Benjamin Frisch

Dr. Benjamin Frisch Senior Research Manager Technische Universität München Fakultät für Informatik Chair for Computer Aided Medical Procedures & Augmented Reality Boltzmannstr. 3 85748 Garching bei München room: MI 03.13.058 phone: +49 89 289 19401 mail: Laboratory Manager Klinikum Rechts der Isar Interdisziplinäres Forschungslabor Ismaninger Str. 22 81675 München room: 01.3 a-c phone: +49 89 4140 6457

Research Interest

The development of modern medical procedures requires a strong link between health sciences, engineering research and industry. Translational research, the discipline that looks for practical applications of basic science, actively develops approaches that improve the quality of healthcare, keeping commercial opportunities in mind.

Being hosted by CAMP, with its renowned expertise in medical algorithmics and augmented reality, I enjoy having my laboratory at the TUM university hospital, Klinikum Rechts der Isar. The close contact with medical experts from many specialities allows for a better understanding of unmet clinical needs, while the accumulated knowledge of CAMP provides many options to define new or improve existing procedures. Being embedded in Bavaria's dynamic medical industry, I value good contacts with both established and start-up companies.

Although I focus my research on interventional imaging and medical robotics, I look forward to discuss ideas and define new projects on any topic at the crossroads of medicine and engineering.

Short Curriculum Vitae

• 2013 - now : Staff Scientist at TUM
  • 2014 - now : Visiting researcher at Klinik für Nukklearmedizin, Klinikum Rechts der Isar, TUM (unpaid)
  • 2013 - now : External collaborator at CERN (unpaid)
• 2010 - 2013: Senior Fellow at CERN
• 2007 - 2010: Doctoral student at CERN (PhD obtained in 2012)
• 2005 - 2006: Software quality manager at Siemens PSE, medical division
• 2001 - 2007: studies in technical physics at TU Wien

Projects

with public funding

Advanced Robotics for Multi-Modal Interventional Imaging (RoBildOR) This project aims at developing advanced methods for robotic image acquisitions, enabling more flexible, patient- and process-specific functional and anatomical imaging with the operating theater. Using robotic manipulations, co-registered and dynamic imaging can be provided to the surgeon, allowing for optimal implementation of preoperative planning. In particular, this projects is the first one developing concepts for intraoperative SPECT-CT, and introduces intraoperative robotic Ultrasound imaging based on CT trajectory planning, enabling registration with angiographic data. With distinguished partners from Bavarian industry, this project has a fundamental contribution in developing safe, reliable, flexible, and multi-modal imaging technologies for the operating room of the future.

Inside-Out Tracking Current tracking solutions routinely used in a clinical, potentially surgically sterile, environment are limited to mechanical, electromagnetic or classic optical tracking. Main limitations of these technologies are respectively the size of the arm, the influence of ferromagnetic parts on the magnetic field and the line of sight between the cameras and tracking targets. These drawbacks limit the use of tracking in a clinical environment. The aim of this project is the development of so-called inside-out tracking, where one or more small cameras are fixed on clinical tools or robotic arms to provide tracking, both relative to other tools and static targets. These developments are funded from the 1st of January 2016 to 31st of December 2017 by the ZIM project Inside-Out Tracking for Medical Applications (IOTMA).

Freehand SPECT for Sentinel Lymph Node Localization Nuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging.

without public funding

In-PSMA Radioguided Surgery With the advent of 68Ga-HBED-PSMA PET hybrid imaging techniques, even small and atypical localized metastatic lesions of prostate cancer can be visualized. However, these lesions might not be easy to localize intraoperatively. The aim of project is to evaluate intraoperative detection of metastatic lesions using a gamma probe and freehand SPECT after injection of radioactive-labelled PSMA-ligands in correlation with postoperative histological findings.

Student Projects

We are permanently looking for motivated students for IDP, master thesis, bachelor thesis and HiWi^? positions at IFL. Please contact me directly if you are interested in working on robotic imaging, nuclear medicine or any translation research with ongoing clinical applications!

Available:

Teaching

Responsible

• Lab Course Project Management and Software Development for Medical Applications (2016WiSe)
• Seminar Non-engineering Aspects of Medical Robotics (2016WiSe)
• Lab Course BioInnovation: from unmet clinical needs to solution concepts (2016SoSe)
• Lab Course Project Management and Software Development for Medical Applications (2016SoSe)
• Lab Course BioInnovation: BioInnovation: from unmet clinical needs to solution concepts (2015WiSe)
• Lab Course From an Unmet Clinical Need to a Promising Concept - FUN2Concept (2015SoSe)
• Seminar Innovations in Robotic Imaging (2015SoSe)
• Seminar Innovations in Computer Aided Surgery (2014WiSe)
• Seminar Innovations in Medical Robotics (2014SoSe)
• Lecture Computer Aided Medical Procedures 2 (2014SoSe)

Co-Responsible

• Lab Course BioInnovation: from unmet clinical needs to solution concepts (2016WiSe)
• Lecture Introduction to Surgical Robotics (2016WiSe)
• Lecture [[Chair.TeachingSs16MedicalAR][Medical Augmented Reality] (2016SoSe)
• Lecture Introduction to Surgical Robotics (2015WiSe)
• Lab Course Project Management and Software Development for Medical Applications (2015WiSe)

Lecturer

• Lecture Computer Aided Medical Procedures 1 (2015WiSe)
• Lecture Computer Aided Medical Procedures 1 (2014WiSe)

Publications at CAMP

2018
	J. Esteban, W. Simson, S. Requena, A. Rienmüller, S. Virga, O. Zettinig, B. Frisch, S. Drazen, Y.-M. Ryang , N. Navab, C. Hennersperger Robotic Ultrasound-Guided Facet Joint Insertion International Journal of Computer Assisted Radiology and Surgery / 9th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Berlin, Germany, June 2018. (bib)
2017
	O. Zettinig, J. Rackerseder, B. Lentes, T. Maurer, K. Westenfelder, M. Eiber, B. Frisch, N. Navab Preconditioned Intensity-Based Prostate Registration using Statistical Deformation Models IEEE International Symposium on Biomedical Imaging (ISBI), Melbourne, April 2017. (bib)
	J. Rackerseder, A. Luque, C. Düwel, N. Navab, B. Frisch Fully automated multi-modal anatomic atlas generation using 3D-Slicer Workshops Bildverarbeitung fuer die Medizin (BVM), Heidelberg, March 12-14, 2017. (bib)
	R. Göbl, S. Virga, J. Rackerseder, B. Frisch, N. Navab, C. Hennersperger Acoustic window planning for ultrasound acquisition International Journal of Computer Assisted Radiology and Surgery / 8th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Barcelona, Spain, June 2017. The original publication is available online at link.springer.com (bib)
	O. Zettinig, B. Frisch, S. Virga, M. Esposito, A. Rienmüller, B. Meyer, C. Hennersperger, Y.-M. Ryang , N. Navab 3D Ultrasound Registration-based Visual Servoing for Neurosurgical Navigation International Journal of Computer Assisted Radiology and Surgery, Volume 12, Issue 9, pp 1607–1619, 2017. The original publication is available online at link.springer.com (bib)
2016
	B. Frisch, O. Zettinig, B. Fuerst, S. Virga, C. Hennersperger, N. Navab Collaborative Robotic Ultrasound: Towards Clinical Application Radiological Society of North America Annual Meeting, Chicago, USA, 2016 (bib)
	B. Busam, M. Esposito, B. Frisch, N. Navab Quaternionic Upsampling: Hyperspherical Techniques for 6 D-o-F Pose Tracking International Conference on 3DVision (3DV), Stanford University, California, USA, October 2016 (bib)
	C. Hennersperger, B. Fuerst, S. Virga, O. Zettinig, B. Frisch, T. Neff, N. Navab Towards MRI-Based Autonomous Robotic US Acquisitions: A First Feasibility Study IEEE Transactions on Medical Imaging, vol. 36, iss. 2, 2017 The original publication (open access) is available online at ieeexplore.ieee.org (bib)
	J. Gardiazabal, P. Matthies, J. Vogel, B. Frisch, N. Navab, S. I. Ziegler, T. Lasser Flexible Mini Gamma Camera Reconstructions of Extended Sources using Step and Shoot and List Mode Medical Physics 43(12):6418-6428, 2016. (bib)
	S. Virga, O. Zettinig, M. Esposito, K. Pfister, B. Frisch, T. Neff, N. Navab, C. Hennersperger Automatic Force-Compliant Robotic Ultrasound Screening of Abdominal Aortic Aneurysms IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), Daejeon, South Korea, October 2016. The original publication is available online at ieeexplore.ieee.org (bib)
	M. Esposito, B. Busam, C. Hennersperger, J. Rackerseder, N. Navab, B. Frisch Multimodal US-Gamma Imaging using Collaborative Robotics for Cancer Staging Biopsies International Journal of Computer Assisted Radiology and Surgery (bib)
	R. Kojcev, B. Fuerst, O. Zettinig, J. Fotouhi, S.C. Lee, B. Frisch, R. Taylor, E. Sinibaldi, N. Navab Dual-Robot Ultrasound-Guided Needle Placement: Closing the Planning-Imaging-Action Loop International Journal of Computer Assisted Radiology and Surgery / International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Heidelberg, June 2016. The original publication is available online at link.springer.com (bib)
	N. Navab, C. Hennersperger, B. Frisch, B. Fuerst Personalized, Relevance-based Multimodal Robotic Imaging and Augmented Reality for Computer Assisted Interventions Medical Image Analysis (bib)
	O. Zettinig, B. Fuerst, R. Kojcev, M. Esposito, M. Salehi, W. Wein, J. Rackerseder, B. Frisch, N. Navab Toward Real-time 3D Ultrasound Registration-based Visual Servoing for Interventional Navigation IEEE International Conference on Robotics and Automation (ICRA), Stockholm, May 2016. The original publication is available online at ieeexplore.ieee.org (bib)
2015
	B. Busam, M. Esposito, S. Che'Rose, N. Navab, B. Frisch A Stereo Vision Approach for Cooperative Robotic Movement Therapy International Conference on Computer Vision Workshop (ICCVW), Santiago, Chile, December 2015 [oral]. (bib)
	B. Fuerst, J. Sprung, F. Pinto, B. Frisch, T. Wendler, H. Simon, L. Mengus, N. S. van den Berg, H.G. van der Poel, F.W.B. van Leeuwen, N. Navab First Robotic SPECT for Minimally Invasive Sentinel Lymph Node Mapping IEEE Transactions on Medical Imaging, 2015. (bib)
	P. Matthies, B. Frisch, J. Vogel, T. Lasser, M. Friebe, N. Navab Inside-Out Tracking for Flexible Hand-held Nuclear Tomographic Imaging IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
	J. Gardiazabal, B. Frisch, P. Matthies, J. Vogel, S. I. Ziegler, N. Navab, T. Lasser List-Mode Reconstruction for Continuous Freehand SPECT Acquisitions IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
	B. Frisch, et al. First Results with an Interventional Handheld PET IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
	F. Pinto, B. Fuerst, B. Frisch, N. Navab Radiopositive Tissue Displacement Compensation for SPECT-guided Surgery Proceedings of the 18th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Munich, Germany, October 2015 (bib)
	M. Esposito, B. Busam, C. Hennersperger, J. Rackerseder, A. Lu, N. Navab, B. Frisch Cooperative Robotic Gamma Imaging: Enhancing US-guided Needle Biopsy Proceedings of the 18th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Munich, Germany, October 2015 [oral]. (bib)
	O. Zettinig, A. Shah, C. Hennersperger, M. Eiber, C. Kroll, H. Kübler, T. Maurer, F. Milletari, J. Rackerseder, C. Schulte-zu-Berge, E. Storz, B. Frisch, N. Navab Multimodal Image-Guided Prostate Fusion Biopsy based on Automatic Deformable Registration International Journal of Computer Assisted Radiology and Surgery / 6th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Barcelona, June 2015. The original publication is available online at link.springer.com (bib)
	A. Shah, O. Zettinig, E. Storz, T. Maurer, M. Eiber, N. Navab, B. Frisch Challenges in Multimodal Image-guided Targeted Prostate Biopsy Hamlyn Symposium on Medical Robotics, London, UK, June 2015 (bib)
	B. Frisch, T. Maurer, A. Okur, T. Weineisen, , H. Kübler, N. Navab, HP Wester, M. Schwaiger, M. Eiber Freehand SPECT for 111In-PSMA-I&T radioguided lymphadenectomy in prostate cancer patients Society of Nucler Medicine and Medical Imaging Annual Meeting, Baltimore, USA, 2015 (bib)
	B. Frisch, E. Storz, O. Zettinig, A. Shah, H. Kübler, N. Navab, HP Wester, M. Schwaiger, M. Eiber, T. Maurer PET/MRI/TRUS image fusion guided prostate biopsy: development of a research platform and initial clinical results Society of Nucler Medicine and Medical Imaging Annual Meeting, Baltimore, USA, 2015 (bib)
	J. Gardiazabal, J. Vogel, P. Matthies, M. Wieczorek, B. Frisch, N. Navab, S. I. Ziegler, T. Lasser Fully 3D thyroid imaging with mini gamma cameras Proceedings of Fully3D, Newport, USA, June 2015 (bib)
	T. Maurer, T. Weineisen, HP Wester, , A. Okur, G. Weirich, H. Kübler, M. Schwaiger, J. Gschwend, B. Frisch, M. Eiber PSMA-radioguided surgery: Introducing molecular surgery in patients with recurrent prostate cancer 2015 Annual Meeting of the American Urological Association, New Orleans, USA, 2015 (bib)
	T. Maurer, G. Weirich, , T. Weineisen, B. Frisch, A. Okur, N. Navab, M. Schwaiger, HP Wester, J. Gschwend, M. Eiber PSMA-radioguided surgery for metastatic lymph nodes in prostate cancer European Urology, in press, available online 6 May 2015 (bib)
	E. Storz, A. Shah, O. Zettinig, M. Eiber, H.-J. Wester, H. Kübler, J. Gschwend, M. Schwaiger, B. Frisch, T. Maurer PSMA-PET/MRI-guided fusion biopsy for the detection of prostate cancer Annual Congress of European Association of Urology (EAU), Madrid, March 2015 (bib)
	T. Maurer, T. Weineisen, HP Wester, , A. Okur, G. Weirich, H. Kübler, M. Schwaiger, J. Gschwend, B. Frisch, M. Eiber Introduction of PSMA-radioguided surgery in patients with recurrent prostate cancer: taking salvage lymphadenectomy to the next level? Annual Congress of European Association of Urology (EAU), Madrid, March 2015 (bib)
	T. Lasser, J. Gardiazabal, M. Wieczorek, P. Matthies, J. Vogel, B. Frisch, N. Navab Towards 3D thyroid imaging using robotic mini gamma cameras Bildverarbeitung für die Medizin, Lübeck, Germany, March 2015 (bib)
2014
	T. Maurer, G. Weirich, T. Weineisen, HP Wester, B. Frisch, A. Okur, H. Kübler, M. Schwaiger, J. Gschwend, M. Eiber Initial experience with PSMA-radioguided surgery in prostate cancer patients 3rd Meeting of the EAU Section of Urological Imaging, Lisbon, Portugal, 2014 (bib)
	M. Zvolsky, A. Cserkaszky, G. Cucciati, E. Garutti, P. Mitsakis, B. Frisch Monte-Carlo Simulation and Image Reconstruction for an Endoscopic TOFPET Detector IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
	B. Frisch, M. Eiber, J. Gardiazabal, P. Matthies, T. Maurer, A. Okur, T. Lasser, N. Navab Challenges for Intra-Operative SPECT IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
	A. Cserkaszky, M. Zvolsky, B. Frisch, T. Wendler Simulation Framework for Novel Medical Applications IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
	J. Gardiazabal, M. Esposito, P. Matthies, A. Okur, J. Vogel, S. Kraft, B. Frisch, T. Lasser, N. Navab Towards personalized interventional SPECT-CT imaging Proceedings of the 17th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Boston, USA, September 2014 (bib)
	A. Shah, O. Zettinig, T. Maurer, C. Precup, C. Schulte-zu-Berge, J. Weiss, B. Frisch, N. Navab An Open Source Multimodal Image-guided Prostate Biopsy Framework 3rd Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging (CLIP), 17th MICCAI, MIT, Boston, USA, September 2014. The original publication is available online at link.springer.com (bib)
2013
	N. Aubry, E. Auffray, F. B. Mimoun, N. Brillouet, R. Bugalho, , O. Charles, D. Cortinovis, P. Courday, A. Cserkaszky, C. Damon, K. Doroud, J.-M. Fischer, G. Fornaro, J.-M. Fourmigue, B. Frisch, B. Fuerst, J. Gardiazabal, K. Gadow, E. Garutti, C. Gaston, A. Gil-Ortiz, E. Guedj, T. Harion, P. Jarron, J. Kabadanian, T. Lasser, R. Laugier, P. Lecoq, D. Lombardo, S. Mandai, E. Mas, T. Meyer, O. Mundler, N. Navab, C. Ortigão, M. Paganoni, D. Perrodin, M. Pizzichemi, J. O. Prior, T. Reichl, M. Reinecke, M. Rolo, H.-C. Schultz-Coulon, M. Schwaiger, W. Shen, A. Silenzi, J. C. Silva, , I. Somlai-Schweiger, R. Stamen, J. Traub, J. Varela, V. Veckalns, V. Vidal, J. Vishwas, T. Wendler, C. Xu, S. I. Ziegler, M. Zvolsky EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography JINST 8 C04002. https://doi.org/10.1088/1748-0221/8/04/C04002 (bib)