemel, A. Okur, K. Scheidhauer, S. Paepke, M. Kiechle
Showcase of Intraoperative 3D Imaging of the Sentinel Lymph Node in a Breast Cancer Patient using the New Freehand SPECT Technology Breast Care 2012;7:484-486 (bib) |
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J. Vogel, T. Reichl, J. Gardiazabal, N. Navab, T. Lasser
Optimization of Acquisition Geometry for Intra-operative Tomographic Imaging Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Nice, France, October 2012 (bib) |
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I. Einspieler, A. Okur, A.R. Novotny, M. E. Martignoni, K. Scheidhauer
Case Report - Image-guided Resection of Paraganglioma 32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib) |
| A. Rieger, J. Saeckl, R. Hein, A. Okur, T. Wendler, K. Scheidhauer, T. Schuster, H. Friess, M. E. Martignoni
Transferring Innovative Freehand SPECT to the Operating Room - First Experiences with Sentinel Lymphonodectomy in Malignant Melanoma 32nd Congress of the European Society of Surgical Oncology, Valencia, Spain, September 2012 (bib) |
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N. Navab, T. Blum, L. Wang, A. Okur, T. Wendler
First Deployments of Augmented Reality in Operating Rooms IEEE Computer, Volume 45, Issue 7, pp. 48-55 (bib) |
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C. Bluemel, A. Schnelzer, A. Rieger, A. Ehlerding, A. Okur, C. Gerngross, M. E. Martignoni, K. Scheidhauer, M. Schwaiger
3D navigated (radio-guided) sentinel lymph node biopsy using freehand SPECT : final evaluation of Munich's pilot experience in the operating room 50. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Messe Bremen, Germany, April 2012 (bib) |
| A. Hartl, D. I. Shakir, R. Kojchev, N. Navab, S. I. Ziegler, T. Lasser
Freehand SPECT reconstructions using look up tables SPIE Medical Imaging Conference, February 4 - February 9 2012, San Diego, USA (bib) |
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| D. I. Shakir, A. Hartl, F. R. Schneider, J. Pulko, S. I. Ziegler, N. Navab, T. Lasser
Two new ad-hoc models of detection physics and their evaluation for navigated beta probe surface imaging Proceedings of SPIE Visualization, Image-Guided Procedures, and Modeling Conference, San Diego, CA, USA, February 2012 (bib) |
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| 2011 | |
| C. Vetter, T. Lasser, T. Wendler, N. Navab
1D-3D Registration for Functional Nuclear Imaging Medical Image Computing and Computer Assisted Intervention (MICCAI), Toronto, Canada, September 20-24 2011. (bib) |
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| A. Okur, A. Ahmadi, A. Bigdelou, T. Wendler, N. Navab
MR in OR: First analysis of AR/VR visualization in 100 intra-operative Freehand SPECT acquisitions The 10th IEEE and ACM International Symposium on Mixed and Augmented Reality (ISMAR), Basel, Switzerland, Oct. 26 - 29, 2011. (bib) |
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| A. Hartl, T. Lasser, N. Navab, S. I. Ziegler
Impact of acquisition geometry and physical model on Freehand SPECT reconstructions IEEE Medical Imaging Conference, October 23 - October 29 2011, Valencia, Spain (bib) |
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| C. Bluemel, A. Schnelzer, A. Ehlerding, A. Okur, K. Scheidhauer, M. Kiechle, M. Schwaiger
Evaluation of freehand SPECT in sentinel lymph node biopsy of breast cancer Proceedings of the Annual Congress of the European Association of Nuclear Medicine (EANM), Birmingham, UK, October 2011 (bib) |
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| D. I. Shakir, T. Lasser, A. Drzezga, S. I. Ziegler, N. Navab
Evaluation of Navigated Beta-Probe Surface Imaging on a Realistic 3D Phantom Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), Valencia, Spain, October 2011 (bib) |
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A. Rieger, J. Saeckl, B. Belloni, R. Hein, A. Okur, K. Scheidhauer, T. Wendler, J. Traub, H. Friess, M. E. Martignoni
First Experiences with Navigated Radio-Guided Surgery Using Freehand SPECT Case Reports in Oncology, August 2011 (bib) |
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A. Okur, C. Bluemel, A. Ehlerding, K. Scheidhauer, A. Schnelzer
Meme kanseri cerrahisinde freehandSPECT ile ilk tecrube: Aksiller sentinel lenf nodu biyopsisinde uc boyutlu navigasyon ve kalite guvencesi XI. Ulusal Meme Hastaliklari Kongresi, Antalya, Turkey, Oct. 5 - 9, 2011. (bib) |
| C. Lapa, J. Saeckl, A. Rieger, C. Bluemel, A. Okur, T. Wendler, M. E. Martignoni, K. Scheidhauer
Investigating added value of freehand SPECT in sentinel node biopsy of melanomas Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib) |
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| C. Bluemel, A. Ehlerding, C. Lapa, A. Okur, T. Wendler, A. Schnelzer, K. Scheidhauer
Improvements in sentinel node biopsy of breast cancer using freehand SPECT Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), San Antonio, Texas, USA, June 2011 (bib) |
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| D. I. Shakir, A. Hartl, N. Navab, S. I. Ziegler
Evaluation of an ad hoc model of detection physics for navigated beta-probe surface imaging Proceedings of SPIE Visualization, Image-Guided Procedures, and Modeling Conference, Lake Buena Vista (Orlando Area), FL, USA, February 2011 (bib) |
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| 2010 | |
| T. Wendler, T. Lasser, S. I. Ziegler, K. Scheidhauer
Freehand SPECT/US: new approach for intraoperative hybrid imaging of sentinel nodes Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| T. Wendler, D. Zaeuner, S. Wiesner, K. Scheidhauer
Fused SPECT/CT and real-time video visualization for intraoperative guidance in SLNB of head and neck malignancies Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| K. Scheidhauer, A. Ehlerding, J. Saeckl, A. Rieger, K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Wendler
Feasibility evaluation of freehand SPECT for intraoperative 3D lymphatic mapping Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, S. Nicolini, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT 3D-imaging for sentinel lymph node mapping in breast cancer: preliminary preoperative study for future intraoperative use in the operating room Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| M. C. Kreissl, T. Wendler, K. Herrmann, K. Scheidhauer
Freehand SPECT: First experiences with a new method of 3D-SLN mapping in melanoma Proceedings of the International Sentinel Node Society Meeting, Yokohama, Japan, 2010 (bib) |
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| D. I. Shakir, N. Navab, S. I. Ziegler
Acquisition Model for Iterative Reconstruction of Navigated Beta-Probe Surface Images Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), Knoxville, TN, USA, November 2010 (bib) |
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| I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT for sentinel lymph node biopsy: first clinical experience Proceedings of EANM 2010, Vienna, Austria, October 2010 (bib) |
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| A. K. Buck, A. Ehlerding, J. Saeckl, K. Herrmann, T. Wendler, M. E. Martignoni, A. Schnelzer, M. Schwaiger
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of EANM 2010, Vienna, Austria, October 2010 (bib) |
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| A. Schnelzer, A. Ehlerding, T. Chen, T. Wendler, K. Scheidhauer, S. Paepke, M. Kiechle
Sentinel lymph node detection with intraoperative freehand SPECT in breast cancer patients Proceedings of the Annual Meeting of the German Society of Gynecology and Obstetrics (DGGG) 2010, Munich, Germany, October 2010 (bib) |
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| A. Ehlerding, A. Schnelzer, T. Wendler, K. Herrmann, T. Lasser, K. Scheidhauer, O. Kutter, T. Schuster, M. Schwaiger, A. K. Buck, S. I. Ziegler, N. Navab, S. Paepke, M. Kiechle
Vorstellung der Pilotstudie zur 3D-Darstellung des Wächterlymphknotens bei Brustkrebspatientinnen mittels Freehand-SPECT Proceedings of Annual Meeting of the German Society of Senology (DGS), Hamburg, Germany, Jul. 2010 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Lasser, J. Traub, A. Ehlerding, J. Saeckl, N. Navab, M. Kiechle, H. Friess, M. Schwaiger, S. I. Ziegler, A. K. Buck
Visione 3-D SPECT intraoperatoria: una nuova metodica per chirurgia radioguiata Proceedings of SICO 2010, Milan, Italy, June 2010 (bib) |
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| I. Santi, L. Fantini, K. Herrmann, Ch. Fuccio, T. Wendler, P. Caroli, P. Castelucci, A. K. Buck, M. Schwaiger, S. Fanti
Freehand SPECT for sentinel lymph node biopsy: first clinical experience Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib) |
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| D. I. Shakir, J. Bieniarz, S. Pirsig, T. Wendler, N. Navab, S. I. Ziegler
A first study on biological feasibility of intraoperative control of tumor resection borders with navigated beta-probe surface imaging Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, UT, USA, June 2010 (bib) |
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| M. C. Kreissl, A. Okur, T. Chen, A. Bartel, T. Wendler, K. Scheidhauer
Pilot study of freehand SPECT for lymphatic mapping in melanoma in upper body Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib) |
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| K. Herrmann, A. Schnelzer, M. E. Martignoni, T. Wendler, A. K. Buck
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of the Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, Utah, USA, June 2010 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, A. Ehlerding, K. Scheidhauer, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First Demonstration of 3D Lymphatic Mapping using freehand SPECT Proceedings of the International Conference on Sentinel Node Biopsy and Radioguided Head & Neck Surgery (SNB), Copenhagen, Denmark, May 2010 (bib) |
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| J. Saeckl, A. Ehlerding, K. Herrmann, T. Wendler, M. Schwaiger, M. Kiechle, H. Friess, A. K. Buck, A. Schnelzer, M. E. Martignoni
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of the International Conference on Sentinel Node Biopsy and Radioguided Head & Neck Surgery (SNB), Copenhagen, Denmark, May 2010 (bib) |
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| A. K. Buck, A. Schnelzer, T. Wendler, K. Herrmann, T. Lasser, J. Traub, O. Kutter, T. Schuster, A. Ehlerding, K. Scheidhauer, M. Kiechle, N. Navab, S. I. Ziegler, M. Schwaiger
First demonstration of 3D lymphatic mapping in breast cancer using freehand SPECT Proceedings of DGN Nuklearmedizin 2010, Leipzig, Germany, April 2010 (bib) |
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| K. Herrmann, A. Schnelzer, T. Wendler, M. Hoyer, D. Weisgerber, T. Lasser, S. Paepke, M. E. Martignoni, M. Kiechle, N. Navab, S. I. Ziegler, M. Schwaiger
Evaluation of feasibility of freehand SPECT in the operating room Proceedings of DGN Nuklearmedizin 2010, Leipzig, Germany, April 2010 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, A. Ehlerding, K. Scheidhauer, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First demonstration of 3-D lymphatic mapping in breast cancer using freehand SPECT European Journal of Nuclear Medicine and Molecular Imaging, Springer Berlin/Heidelberg, 2010 Aug;37(8):1452-61. Epub 2010 Mar 31. (bib) |
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| 2009 | |
| J. Traub, K. Herrmann, T. Lasser, N. Navab, S. I. Ziegler, A. K. Buck, T. Wendler
Freehand SPECT/Ultrasound Fusion for Hybrid Image-guided Resection Proceedings of RSNA 2009, Chicago, USA, December 2009 (bib) |
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| T. Wendler, K. Herrmann, A. Schnelzer, T. Lasser, J. Traub, O. Kutter, T. Schuster, M. Kiechle, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
Clinical introduction of freehand SPECT for image-guided sentinel lymph node biopsy Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Wendler, X. Feng, K. Herrmann, T. Lasser, J. Traub, S. I. Ziegler, N. Navab, A. K. Buck
2D/3D registration of freehand SPECT and planar scintigraphy for clinical evaluation of 3D thyroid scintigraphy Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Wendler, K. Herrmann, T. Lasser, J. Traub, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First experience with freehand SPECT for lymphatic mapping in melanoma in upper body Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Wendler, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
Freehand SPECT / ultrasound fusion for hybrid image-guided resection Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| T. Lasser, A. Duliu, T. Wendler, S. I. Ziegler, N. Navab
Interactive Reconstruction for Freehand SPECT: An Approach to Acquisition Guidance? Proceedings of Annual Congress of the European Association of of Nuclear Medicine (EANM 2009), Barcelona, Spain, October 2009 (bib) |
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| C. Özgür, J. Bieniarz, T. Lasser, S. I. Ziegler, N. Navab, T. Wendler
Phenomenological Models for intraoperative Positron Emission Surface Imaging using Handheld Probes Proceedings of World Congress in Medical Physics and Biomedical Engineering (WC 2009), Munich, Germany, September 2009 (bib) |
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| X. Feng, K. Szajkowska, T. Lasser, S. I. Ziegler, N. Navab, T. Wendler
2D/3D registration of freehand SPECT and planar scintigraphy for clinical evaluation of 3D thyroid scintigraphy Proceedings of World Congress in Medical Physics and Biomedical Engineering (WC 2009), Munich, Germany, September 2009 (bib) |
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| J. Traub, K. Herrmann, T. Wendler, T. Lasser, M. Schwaiger, N. Navab, S. I. Ziegler, A. K. Buck
First clinical results of freehand SPECT for lymphatic mapping in breast cancer Proceedings of the Molekulare Bildgebung (MOBI), Berlin, Germany, Jun. 2009 (bib) |
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| T. Wendler, K. Herrmann, T. Lasser, J. Traub, M. Schwaiger, S. I. Ziegler, N. Navab, A. K. Buck
Freehand SPECT: first in-vivo evaluation and comparison to conventional lymphatic mapping Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2009), Toronto, Canada, June 2009 (bib) |
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| T. Wendler, X. Feng, T. Lasser, K. Herrmann, J. Traub, K. Scheidhauer, S. I. Ziegler, D. Lenhart, J. Grahneis, M. Schwaiger, N. Navab, A. K. Buck
Freehand SPECT for 3D thyroid scintigraphy: first patient report Proceedings of DGN Nuklearmedizin 2009, Leipzig, Germany, April 2009 (bib) |
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| K. Herrmann, T. Wendler, T. Chen, A. Bartel, T. Lasser, K. Scheidhauer, J. Traub, T. Schuster, S. I. Ziegler, M. Schwaiger, A. K. Buck, N. Navab
Freehand SPECT: first in-vivo use for lymphatic mapping and comparison to conventional imaging Proceedings of DGN Nuklearmedizin 2009, Leipzig, Germany, April 2009 (bib) |
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| 2008 | |
| T. Wendler, T. Lasser, A. K. Buck, C. Özgür, M. Schwaiger, S. I. Ziegler, N. Navab
First in Vivo Use of a Fused Gamma Ultrasound System Proceedings of RSNA 2008, Chicago, USA, December 2008 (bib) |
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| T. Wendler, T. Lasser, S. I. Ziegler, N. Navab
Towards Confident 3D Tomographic Reconstruction for Asymmetric, Sparse Detector Geometries Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib) |
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| T. Lasser, T. Wendler, S. I. Ziegler, N. Navab
Towards Reproducibility of Freehand 3D Tomographic Nuclear Imaging Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib) |
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| T. Lasser, T. Wendler, J. Traub, S. I. Ziegler, N. Navab
Definition of optimal collimator geometries for 3D tomographic thyroid scintigraphy using navigated gamma probes Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008 (bib) |
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| T. Wendler, T. Lasser, A. K. Buck, J. Traub, M. Schwaiger, S. I. Ziegler, N. Navab
First case report of 3D tomographic thyroid scintigraphy with tracked gamma probes Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008, Eur J Nuc Med Mol Imaging, vol. 35 (Suppl. 2), S129 (bib) |
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| T. Wendler, A. Hartl, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
Tracking-based statistical correction for radio-guided cancer surgery Proceedings of World Molecular Imaging Congress (WMIC 2008), Nice, France, September 2008 (bib) |
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| T. Wendler, J. Traub, T. Lasser, M. Feuerstein, J. Vogel, S. I. Ziegler, N. Navab
Combined ultrasound and gamma probe imaging for examination of thyroid nodules Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib) |
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| T. Wendler, A. Hartl, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
3D Intra-operative nuclear imaging for SLNB in neck Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib) |
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| A. Hartl, T. Wendler, J. Traub, T. Lasser, S. I. Ziegler, N. Navab
Confident radioactivity surface reconstruction for control of resection borders Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib) |
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| N. Navab, J. Traub, A. K. Buck, S. I. Ziegler, T. Wendler
Navigated nuclear probes for intra-operative functional imaging Proceedings of 5th IEEE International Symposium on Biomedical Imaging (ISBI 2008), Paris, France, May 14 - 17 2008, pp. 1395-1398 (bib) |
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| 2007 | |
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T. Wendler, M. Feuerstein, J. Traub, T. Lasser, J. Vogel, F. Daghighian, S. I. Ziegler, N. Navab
Real-time fusion of ultrasound and gamma probe for navigated localization of liver metastases Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2007, LNCS 4792 (2), pp. 909-917 (bib) |
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T. Wendler, A. Hartl, T. Lasser, J. Traub, F. Daghighian, S. I. Ziegler, N. Navab
Towards intra-operative 3D nuclear imaging: reconstruction of 3D radioactive distributions using tracked gamma probes Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2 2007, LCNS 4792 (2), pp. 252-260 (bib) |
| A. Hartl, T. Wendler, T. Lasser, J. Traub, S. I. Ziegler, N. Navab
Towards intra-operative 3D nuclear imaging: development and evaluation of ad hoc models Proceedings of Jahrestagung der deutschen Gesselschaft für Computer- und Roboterassistierte Chirurgie e.V. (CURAC 2007), Karlsruhe, Germany, October 2007 (bib) |
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N. Navab, J. Traub, T. Sielhorst, M. Feuerstein, C. Bichlmeier
Action- and Workflow-Driven Augmented Reality for Computer-Aided Medical Procedures IEEE Computer Graphics and Applications, vol. 27, no. 5, pp. 10-14, Sept/Oct, 2007 (bib) |
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T. Wendler, J. Traub, A. Hartl, T. Lasser, M. Burian, A. K. Buck, F. Daghighian, M. Schwaiger, S. I. Ziegler, N. Navab
Adding navigation to radio-guided surgery: new possibilities, new problems, new solutions Proceedings of Russian Bavarian Conference on Biomedical Engineering (RBC Biomed 2007), Erlangen, Germany, July 2-3, 2007, pp. 96-100 (bib) |
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T. Wendler, A. Hartl, J. Traub, S. I. Ziegler, N. Navab
Intraoperative nuclear imaging using navigated gamma-probes for tumor localization Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2007), Washington D.C., USA, June 2007 (bib) |
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T. Wendler, J. Traub, S. I. Ziegler, N. Navab
Validation of navigated beta-probe imaging with PET/CT-generated activity surfaces. New approach in radio-guided resection for FDG-positive tumors Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2007), Washington D.C., USA, June 2007; Meeting Abstracts 48: 46P-b. (bib) |
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O. Kishenkov, T. Wendler, J. Traub, S. I. Ziegler, N. Navab
Method for projecting functional 3D information onto anatomic surfaces: Accuracy improvement for navigated 3D beta-probes Proceedings of Bildverarbeitung fuer die Medizin (BVM 2007), Munich, Germany, March 2007, pp.66-70 (bib) |
| 2006 | |
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T. Wendler, J. Traub, S. I. Ziegler, N. Navab
Navigated three dimensional beta probe for optimal cancer resection Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 1-6 2006, LNCS 4190 (1), pp. 565-569 (bib) |
Working Group
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