BenjaminFrisch

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

Benjamin Frisch

Benjamin Frisch Dr. Benjamin Frisch
Senior Research Manager

Technische Universität München
Fakultät für Informatik
Chair for Computer Aided Medical Procedures & Augmented Reality
Boltzmannstr. 3
85748 Garching bei München
room: MI 03.13.058
phone: +49 89 289 19401
mail:

Laboratory Manager
Klinikum Rechts der Isar
Interdisziplinäres Forschungslabor
Ismaninger Str. 22
81675 München
room: 01.3 a-c
phone: +49 89 4140 6457

Research Interest

The development of modern medical procedures requires a strong link between health sciences, engineering research and industry. Translational research, the discipline that looks for practical applications of basic science, actively develops approaches that improve the quality of healthcare, keeping commercial opportunities in mind.

Being hosted by CAMP, with its renowned expertise in medical algorithmics and augmented reality, I enjoy having my laboratory at the TUM university hospital, Klinikum Rechts der Isar. The close contact with medical experts from many specialities allows for a better understanding of unmet clinical needs, while the accumulated knowledge of CAMP provides many options to define new or improve existing procedures. Being embedded in Bavaria's dynamic medical industry, I value good contacts with both established and start-up companies.

Although I focus my research on interventional imaging and medical robotics, I look forward to discuss ideas and define new projects on any topic at the crossroads of medicine and engineering.

Short Curriculum Vitae

  • 2013 - now : Staff Scientist at TUM
    • 2014 - now : Visiting researcher at Klinik für Nukklearmedizin, Klinikum Rechts der Isar, TUM (unpaid)
    • 2013 - now : External collaborator at CERN (unpaid)
  • 2010 - 2013: Senior Fellow at CERN
  • 2007 - 2010: Doctoral student at CERN (PhD obtained in 2012)
  • 2005 - 2006: Software quality manager at Siemens PSE, medical division
  • 2001 - 2007: studies in technical physics at TU Wien

Projects

with public funding

EndoTOFPET-US

EndoTOFPET-US

The project addresses and combines several objectives of the topics Health 2010.1.2-1, such as novel multimodality imaging tools, including a single-photon (quantum) counting PET detector head for the purpose of detecting and quantifying morphologic and functional markers and of developing new biomarkers of tumoural processes at the preclinical and clinical levels. Moreover the endoscopic approach, combined with an unprecedented PET timing resolution will allow more sensitive, more precise, lower radiation dose and less invasive imaging and intervention on small internal structures and lesions towards earlier detection and patient-tailored treatment of asymptomatic cancer types.
Advanced Robotics for Multi-Modal Interventional Imaging (RoBildOR)

Advanced Robotics for Multi-Modal Interventional Imaging (RoBildOR)

This project aims at developing advanced methods for robotic image acquisitions, enabling more flexible, patient- and process-specific functional and anatomical imaging with the operating theater. Using robotic manipulations, co-registered and dynamic imaging can be provided to the surgeon, allowing for optimal implementation of preoperative planning. In particular, this projects is the first one developing concepts for intraoperative SPECT-CT, and introduces intraoperative robotic Ultrasound imaging based on CT trajectory planning, enabling registration with angiographic data. With distinguished partners from Bavarian industry, this project has a fundamental contribution in developing safe, reliable, flexible, and multi-modal imaging technologies for the operating room of the future.
Inside-Out Tracking

Inside-Out Tracking

Current tracking solutions routinely used in a clinical, potentially surgically sterile, environment are limited to mechanical, electromagnetic or classic optical tracking. Main limitations of these technologies are respectively the size of the arm, the influence of ferromagnetic parts on the magnetic field and the line of sight between the cameras and tracking targets. These drawbacks limit the use of tracking in a clinical environment. The aim of this project is the development of so-called inside-out tracking, where one or more small cameras are fixed on clinical tools or robotic arms to provide tracking, both relative to other tools and static targets.
These developments are funded from the 1st of January 2016 to 31st of December 2017 by the ZIM project Inside-Out Tracking for Medical Applications (IOTMA).
Freehand SPECT for Sentinel Lymph Node Localization

Freehand SPECT for Sentinel Lymph Node Localization

Nuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging.

without public funding

Prostate Fusion Biopsy

Prostate Fusion Biopsy

Transrectal ultrasound (TRUS) guided biopsy remains the gold standard for diagnosis. However, it suffers from low sensitivity, leading to an elevated rate of false negative results. On the other hand, the recent advent of PET imaging using a novel dedicated radiotracer, Ga-labelled PSMA (Prostate Specific Membrane Antigen), combined with MR provides improved preinterventional identification of suspicious areas. Thus, MRI/TRUS fusion image-guided biopsy has evolved to be the method of choice to circumvent the limitations of TRUS-only biopsy. We propose a multimodal fusion image-guided biopsy framework that combines PET-MRI images with TRUS. Based on open-source software libraries, it is low cost, simple to use and has minimal overhead in clinical workflow. It is ideal as a research platform for the implementation and rapid bench to bedside translation of new image registration and visualization approaches.
In-PSMA Radioguided Surgery

In-PSMA Radioguided Surgery

With the advent of 68Ga-HBED-PSMA PET hybrid imaging techniques, even small and atypical localized metastatic lesions of prostate cancer can be visualized. However, these lesions might not be easy to localize intraoperatively. The aim of project is to evaluate intraoperative detection of metastatic lesions using a gamma probe and freehand SPECT after injection of radioactive-labelled PSMA-ligands in correlation with postoperative histological findings.
BioInnovation: From clinical needs to solution concepts

BioInnovation: From clinical needs to solution concepts

Learn how to successfully identify unmet clinical needs within the clinical routine and work towards possible and realistic solutions to solve those needs. Students will get to know tools helping them to be successful innovators in medical technology. This will include all steps from needs finding and selection to defining appropriate solution concepts, including the development of first prototypes. Get introduced to necessary steps for successful idea and concept creation and realize your project in an interdisciplinary teams comprising of physicists, informations scientists and business majors. During the project phase, you are supported by coaches from both industry and medicine, in order to allow for direct and continuous exchange.

Student Projects

We are permanently looking for motivated students for IDP, master thesis, bachelor thesis and HiWi? positions at IFL. Please contact me directly if you are interested in working on robotic imaging, nuclear medicine or any translation research with ongoing clinical applications!

Available:

Teaching

Responsible

Co-Responsible

Lecturer

Publications at CAMP

2017
O. Zettinig, J. Rackerseder, B. Lentes, T. Maurer, K. Westenfelder, M. Eiber, B. Frisch, N. Navab
Preconditioned Intensity-Based Prostate Registration using Statistical Deformation Models
IEEE International Symposium on Biomedical Imaging (ISBI), Melbourne, April 2017. (bib)
J. Rackerseder, A. Luque, C. Düwel, N. Navab, B. Frisch
Fully automated multi-modal anatomic atlas generation using 3D-Slicer
Workshops Bildverarbeitung fuer die Medizin (BVM), Heidelberg, March 12-14, 2017. (bib)
R. Göbl, S. Virga, J. Rackerseder, B. Frisch, N. Navab, C. Hennersperger
Acoustic window planning for ultrasound acquisition
International Journal of Computer Assisted Radiology and Surgery / 8th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Barcelona, Spain, June 2017.
The original publication is available online at link.springer.com
(bib)
O. Zettinig, B. Frisch, S. Virga, M. Esposito, A. Rienmüller, B. Meyer, C. Hennersperger, Y.-M. Ryang , N. Navab
3D Ultrasound Registration-based Visual Servoing for Neurosurgical Navigation
International Journal of Computer Assisted Radiology and Surgery, in press, 2017.
The original publication is available online at link.springer.com
(bib)
2016
B. Frisch, O. Zettinig, B. Fuerst, S. Virga, C. Hennersperger, N. Navab
Collaborative Robotic Ultrasound: Towards Clinical Application
Radiological Society of North America Annual Meeting, Chicago, USA, 2016 (bib)
B. Busam, M. Esposito, B. Frisch, N. Navab
Quaternionic Upsampling: Hyperspherical Techniques for 6 D-o-F Pose Tracking
International Conference on 3DVision (3DV), Stanford University, California, USA, October 2016 (bib)
C. Hennersperger, B. Fuerst, S. Virga, O. Zettinig, B. Frisch, T. Neff, N. Navab
Towards MRI-Based Autonomous Robotic US Acquisitions: A First Feasibility Study
IEEE Transactions on Medical Imaging, vol. 36, iss. 2, 2017
The original publication (open access) is available online at ieeexplore.ieee.org
(bib)
J. Gardiazabal, P. Matthies, J. Vogel, B. Frisch, N. Navab, S. I. Ziegler, T. Lasser
Flexible Mini Gamma Camera Reconstructions of Extended Sources using Step and Shoot and List Mode
Medical Physics 43(12):6418-6428, 2016. (bib)
S. Virga, O. Zettinig, M. Esposito, K. Pfister, B. Frisch, T. Neff, N. Navab, C. Hennersperger
Automatic Force-Compliant Robotic Ultrasound Screening of Abdominal Aortic Aneurysms
IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), Daejeon, South Korea, October 2016 (bib)
M. Esposito, B. Busam, C. Hennersperger, J. Rackerseder, N. Navab, B. Frisch
Multimodal US-Gamma Imaging using Collaborative Robotics for Cancer Staging Biopsies
International Journal of Computer Assisted Radiology and Surgery (bib)
R. Kojcev, B. Fuerst, O. Zettinig, J. Fotouhi, S.C. Lee, B. Frisch, R. Taylor, E. Sinibaldi, N. Navab
Dual-Robot Ultrasound-Guided Needle Placement: Closing the Planning-Imaging-Action Loop
International Journal of Computer Assisted Radiology and Surgery / International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Heidelberg, June 2016.
The original publication is available online at link.springer.com
(bib)
N. Navab, C. Hennersperger, B. Frisch, B. Fuerst
Personalized, Relevance-based Multimodal Robotic Imaging and Augmented Reality for Computer Assisted Interventions
Medical Image Analysis (bib)
O. Zettinig, B. Fuerst, R. Kojcev, M. Esposito, M. Salehi, W. Wein, J. Rackerseder, B. Frisch, N. Navab
Toward Real-time 3D Ultrasound Registration-based Visual Servoing for Interventional Navigation
IEEE International Conference on Robotics and Automation (ICRA), Stockholm, May 2016.
The original publication is available online at ieeexplore.ieee.org
(bib)
2015
B. Busam, M. Esposito, S. Che'Rose, N. Navab, B. Frisch
A Stereo Vision Approach for Cooperative Robotic Movement Therapy
International Conference on Computer Vision Workshop (ICCVW), Santiago, Chile, December 2015 (bib)
B. Fuerst, J. Sprung, F. Pinto, B. Frisch, T. Wendler, H. Simon, L. Mengus, N. S. van der Berg, H.G. van der Poel, F.W.B. van Leeuwen, N. Navab
First Robotic SPECT for Minimally Invasive Sentinel Lymph Node Mapping
IEEE Transactions on Medical Imaging, 2015. (bib)
P. Matthies, B. Frisch, J. Vogel, T. Lasser, M. Friebe, N. Navab
Inside-Out Tracking for Flexible Hand-held Nuclear Tomographic Imaging
IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
J. Gardiazabal, B. Frisch, P. Matthies, J. Vogel, S. I. Ziegler, N. Navab, T. Lasser
List-Mode Reconstruction for Continuous Freehand SPECT Acquisitions
IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
B. Frisch, et al.
First Results with an Interventional Handheld PET
IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, USA, November 2015 (bib)
F. Pinto, B. Fuerst, B. Frisch, N. Navab
Radiopositive Tissue Displacement Compensation for SPECT-guided Surgery
Proceedings of the 18th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Munich, Germany, October 2015 (bib)
M. Esposito, B. Busam, C. Hennersperger, J. Rackerseder, A. Lu, N. Navab, B. Frisch
Cooperative Robotic Gamma Imaging: Enhancing US-guided Needle Biopsy
Proceedings of the 18th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Munich, Germany, October 2015 (bib)
O. Zettinig, A. Shah, C. Hennersperger, M. Eiber, C. Kroll, H. Kübler, T. Maurer, F. Milletari, J. Rackerseder, C. Schulte zu Berge, E. Storz, B. Frisch, N. Navab
Multimodal Image-Guided Prostate Fusion Biopsy based on Automatic Deformable Registration
International Journal of Computer Assisted Radiology and Surgery / 6th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI), Barcelona, June 2015.
The original publication is available online at link.springer.com
(bib)
A. Shah, O. Zettinig, E. Storz, T. Maurer, M. Eiber, N. Navab, B. Frisch
Challenges in Multimodal Image-guided Targeted Prostate Biopsy
Hamlyn Symposium on Medical Robotics, London, UK, June 2015 (bib)
B. Frisch, T. Maurer, A. Okur, T. Weineisen, , H. Kübler, N. Navab, HP Wester, M. Schwaiger, M. Eiber
Freehand SPECT for 111In-PSMA-I&T radioguided lymphadenectomy in prostate cancer patients
Society of Nucler Medicine and Medical Imaging Annual Meeting, Baltimore, USA, 2015 (bib)
B. Frisch, E. Storz, O. Zettinig, A. Shah, H. Kübler, N. Navab, HP Wester, M. Schwaiger, M. Eiber, T. Maurer
PET/MRI/TRUS image fusion guided prostate biopsy: development of a research platform and initial clinical results
Society of Nucler Medicine and Medical Imaging Annual Meeting, Baltimore, USA, 2015 (bib)
J. Gardiazabal, J. Vogel, P. Matthies, M. Wieczorek, B. Frisch, N. Navab, S. I. Ziegler, T. Lasser
Fully 3D thyroid imaging with mini gamma cameras
Proceedings of Fully3D, Newport, USA, June 2015 (bib)
T. Maurer, T. Weineisen, HP Wester, , A. Okur, G. Weirich, H. Kübler, M. Schwaiger, J. Gschwend, B. Frisch, M. Eiber
PSMA-radioguided surgery: Introducing molecular surgery in patients with recurrent prostate cancer
2015 Annual Meeting of the American Urological Association, New Orleans, USA, 2015 (bib)
T. Maurer, G. Weirich, , T. Weineisen, B. Frisch, A. Okur, N. Navab, M. Schwaiger, HP Wester, J. Gschwend, M. Eiber
PSMA-radioguided surgery for metastatic lymph nodes in prostate cancer
European Urology, in press, available online 6 May 2015 (bib)
E. Storz, A. Shah, O. Zettinig, M. Eiber, H.-J. Wester, H. Kübler, J. Gschwend, M. Schwaiger, B. Frisch, T. Maurer
PSMA-PET/MRI-guided fusion biopsy for the detection of prostate cancer
Annual Congress of European Association of Urology (EAU), Madrid, March 2015 (bib)
T. Maurer, T. Weineisen, HP Wester, , A. Okur, G. Weirich, H. Kübler, M. Schwaiger, J. Gschwend, B. Frisch, M. Eiber
Introduction of PSMA-radioguided surgery in patients with recurrent prostate cancer: taking salvage lymphadenectomy to the next level?
Annual Congress of European Association of Urology (EAU), Madrid, March 2015 (bib)
T. Lasser, J. Gardiazabal, M. Wieczorek, P. Matthies, J. Vogel, B. Frisch, N. Navab
Towards 3D thyroid imaging using robotic mini gamma cameras
Bildverarbeitung für die Medizin, Lübeck, Germany, March 2015 (bib)
2014
T. Maurer, G. Weirich, T. Weineisen, HP Wester, B. Frisch, A. Okur, H. Kübler, M. Schwaiger, J. Gschwend, M. Eiber
Initial experience with PSMA-radioguided surgery in prostate cancer patients
3rd Meeting of the EAU Section of Urological Imaging, Lisbon, Portugal, 2014 (bib)
M. Zvolsky, A. Cserkaszky, G. Cucciati, E. Garutti, P. Mitsakis, B. Frisch
Monte-Carlo Simulation and Image Reconstruction for an Endoscopic TOFPET Detector
IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
B. Frisch, M. Eiber, J. Gardiazabal, P. Matthies, T. Maurer, A. Okur, T. Lasser, N. Navab
Challenges for Intra-Operative SPECT
IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
A. Cserkaszky, M. Zvolsky, B. Frisch, T. Wendler
Simulation Framework for Novel Medical Applications
IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA, November 2014 (bib)
J. Gardiazabal, M. Esposito, P. Matthies, A. Okur, J. Vogel, S. Kraft, B. Frisch, T. Lasser, N. Navab
Towards personalized interventional SPECT-CT imaging
Proceedings of the 17th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Boston, USA, September 2014 (bib)
A. Shah, O. Zettinig, T. Maurer, C. Precup, C. Schulte zu Berge, J. Weiss, B. Frisch, N. Navab
An Open Source Multimodal Image-guided Prostate Biopsy Framework
3rd Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging (CLIP), 17th MICCAI, MIT, Boston, USA, September 2014.
The original publication is available online at link.springer.com
(bib)


UsersForm
Title: Dr.
Circumference of your head (in cm):  
Firstname: Benjamin
Middlename:  
Lastname: Frisch
Picture: profil1.jpg
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Nationality: Austria
Languages: English, German, French, Spanish, Portuguese
Groups: Medical Imaging, Molecular Imaging, Computer-Aided Surgery, IFL, Ultrasound
Expertise: Surgical Workflow, Registration/Visualization, Segmentation, Medical Imaging, Molecular Imaging, Computer-Aided Surgery
Position: Scientific Staff
Status: Active
Emailbefore: benjamin.frisch
Emailafter: tum.de
Room: MI 03.13.058
Telephone: +49 89 289 19401
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